AiPD: Autoinhibited Protein Database

E9PJI5

Gene name	NPIPA7
Protein name	Nuclear pore complex-interacting protein family member A7
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:101059953
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-202 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

48-202 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for E9PJI5

Entry ID	Method	Resolution	Chain	Position	Source
AF-E9PJI5-F1	Predicted				AlphaFoldDB

113 variants for E9PJI5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1291516097 CA395206327	65	V>E		No	ClinGen TOPMed gnomAD
CA395206330 rs1291516097	65	V>G		No	ClinGen TOPMed gnomAD
rs1231340525 CA395206319	65	V>L		No	ClinGen gnomAD
CA395206388 rs1222387542	70	T>A		No	TOPMed gnomAD ClinGen
CA395206392 rs1443664435	70	T>N		No	gnomAD ClinGen
CA395206386 rs1222387542	70	T>P		No	TOPMed gnomAD ClinGen
CA395206390 rs1222387542	70	T>S		No	TOPMed gnomAD ClinGen
CA279018450 rs914936711	71	I>T		No	ClinGen TOPMed gnomAD
rs1567585094 CA395206401	71	I>V		No	Ensembl ClinGen
CA395206428 rs946363297	72	F>L		No	ClinGen TOPMed gnomAD
rs760727162 CA395206435	73	P>L		No	ClinGen ExAC TOPMed gnomAD
rs760727162 CA7927438	73	P>R		No	ClinGen ExAC TOPMed gnomAD
rs775486134 CA7927437	73	P>S		No	ExAC gnomAD ClinGen
rs1417754134 CA395206440	74	S>P		No	gnomAD ClinGen
TCGA novel	75	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA279018453 rs1042362823	75	Q>E		No	TOPMed ClinGen
rs750329494 CA7927440	75	Q>R		No	ClinGen ExAC gnomAD
rs762783215 CA7927441	82	T>M		No	ExAC TOPMed gnomAD ClinGen
CA395206596 rs1321307266	83	D>V		No	TOPMed ClinGen
rs1388109168 CA395206580	83	D>Y		No	ClinGen TOPMed
rs1308444067 CA395206606	84	V>I		No	gnomAD ClinGen
CA395206639 rs1390806957	85	Q>R		No	TOPMed ClinGen
CA395206664 rs1472382284	86	Q>H		No	ClinGen TOPMed
CA279018455 rs944571256	86	Q>K		No	ClinGen TOPMed
rs1040244767 CA395206698	88	A>S		No	ClinGen TOPMed gnomAD
rs1040244767 CA279018456	88	A>T		No	ClinGen TOPMed gnomAD
CA7927442 rs766147844	89	R>W		No	ExAC gnomAD ClinGen
rs1379805237 CA395206744	91	S>F		No	ClinGen TOPMed gnomAD
rs900309422 CA279018457	92	N>H		No	TOPMed ClinGen
CA395206764 rs1314916153	92	N>K		No	gnomAD ClinGen
rs1229007602 CA395206756	92	N>T		No	gnomAD ClinGen
rs879335983 CA279018458	93	R>C		No	ClinGen TOPMed gnomAD
CA395206776 rs1227860108	93	R>H		No	TOPMed gnomAD ClinGen
rs751202960 CA395206797	94	R>C		No	ClinGen ExAC TOPMed gnomAD
CA395206803 rs1484272157	94	R>H		No	ClinGen TOPMed gnomAD
CA7927443 rs751202960	94	R>S		No	ClinGen ExAC TOPMed gnomAD
CA7927444 rs754594654	97	E>K		No	ExAC gnomAD ClinGen
CA395206874 rs1257478293	98	G>*		No	ClinGen TOPMed gnomAD
CA395206870 CA395206872 rs1257478293	98	G>R		No	TOPMed gnomAD ClinGen
CA395206928 rs1485293563	99	I>N		No	gnomAD ClinGen
CA395206921 rs1482966264	99	I>V		No	ClinGen TOPMed
rs1188636024 CA395206999	102	V>A		No	TOPMed gnomAD ClinGen
rs1188636024 CA395207002	102	V>G		No	TOPMed gnomAD ClinGen
CA395207015 rs1180124842	103	L>R		No	gnomAD ClinGen
CA395207025 rs1249553966	104	E>K		No	ClinGen gnomAD
rs1278118792 CA395207057	105	D>E		No	ClinGen TOPMed
rs990614378 CA279018468	109	L>S		No	ClinGen TOPMed gnomAD
CA395207159 rs1172810449	110	W>*		No	TOPMed gnomAD ClinGen
CA395207223 rs1425563642	112	Q>H		No	ClinGen TOPMed gnomAD
CA395207299 rs1226488483	115	T>N		No	TOPMed ClinGen
CA395207351 rs1156902585	118	R>*		No	TOPMed gnomAD ClinGen
CA279018469 rs914967567	118	R>Q		No	ClinGen TOPMed gnomAD
