AiPD: Autoinhibited Protein Database

Gene name	Nccrp1 (Fbxo50)
Protein name	F-box only protein 50
Names	NCC receptor protein 1, NCCRP-1, Non-specific cytotoxic cell receptor protein 1 homolog
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:233038
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-78 (Predicted disordered autoinhibitory region) PR

1-78 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-G3X9C2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs248488400	9	T>A	No	EVA
rs3388873830	22	S>L	No	EVA
rs3388885634	30	Q>H	No	EVA
rs3388887638	37	S>Y	No	EVA
rs3388893022	78	P>L	No	EVA
rs3388867424	79	P>Q	No	EVA
rs246634168	113	P>H	No	EVA
rs246634168	113	P>R	No	EVA
rs3388867483	115	G>D	No	EVA
rs3388885678	191	L>M	No	EVA
rs3388890450	193	A>T	No	EVA
rs3388898918	196	R>H	No	EVA
rs3413155304	198	T>M	No	EVA
rs3388867434	222	S>P	No	EVA
rs222446508	236	Y>H	No	EVA
rs3388885636	238	Q>E	No	EVA
rs3388885686	249	G>E	No	EVA
rs3388896358	249	G>V	No	EVA
rs3388896760	250	L>V	No	EVA
rs3388873890	251	R>W	No	EVA
rs3388867479	253	T>A	No	EVA

Type	Name	Position	InterPro Accession
domain	F-box associated (FBA) domain	83 - 264	IPR007397

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
SCF ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

Name	Definition
No GO annotations for molecular function

Name	Definition
glycoprotein catabolic process	The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	Homo sapiens (Human)	PR
Q6DIA9	Fbxo27	F-box only protein 27	Mus musculus (Mouse)	PR
Q80UW2	Fbxo2	F-box only protein 2	Mus musculus (Mouse)	PR