Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for E9PIF3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-E9PIF3-F1 | Predicted | AlphaFoldDB |
138 variants for E9PIF3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1555520330 CA395192148 |
97 | H>L | No |
ClinGen Ensembl |
|
|
CA395192249 rs1383405963 |
112 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1399845137 CA395192251 |
112 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA395192256 rs1299183562 |
113 | R>C | No |
ClinGen gnomAD |
|
|
CA395192257 rs1342616213 |
113 | R>H | No |
ClinGen gnomAD |
|
|
CA395192463 rs1257748789 |
141 | C>R | No |
ClinGen gnomAD |
|
|
rs1351420203 CA395192615 |
162 | A>T | No |
ClinGen gnomAD |
|
|
CA395192620 rs1555520343 |
162 | A>V | No |
ClinGen Ensembl |
|
|
rs1555520401 CA395193488 |
175 | E>K | No |
ClinGen Ensembl |
|
|
CA395193932 rs1406190399 |
206 | R>H | No |
ClinGen TOPMed |
|
|
CA395193945 rs1157658549 |
207 | A>V | No |
ClinGen TOPMed |
|
|
CA395193953 rs1321312153 |
208 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1489081146 CA395193967 |
209 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1388178303 CA395193993 |
212 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1419560689 CA395195607 |
235 | R>S | No |
ClinGen gnomAD |
|
|
CA395195638 rs1159640592 |
237 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA278963691 rs201587671 |
239 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA278963693 rs1020033204 |
242 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA395195724 rs1388665462 |
242 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA395195731 rs1256444139 |
243 | H>Y | No |
ClinGen gnomAD |
|
|
CA395195813 rs1179065509 |
246 | G>V | No |
ClinGen TOPMed |
|
|
CA395195867 rs1374592097 |
248 | P>L | No |
ClinGen gnomAD |
|
|
CA395195882 rs1239280943 |
249 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
CA395195925 rs1204874369 |
250 | W>C | No |
ClinGen TOPMed |
|
|
CA278963694 rs966832854 |
254 | T>R | No |
ClinGen TOPMed gnomAD |
|
|
CA395196149 rs978696950 |
258 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1219079061 CA395196160 |
259 | K>E | No |
ClinGen gnomAD |
|
|
CA395196231 rs1159964017 |
261 | R>K | No |
ClinGen gnomAD |
|
|
CA395196268 rs1411392867 |
262 | M>I | No |
ClinGen gnomAD |
|
|
CA395196308 rs1336027513 |
264 | H>R | No |
ClinGen TOPMed |
|
|
rs1192433659 CA395196323 |
265 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1247731449 CA395196363 |
267 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA395196350 rs1455732340 |
267 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA395196403 rs1336740445 |
271 | Q>E | No |
ClinGen TOPMed |
|
|
CA395196456 rs1382679828 |
273 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs201304654 CA278963696 |
276 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1242288778 CA395196576 |
279 | S>F | No |
ClinGen TOPMed |
|
|
CA395196585 rs1365282816 |
281 | S>C | No |
ClinGen TOPMed |
|
|
CA395196617 rs1161582174 |
282 | L>F | No |
ClinGen TOPMed |
|
|
rs1164514527 CA395196622 |
282 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1459589572 CA395196645 |
283 | K>N | No |
ClinGen gnomAD |
|
|
rs1184277906 CA395196638 |
283 | K>R | No |
ClinGen TOPMed |
|
|
rs1296548033 CA395196658 |
284 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1376204942 CA395196671 |
285 | P>L | No |
ClinGen gnomAD |
|
|
rs1241809716 CA395196667 |
285 | P>S | No |
ClinGen TOPMed |
|
|
rs16953331 CA278963697 |
286 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA395196697 rs1309944999 |
287 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA395196714 rs1236442002 |
288 | C>R | No |
ClinGen TOPMed |
|
|
CA395196715 rs1352523016 |
288 | C>Y | No |
ClinGen TOPMed |
|
|
CA7913078 rs575901745 |
291 | T>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs554546441 CA7913077 |
291 | T>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1382663224 CA395196745 |