rs755684730 CA7927448	122	R>C		No	ClinGen ExAC gnomAD
rs1434511277 CA395207418	122	R>H		No	TOPMed gnomAD ClinGen
CA395207446 rs1367648491	124	M>R		No	ClinGen gnomAD
TCGA novel	126	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395207482 rs1274637315	127	T>K		No	TOPMed gnomAD ClinGen
CA395207484 rs1274637315	127	T>R		No	ClinGen TOPMed gnomAD
CA395207492 rs1368677173	128	T>I		No	ClinGen gnomAD
CA395207507 rs1282852334	130	V>I		No	ClinGen gnomAD
CA395207535 rs1208865217	132	R>C		No	ClinGen TOPMed gnomAD
CA395207536 rs1269431194	132	R>H		No	ClinGen TOPMed gnomAD
rs1197646025 CA395207546	133	H>P		No	ClinGen TOPMed gnomAD
CA395207541 rs1466886059	133	H>Y		No	ClinGen gnomAD
CA395207571 rs1246910126	135	K>E		No	gnomAD ClinGen
CA395207583 rs1478924149	136	I>V		No	gnomAD ClinGen
CA395207605 rs1175230910	137	N>K		No	ClinGen TOPMed gnomAD
CA395207616 rs1237157075	138	G>V		No	TOPMed ClinGen
CA395207627 rs1211085429	139	K>N		No	TOPMed ClinGen
CA395207639 rs1555530905	140	R>K		No	ClinGen Ensembl
CA395207640 rs1407228033	140	R>S		No	TOPMed gnomAD ClinGen
CA279018470 rs541173073	142	T>S		No	1000Genomes ClinGen
CA279018472 rs527482398	143	A>D		No	1000Genomes ClinGen
CA395207665 rs1457656420	143	A>T		No	ClinGen TOPMed gnomAD
rs1160040227 CA395207679	144	K>R		No	gnomAD ClinGen
CA395207687 rs1390840548	145	E>K		No	gnomAD ClinGen
CA395207768 rs1470543063	148	R>K		No	TOPMed ClinGen
rs771224856 CA7927451	150	L>P		No	ExAC TOPMed gnomAD ClinGen
CA279018514 rs1021760374	151	S>R		No	TOPMed gnomAD ClinGen
CA395207791 rs1596865731	151	S>R		No	Ensembl ClinGen
CA279018516 rs977813004	152	M>V		No	TOPMed gnomAD ClinGen
CA395207824 rs1472879777	155	R>C		No	ClinGen TOPMed gnomAD
CA395207823 rs1472879777	155	R>G		No	ClinGen TOPMed gnomAD
CA395207825 rs1184182862	155	R>H		No	TOPMed gnomAD ClinGen
rs1184182862 CA395207827	155	R>L		No	ClinGen TOPMed gnomAD
rs1193713551 CA395207845	158	R>*		No	TOPMed gnomAD ClinGen
rs1193713551 CA395207844	158	R>G		No	ClinGen TOPMed gnomAD
CA395207846 rs1596865840	158	R>I		No	Ensembl ClinGen
rs923625109 CA279018517	158	R>S		No	ClinGen TOPMed gnomAD
rs1480608619 CA395207858	160	E>K		No	TOPMed gnomAD ClinGen
CA395207872 rs1596865890	161	E>D		No	ClinGen Ensembl
rs1407247355 CA395207888	163	Q>H		No	gnomAD ClinGen
rs1454010458 CA395207902	164	V>A		No	ClinGen TOPMed
rs1327310557 CA395207893	164	V>M		No	ClinGen gnomAD
CA279018519 rs976057069	165	S>P		No	ClinGen TOPMed gnomAD
CA395207915 rs1400456650	166	E>Q		No	ClinGen TOPMed
CA395207950 rs1427053158	168	E>G		No	gnomAD ClinGen
TCGA novel	169	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395207955 rs1409070625	169	E>K		No	ClinGen TOPMed
CA395208021 rs1310455655	174	D>N		No	ClinGen gnomAD
TCGA novel	175	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395208049 rs1354076302	176	K>E		No	TOPMed gnomAD ClinGen
rs1284224101 CA395208067	177	E>V		No	ClinGen gnomAD
rs1358062788 CA395208085	179	H>Y		No	ClinGen TOPMed gnomAD
rs1176803016 CA395208118	182	M>L		No	ClinGen Ensembl
rs1367850338 CA395208210	189	Q>R		No	TOPMed gnomAD ClinGen
CA395209127 rs1555531164	268	E>K		No	Ensembl ClinGen
rs1555531167 CA395209157	270	V>L		No	ClinGen Ensembl
CA395209447 rs1555531168	301	A>V		No	Ensembl ClinGen
CA395210018 rs1596867008	340	P>L		No	Ensembl ClinGen
CA395210050 rs1555531170	343	A>V		No	Ensembl ClinGen
CA395210136 rs1596867023	351	P>A		No	ClinGen Ensembl
rs1596867058 CA395210204	357	L>I		No	Ensembl ClinGen

