AiPD: Autoinhibited Protein Database

Gene name	KMS2
Protein name	Vacuole membrane protein KMS2
Names	Protein KILLING ME SLOWLY 2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G05360
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-53 (Predicted disordered autoinhibitory region) PR

1-53 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-F4I8Q7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH04523732	37	T>I	No	1000Genomes
ENSVATH10635543	49	V>A	No	1000Genomes
ENSVATH04523747	94	Y>C	No	1000Genomes
tmp_1_1565670_T_C	103	F>L	No	1000Genomes
tmp_1_1565847_T_G	123	L>V	No	1000Genomes
ENSVATH00007006	134	V>A	No	1000Genomes
tmp_1_1565906_A_T	142	L>F	No	1000Genomes
ENSVATH01015179	146	I>V	No	1000Genomes
ENSVATH13854551	153	K>N	No	1000Genomes
ENSVATH04523752	164	H>L	No	1000Genomes
ENSVATH00007007	167	G>C	No	1000Genomes
tmp_1_1566004_T_G	175	V>G	No	1000Genomes
tmp_1_1566003_G_A	175	V>I	No	1000Genomes
tmp_1_1566073_G_A	198	G>E	No	1000Genomes
ENSVATH01015188	211	L>F	No	1000Genomes
tmp_1_1566356_G_T	214	G>C	No	1000Genomes
ENSVATH04523764	227	N>K	No	1000Genomes
ENSVATH00007013	232	K>I	No	1000Genomes
tmp_1_1566622_C_T	262	P>L	No	1000Genomes
tmp_1_1566830_T_C	299	V>A	No	1000Genomes
tmp_1_1566911_G_A	326	G>D	No	1000Genomes
tmp_1_1566916_G_T	328	A>S	No	1000Genomes
tmp_1_1566929_C_T	332	P>L	No	1000Genomes
ENSVATH04523773	347	I>V	No	1000Genomes
ENSVATH10635702	358	V>I	No	1000Genomes
tmp_1_1567110_G_C	361	W>C	No	1000Genomes
tmp_1_1567171_G_A	382	G>S	No	1000Genomes
tmp_1_1567219_G_C	398	E>Q	No	1000Genomes
ENSVATH04523779	405	T>A	No	1000Genomes
ENSVATH00007022	408	S>P	No	1000Genomes
ENSVATH00007023	411	T>S	No	1000Genomes
ENSVATH13854553	413	K>*	No	1000Genomes
ENSVATH13854554	416	K>R	No	1000Genomes
ENSVATH13854554	416	K>T	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	BTB/POZ domain	23 - 128	IPR000210
repeat	Kelch repeat type 1	328 - 426	IPR006652-1
repeat	Kelch repeat type 1	427 - 592	IPR006652-2
domain	BTB/Kelch-associated	133 - 237	IPR011705
domain	Kelch-like protein 15, BTB/POZ domain	1 - 137	IPR030597
domain	Kelch-like protein 15, BACK domain	128 - 235	IPR047030

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endomembrane system	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
No GO annotations for molecular function

Name	Definition
endomembrane system organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9XWU8	epg-3	Ectopic P granules protein 3	Caenorhabditis elegans	PR