292 | P>T | No |
ClinGen TOPMed |
|
| TCGA novel | 295 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs936896988 CA278963699 |
297 | A>D | No |
ClinGen TOPMed |
|
|
rs543024044 CA278963700 |
298 | L>P | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs1418169049 CA395196861 |
299 | P>L | No |
ClinGen TOPMed |
|
|
CA7913079 rs769664865 |
301 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7913080 rs772807226 |
303 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1187481562 CA395196982 |
306 | K>N | No |
ClinGen TOPMed |
|
|
rs1240645143 CA395196971 |
306 | K>R | No |
ClinGen gnomAD |
|
|
CA395196998 rs1472058214 |
307 | T>I | No |
ClinGen gnomAD |
|
|
CA395197014 rs1425816424 |
308 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA395197001 rs1414919125 |
308 | P>S | No |
ClinGen gnomAD |
|
|
rs762607372 CA395197024 |
309 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1198498740 CA395197021 |
309 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
rs762607372 CA7913081 |
309 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395197027 rs1181302476 |
310 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA395197078 rs1445656107 |
312 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1402378882 CA395197074 |
312 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA395197122 rs199912699 |
314 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs202169175 CA278963703 |
314 | Y>N | No |
ClinGen TOPMed gnomAD |
|
|
rs199912699 CA278963704 |
314 | Y>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1218714995 CA395197133 |
315 | P>S | No |
ClinGen gnomAD |
|
|
rs1441220051 CA395197181 |
318 | P>T | No |
ClinGen gnomAD |
|
|
rs558197649 CA7913083 |
320 | A>T | No |
ClinGen 1000Genomes ExAC |
|
|
rs759145611 CA7913084 |
320 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395197251 rs1423259732 |
323 | N>I | No |
ClinGen TOPMed gnomAD |
|
|
CA395197256 rs1478230575 |
323 | N>K | No |
ClinGen gnomAD |
|
|
CA395197272 rs1427229911 |
325 | K>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1175322040 CA395197302 |
328 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA278963705 rs916551240 |
328 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1296044627 CA395197312 |
329 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA7913088 rs201066933 |
330 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202193811 CA7913090 |
332 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202193811 CA395197353 |
332 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1314451171 CA395197363 |
333 | T>A | No |
ClinGen gnomAD |
|
|
CA395197380 rs1214907245 |
334 | P>L | No |
ClinGen gnomAD |
|
|
rs1488752536 CA395197410 |
337 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1488752536 CA395197413 |
337 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA395197408 rs1262846783 |
337 | P>S | No |
ClinGen gnomAD |
|
|
CA395197418 rs1398681389 |
338 | S>P | No |
ClinGen TOPMed |
|
|
CA395197442 rs1245169173 |
339 | A>V | No |
ClinGen gnomAD |
|
|
CA7913095 rs772236927 |
340 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745910953 CA7913094 |
340 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA395197458 rs1430428897 |
341 | P>S | No |
ClinGen TOPMed |
|
|
CA395197464 rs1476870394 |
342 | S>A | No |
ClinGen TOPMed |
|
|
CA7913097 rs748143363 |
342 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs1359622105 CA395197473 |
344 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1328982430 CA395197488 |
345 | D>E | No |
ClinGen gnomAD |
|
|
CA395197483 rs1299711721 |
345 | D>H | No |
ClinGen gnomAD |
|
|
CA395197482 rs1299711721 |
345 | D>Y | No |
ClinGen gnomAD |
|
|
CA395197498 rs1435212755 |
347 | L>F | No |
ClinGen gnomAD |
|
|
rs762803157 CA7913100 |
347 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1435212755 CA395197499 |
347 | L>V | No |
ClinGen gnomAD |
|
| TCGA novel | 348 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7913101 rs770559688 |