No associated diseases with E9PJI5

No regional properties for E9PJI5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for E9PJI5

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
E9PKD4	NPIPA5	Nuclear pore complex-interacting protein family member A5	Homo sapiens (Human)	PR
F8WFD2	NPIPA3	Nuclear pore complex-interacting protein family member A3	Homo sapiens (Human)	PR
P0DM63	NPIPA8	Nuclear pore complex-interacting protein family member A8	Homo sapiens (Human)	PR
Q9UND3	NPIPA1	Nuclear pore complex-interacting protein family member A1	Homo sapiens (Human)	PR
E9PIF3	NPIPA2	Nuclear pore complex-interacting protein family member A2	Homo sapiens (Human)	PR
A6NJ64	NPIPB2	Putative nuclear pore complex-interacting protein family member B2	Homo sapiens (Human)	PR

10	20	30	40	50	60
MFCCLGYEWL	SGGCTTWHSA	WVINTLADHR	HRGTDFGGSP	WLLIITVFLR	SYKFAISLCT
70	80	90	100	110	120
SYLCVSFLKT	IFPSQNGHDG	STDVQQRARR	SNRRRQEGIK	IVLEDIFTLW	RQVETKVRAK
130	140	150	160	170	180
IRKMKVTTKV	NRHDKINGKR	KTAKEHLRKL	SMKEREHREE	ERQVSEAEEN	GKLDMKEIHT
190	200	210	220	230	240
YMEMFQRAQA	LRRRAEDYYR	CKITPSARKP	LCNRVRMAAV	EHRHSSGLPY	WPYLTAETLK
250	260	270	280	290	300
NRMGHQPPPP	TQQHSIIDNS	LSLKTPSECV	LYPLPPSADD	NLKTPPECLL	TPLPPSALPS
310	320	330	340	350	360
ADDNLKTPAE	CLLYPLPPSA	DDNLKTPPEC	LLTPLPPSAP	PSADDNLKTP	PECVCSLPFH

PQRMIISRN