F4ISV6
Gene name |
THG2 (At2g32320, T32F6.16) |
Protein name |
tRNA(His) guanylyltransferase 2 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G32320 |
EC number |
2.7.7.79: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4ISV6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4ISV6-F1 | Predicted | AlphaFoldDB |
40 variants for F4ISV6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05643282 | 14 | V>A | No | 1000Genomes | |
| ENSVATH01938622 | 23 | L>M | No | 1000Genomes | |
| ENSVATH05643284 | 29 | D>Y | No | 1000Genomes | |
| ENSVATH00256817 | 31 | R>C | No | 1000Genomes | |
| tmp_2_13728033_T_G | 32 | D>E | No | 1000Genomes | |
| tmp_2_13728298_A_G | 64 | E>G | No | 1000Genomes | |
| tmp_2_13728312_G_A | 69 | V>I | No | 1000Genomes | |
| tmp_2_13728335_C_G | 76 | D>E | No | 1000Genomes | |
| ENSVATH14578085 | 77 | E>K | No | 1000Genomes | |
| ENSVATH01938625 | 85 | A>S | No | 1000Genomes | |
| ENSVATH01938625 | 85 | A>T | No | 1000Genomes | |
| ENSVATH01938627 | 97 | L>M | No | 1000Genomes | |
| ENSVATH05643291 | 107 | V>I | No | 1000Genomes | |
| ENSVATH14578086 | 118 | H>R | No | 1000Genomes | |
| ENSVATH00256819 | 145 | A>T | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_2_13728946_T_A | 171 | L>* | No | 1000Genomes | |
| ENSVATH14578087 | 174 | T>A | No | 1000Genomes | |
| tmp_2_13728971_G_T | 179 | K>N | No | 1000Genomes | |
| ENSVATH05643295 | 203 | V>E | No | 1000Genomes | |
| tmp_2_13729201_A_T | 214 | T>S | No | 1000Genomes | |
| ENSVATH13505464 | 215 | K>E | No | 1000Genomes | |
| ENSVATH01938634 | 223 | F>C | No | 1000Genomes | |
| ENSVATH13505475 | 224 | F>L | No | 1000Genomes | |
| ENSVATH01938638 | 228 | L>V | No | 1000Genomes | |
| tmp_2_13729602_G_T | 239 | K>N | No | 1000Genomes | |
| tmp_2_13729613_G_A | 243 | R>Q | No | 1000Genomes | |
| tmp_2_13730236_A_G | 332 | M>V | No | 1000Genomes | |
| ENSVATH13505495 | 391 | G>R | No | 1000Genomes | |
| tmp_2_13730610_T_G | 392 | D>E | No | 1000Genomes | |
| tmp_2_13730644_T_A | 404 | S>T | No | 1000Genomes | |
| ENSVATH07907480 | 424 | W>C | No | 1000Genomes | |
| ENSVATH14578093 | 463 | E>Q | No | 1000Genomes | |
| ENSVATH13505503 | 466 | E>K | No | 1000Genomes | |
| tmp_2_13731035_G_A | 469 | S>N | No | 1000Genomes | |
| tmp_2_13731037_C_T | 470 | Q>* | No | 1000Genomes | |
| ENSVATH00256830 | 481 | V>A | No | 1000Genomes | |
| ENSVATH00256831 | 515 | G>V | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_2_13731366_T_A | 518 | Y>N | No | 1000Genomes | |
| ENSVATH01938660 | 529 | Q>K | No | 1000Genomes | |
| ENSVATH01938661 | 536 | F>S | No | 1000Genomes |
No associated diseases with F4ISV6
No regional properties for F4ISV6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for F4ISV6 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.79 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| tRNA guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
| tRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F4IRQ5 | THG1 | tRNA(His) guanylyltransferase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANSKYEYVK | SFEVEDEVMF | PNLIIIRIDG | RDFSRFSQVH | KFEKPNDETS | LNLMNSCASS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLVEYPDIVF | AYGYSDEYSF | VFKKASRFYQ | RRASKILSLV | ASFFAAVYVT | KWKEFFPHTK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEYAPSFASK | VVSCASVEVL | QAYLAWRQHD | CHISNQYDTC | LWMLVKSGKT | LSETQEILKD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TQKQQRNELL | FQQFGINYKM | LPVLFRQGSC | LFKTKVIFSI | ISFFYFLLEE | TVKHDENGKP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKRLRRRETL | VHSENVAGRS | FWNEHSSLHK | DLGHFAKDIG | KIEPDYVKSF | QFESRLLPLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WVVVRIDGCH | FHRFSEVHEF | EKPNDEQALK | LMNSCAVAVL | EEFQDIAFAY | GVSDEFSFVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KNKSELYKRQ | SSKIISAVVS | FFTSTYMMRW | GDFFPHKKLK | YPPSFDGRAV | CYPTSDILLD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLAWRQVDCH | INNQYNTCFW | MLVKSGKSKI | QAQDYLKGTQ | TREKNELLSQ | QFGIEYNSLP |
| 490 | 500 | 510 | 520 | 530 | |
| VIFRMGSSVF | RLKTQEGVTE | ENGEVSGKQV | EAEVGVDYSN | IIDQCFWQQH | PHILSFS |