348 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA395197513 rs1264836507 |
349 | T>I | No |
ClinGen TOPMed |
|
|
CA395197514 rs1264836507 |
349 | T>K | No |
ClinGen TOPMed |
|
|
rs1285791565 CA395197516 |
350 | P>A | No |
ClinGen gnomAD |
|
|
rs1343191950 CA395197518 |
350 | P>H | No |
ClinGen TOPMed |
|
|
rs774105050 CA7913103 |
351 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1059222 CA278963706 |
352 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs758928005 CA395197528 |
352 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7913104 rs758928005 |
352 | K>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395197534 rs1288074261 |
353 | C>G | No |
ClinGen gnomAD |
|
|
CA395197538 rs1179093777 |
353 | C>Y | No |
ClinGen TOPMed |
|
|
CA395197549 rs1413089970 |
355 | C>S | No |
ClinGen TOPMed |
|
|
CA395197553 rs1199691008 |
355 | C>S | No |
ClinGen gnomAD |
|
|
rs1199691008 CA395197552 |
355 | C>Y | No |
ClinGen gnomAD |
|
|
CA7913105 rs540809456 |
356 | S>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA395197557 rs1248480201 |
356 | S>T | No |
ClinGen gnomAD |
|
|
rs1379593974 CA395197562 |
357 | L>I | No |
ClinGen gnomAD |
|
|
rs559321630 CA278963707 |
358 | P>H | No |
ClinGen 1000Genomes |
|
|
CA395197586 rs1440147907 |
360 | H>R | No |
ClinGen gnomAD |
|
|
CA395197590 rs1160078226 |
361 | P>A | No |
ClinGen gnomAD |
|
|
rs1388134970 CA395197593 |
361 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA7913107 rs761249029 |
363 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7913106 rs753086489 |
363 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1356113126 CA395197613 |
364 | M>I | No |
ClinGen TOPMed |
|
|
CA395197610 rs1395982609 |
364 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA395197620 rs1384235031 |
365 | I>M | No |
ClinGen TOPMed |
|
|
rs764761020 CA7913108 |
365 | I>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764761020 CA395197619 |
365 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395197617 rs1443894226 |
365 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1378290996 CA395197621 |
366 | I>V | No |
ClinGen gnomAD |
|
|
CA395197632 rs1282728825 |
367 | S>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1446399240 CA395197642 |
369 | N>D | No |
ClinGen TOPMed |
|
|
rs1210622083 CA395197651 |
370 | N>E | No |
ClinGen gnomAD |
No associated diseases with E9PIF3
No regional properties for E9PIF3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for E9PIF3 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UND3 | NPIPA1 | Nuclear pore complex-interacting protein family member A1 | Homo sapiens (Human) | PR |
| F8WFD2 | NPIPA3 | Nuclear pore complex-interacting protein family member A3 | Homo sapiens (Human) | PR |
| P0DM63 | NPIPA8 | Nuclear pore complex-interacting protein family member A8 | Homo sapiens (Human) | PR |
| E9PKD4 | NPIPA5 | Nuclear pore complex-interacting protein family member A5 | Homo sapiens (Human) | PR |
| E9PJI5 | NPIPA7 | Nuclear pore complex-interacting protein family member A7 | Homo sapiens (Human) | PR |
| A6NJ64 | NPIPB2 | Putative nuclear pore complex-interacting protein family member B2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKLSIVLTP | RFLSHDQGQL | TKELQQHVKS | VTCPCEYLRK | VINTLADHRH | RGTDFGGSPW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLIITVFLRS | YKFAISLCTS | YLCVSFLKTI | FPSQNGHDGS | TDVQQRARRS | NRRRQEGIKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLEDIFTLWR | QVETKVRAKI | CKMKVTTKVN | RHDKINGKRK | TAKEHLRKLS | MKEREHGEKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RQVSEAEENG | KLDMKEIHTY | MEMFQRAQAL | RRRAEDYYRC | KITPSARKPL | CNRVRMAAAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HRHSSGLPYW | PYLTAETLKN | RMGHQPPPPT | QQHSIIDNSL | SLKTPPECLL | TPLPPSALPS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADDNLKTPAE | CLLYPLPPSA | DDNLKTPPEC | LLTPLPPSAP | PSADDNLKTP | PKCVCSLPFH |
| PQRMIISRN |