F4IRQ5
Gene name |
THG1 (At2g31580, T9H9.10) |
Protein name |
tRNA(His) guanylyltransferase 1 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G31580 |
EC number |
2.7.7.79: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4IRQ5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4IRQ5-F1 | Predicted | AlphaFoldDB |
35 variants for F4IRQ5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14575812 | 5 | V>L | No | 1000Genomes | |
| tmp_2_13444837_A_T | 20 | V>D | No | 1000Genomes | |
| ENSVATH05639107 | 21 | F>S | No | 1000Genomes | |
| ENSVATH00255933 | 32 | V>I | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_2_13444757_C_T | 47 | D>N | No | 1000Genomes | |
| tmp_2_13444663_C_T | 78 | R>H | No | 1000Genomes | |
| ENSVATH05639104 | 79 | D>E | No | 1000Genomes | |
| ENSVATH05639103 | 81 | S>P | No | 1000Genomes | |
| ENSVATH14575809 | 111 | E>G | No | 1000Genomes | |
| tmp_2_13444014_C_G | 142 | K>N | No | 1000Genomes | |
| ENSVATH05639096 | 146 | L>F | No | 1000Genomes | |
| tmp_2_13443994_G_T | 149 | S>Y | No | 1000Genomes | |
| tmp_2_13443961_T_C | 160 | K>R | No | 1000Genomes | |
| ENSVATH05639095 | 162 | F>S | No | 1000Genomes | |
| ENSVATH13496857 | 171 | A>V | No | 1000Genomes | |
| ENSVATH13496856 | 184 | A>T | No | 1000Genomes | |
| ENSVATH01934583 | 195 | Q>E | No | 1000Genomes | |
| tmp_2_13443693_G_A | 206 | T>I | No | 1000Genomes | |
| ENSVATH05639089 | 227 | D>A | No | 1000Genomes | |
| tmp_2_13443411_T_C | 239 | Q>R | No | 1000Genomes | |
| tmp_2_13442902_C_T | 286 | V>I | No | 1000Genomes | |
| ENSVATH01934578 | 289 | E>A | No | 1000Genomes | |
|
tmp_2_13442873_G_C ENSVATH05639084 |
295 | S>R | No | 1000Genomes | |
| tmp_2_13442848_A_C | 304 | Y>D | No | 1000Genomes | |
| ENSVATH13496840 | 319 | P>A | No | 1000Genomes | |
| ENSVATH14575803 | 331 | L>S | No | 1000Genomes | |
| tmp_2_13442723_G_T | 345 | H>Q | No | 1000Genomes | |
| ENSVATH05639080 | 403 | K>R | No | 1000Genomes | |
| ENSVATH01934573 | 483 | N>T | No | 1000Genomes | |
| tmp_2_13441658_C_T | 493 | G>D | No | 1000Genomes | |
| ENSVATH00255930 | 505 | R>H | No | 1000Genomes | |
| ENSVATH13496822 | 514 | L>F | No | 1000Genomes | |
| ENSVATH01934572 | 538 | K>E | No | 1000Genomes | |
| ENSVATH00255928 | 540 | L>V | No | 1000Genomes | |
| ENSVATH05639072 | 568 | S>S | No | 1000Genomes |
No associated diseases with F4IRQ5
4 regional properties for F4IRQ5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | tRNAHis guanylyltransferase catalytic domain | 53 - 180 | IPR024956-1 |
| domain | tRNAHis guanylyltransferase catalytic domain | 322 - 448 | IPR024956-2 |
| domain | Thg1 C-terminal domain | 186 - 273 | IPR025845-1 |
| domain | Thg1 C-terminal domain | 453 - 532 | IPR025845-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.79 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| tRNA guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| positive regulation of cell cycle | Any process that activates or increases the rate or extent of progression through the cell cycle. |
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
| tRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F4ISV6 | THG2 | tRNA(His) guanylyltransferase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MINSVGVVRK | EAENCNCLQV | FFVSGSFKVD | SVEAKKKEEN | FRETLRDMAN | SKYEYVKSFE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEDEVMLPNL | MVVRIDGRDF | SRFSQVHEFE | KPNDETALNL | MNSCSAAVLE | EFPDIIFAYG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YSDEYSFVFK | KTSRFYQRRA | SKILSLVASF | FAAVYVTKWK | EFFPQRKLLY | APSFSSKVVS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CASAEVLQAY | LAWRQQDCHA | NNQYDTCFWM | LVKSGKSVSE | TQEILKDTQK | QQKNELLFQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGINYKTLPE | LFRQGSCLFK | KKVEETVKHD | ENGNPVKRLR | RKAVFVHSEN | IAGRSFWNEQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSLYNDLGHF | TKDIGKIEPD | FIRSFQFENK | LLPLTWVVVR | IDGCHFHRFS | DVHEFEKPND |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EQALKLMNSC | AVAVLEEFED | IHFAYGVSDE | YSFVLKKESE | LYKRQSSKII | SAVASFFTST |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YVLQWGEFFP | HKELKYPPSF | DGRAVCYPTY | NILLDYLAWR | QVDCHINNQY | NTCFWMLVKS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GKNKTQSQDY | LKGTQTREKN | ELLSRQFGIE | YNSLPVIFRM | GSSVFRLKEA | ENGVVSGKKL |
| 550 | 560 | ||||
| EGEVVVDHCN | IIERCFWEEH | LHILSYS |