F4JLZ6
Gene name |
SMO1-3 |
Protein name |
Methylsterol monooxygenase 1-3 |
Names |
Sterol 4-alpha-methyl-oxidase 1-3, AtSMO1-3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G22755 |
EC number |
1.14.18.9: With another compound as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4JLZ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4JLZ6-F1 | Predicted | AlphaFoldDB |
19 variants for F4JLZ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06754876 | 19 | T>S | No | 1000Genomes | |
| tmp_4_11953547_G_C | 21 | F>L | No | 1000Genomes | |
| tmp_4_11953501_C_T | 37 | V>I | No | 1000Genomes | |
| ENSVATH00531692 | 62 | T>S | No | 1000Genomes | |
| tmp_4_11953414_C_T | 66 | D>N | No | 1000Genomes | |
| tmp_4_11953381_A_G | 77 | S>P | No | 1000Genomes | |
| tmp_4_11953302_G_A | 103 | S>F | No | 1000Genomes | |
| tmp_4_11953001_T_G | 109 | M>L | No | 1000Genomes | |
| ENSVATH06754868 | 138 | T>A | No | 1000Genomes | |
| ENSVATH12154647 | 176 | A>G | No | 1000Genomes | |
| tmp_4_11952788_T_C | 180 | I>V | No | 1000Genomes | |
| ENSVATH02910532 | 197 | M>I | No | 1000Genomes | |
| ENSVATH00531690 | 208 | F>I | No | 1000Genomes | |
| ENSVATH06754863 | 233 | P>A | No | 1000Genomes | |
| ENSVATH12154645 | 248 | S>T | No | 1000Genomes | |
| ENSVATH06754855 | 276 | H>Q | No | 1000Genomes | |
| ENSVATH12154613 | 282 | A>T | No | 1000Genomes | |
| ENSVATH06754854 | 286 | R>G | No | 1000Genomes | |
| ENSVATH06754853 | 290 | H>Q | No | 1000Genomes |
No associated diseases with F4JLZ6
1 regional properties for F4JLZ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Fatty acid hydroxylase | 128 - 263 | IPR006694 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.18.9 | With another compound as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| C-4 methylsterol oxidase activity | Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(II)- + 5 H+ + 3 O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(III)- |
| iron ion binding | Binding to an iron (Fe) ion. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZLL6 | MSMO1 | Methylsterol monooxygenase 1 | Gallus gallus (Chicken) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIPYPTVEDA | SVALGRNLTW | FETVWFDYSA | TKSNFHVYCH | TILVLFLVFS | LAPFPLVIVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WTGWFDQFKI | QKKVKYSLSD | MFQCYKEVMK | LFLLVVGTLQ | IVSYPSIQMV | GIRSGLPLPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LMEIVAQLVV | YFLIEDYTNY | WIHRWMHCKW | GYEKIHRIHH | EYTSPIGYAS | PYAHWAEILI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGIPTFLGPA | IAPGHIMTFW | LWISLRQFEA | IETHSGYDFP | WSVTKLIPFY | GGPEYHDYHH |
| 250 | 260 | 270 | 280 | 290 | |
| YVGGQSQSNF | ASVFTYCDYI | YGTDKGYRIH | KKLLHHQIKE | EAEEKRVRKH | D |