D3ZW91

PR
Gene name
Poc1b (Wdr51b)
Protein name
POC1 centriolar protein homolog B
Names
WD repeat-containing protein 51B
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

376-449 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for D3ZW91

Entry ID Method Resolution Chain Position Source
AF-D3ZW91-F1 Predicted AlphaFoldDB

No variants for D3ZW91

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for D3ZW91

No associated diseases with D3ZW91

7 regional properties for D3ZW91

Type Name Position InterPro Accession
repeat WD40 repeat 7 - 88 IPR001680-1
repeat WD40 repeat 91 - 298 IPR001680-2
conserved_site WD40 repeat, conserved site 159 - 173 IPR019775-1
conserved_site WD40 repeat, conserved site 201 - 215 IPR019775-2
repeat G-protein beta WD-40 repeat 117 - 131 IPR020472-1
repeat G-protein beta WD-40 repeat 159 - 173 IPR020472-2
repeat G-protein beta WD-40 repeat 201 - 215 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Cytoplasm, cytoskeleton, cilium basal body
  • Cytoplasm, cytoskeleton, spindle pole
  • Component of both mother and daughter centrioles
  • Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
centriole replication The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
retina homeostasis A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8TC44 POC1B POC1 centriolar protein homolog B Homo sapiens (Human) PR
A2CEH0 poc1b POC1 centriolar protein homolog B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MASGPEDPIL ERYFKGHKAA ITSADFSPNC KQIATASWDT FLMLWSLKPH ARAYRYVGHK
70 80 90 100 110 120
DVVTSLQFSP QGNLLASASR DKTVRLWVLD RKGKSSEFKA HTAPVRSVDF SADGQFLVTA
130 140 150 160 170 180
SEDKSIKVWS MYRQRFLYSL YRHTHWVRCA KFSPDGRLIV SCSEDKTIKI WDTTSKQCVN
190 200 210 220 230 240
NFSDSVGFAN FVDFSPNGTC IASAGSDHAV RIWDIRMNRL LQHYQVHSCG VNCLSFHPSG
250 260 270 280 290 300
NSLVTASSDG TVKILDLVEG RLIYTLQGHT GPVFTVSFSK DGELFTSGGA DAQVLVWRTS
310 320 330 340 350 360
FNQVHYRDPS KRNLKRLHLE ASPHLLDIYP RTPHGHEDKR ETIEINPKLE VMDLHSSSPP
370 380 390 400 410 420
VVDVLSFDST TVTDSTCRAV PGKGEDICRY FLNPLLMPEC SSTIMKKKPE DVGDPPSENQ
430 440 450 460 470
RSVPLAVADA LEHIMEQLNI LTQSVSIVEQ RLSLTEDKLK DCLENQQKLF SVIQQKS