AiPD: Autoinhibited Protein Database

B4DJY2

Gene name	TMEM233 (IFITMD2)
Protein name	Transmembrane protein 233
Names	Dispanin subfamily B member 2, DSPB2, Interferon-induced transmembrane domain-containing protein D2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:387890
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-63 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for B4DJY2

Entry ID	Method	Resolution	Chain	Position	Source
AF-B4DJY2-F1	Predicted				AlphaFoldDB

83 variants for B4DJY2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA386619680 rs1406985619	3	Q>*		No	ClinGen TOPMed
CA244913455 rs1032889199	4	Y>H		No	ClinGen TOPMed gnomAD
rs1032889199 CA386619687	4	Y>N		No	ClinGen TOPMed gnomAD
rs1456213913 CA386619696	5	A>D		No	ClinGen TOPMed gnomAD
rs1456213913 CA386619698	5	A>V		No	ClinGen TOPMed gnomAD
rs1302397010 CA386619706	7	S>G		No	ClinGen gnomAD
rs901687720 CA244913460	8	P>L		No	ClinGen TOPMed gnomAD
CA386619716 rs901687720	8	P>R		No	ClinGen TOPMed gnomAD
rs1566092124 CA386619713	8	P>T		No	ClinGen Ensembl
rs995907695 CA244913462	10	F>V		No	ClinGen Ensembl
CA386619753 rs1224493114	13	A>V		No	ClinGen TOPMed gnomAD
CA6820251 rs569870460	14	L>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA244913467 rs754725095	16	S>N		No	ClinGen Ensembl
rs1011239751 CA244913469	16	S>R		No	ClinGen TOPMed gnomAD
CA386619774 rs1566092206	17	S>C		No	ClinGen Ensembl
rs1293027535 CA386619785	18	P>H		No	ClinGen gnomAD
CA244913472 rs761699810	19	E>V		No	ClinGen Ensembl
rs374408351 CA244913474	20	A>T		No	ClinGen ESP TOPMed
rs1593267955 CA386619805	21	N>S		No	ClinGen Ensembl
rs765504106 CA6820253	24	D>G		No	ClinGen ExAC TOPMed gnomAD
CA386619830 rs1409715505	25	D>H		No	ClinGen TOPMed gnomAD
rs1442467814 CA386619847	27	T>P		No	ClinGen gnomAD
rs1426428935 CA386619854	28	E>A		No	ClinGen TOPMed gnomAD
rs1385677168 CA386619853	28	E>K		No	ClinGen TOPMed gnomAD
rs1306128934 CA386619866	29	E>D		No	ClinGen gnomAD
rs1346351087 CA386619859	29	E>K		No	ClinGen TOPMed
rs1353951298 CA386619867	30	D>N		No	ClinGen TOPMed gnomAD
CA6820256 rs565388773	32	P>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1260115039 CA386619892	33	M>I		No	ClinGen gnomAD
rs1452256421 CA386619905	35	K>M		No	ClinGen TOPMed gnomAD
TCGA novel CA386619907 rs1289308676	35	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
CA386619901 rs1377228454	35	K>Q		No	ClinGen TOPMed gnomAD
CA386619906 rs1452256421	35	K>T		No	ClinGen TOPMed gnomAD
rs974301483 CA244913485	37	Y>H		No	ClinGen TOPMed
CA6820257 rs751543382	39	W>G		No	ClinGen ExAC gnomAD
TCGA novel	42	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6820259 rs781018057	43	V>G		No	ClinGen ExAC
CA6820258 rs754912477	43	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1272941642 CA386619976	46	F>V		No	ClinGen gnomAD
CA244913489 rs920158806	48	P>A		No	ClinGen TOPMed
CA244913491 rs930173935	49	A>V		No	ClinGen TOPMed
TCGA novel	52	I>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386620014 rs1234171348	52	I>V		No	ClinGen gnomAD
CA386620025 rs1431738926	53	N>S		No	ClinGen TOPMed
rs902749982 CA244913495	55	V>M		No	ClinGen gnomAD
TCGA novel	58	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	59	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6820272 rs762977471	69	D>N		No	ClinGen ExAC TOPMed gnomAD
CA386522395 rs1408568252	70	G>E		No	ClinGen gnomAD
CA6820274 rs751638814	70	G>R		No	ClinGen ExAC TOPMed gnomAD
CA386522401 rs1566111286	71	D>Y		No	ClinGen Ensembl
rs752467663 CA6820277	73	E>K	Variant assessed as Somatic; 6.551e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA386522477 rs1236810463	75	A>P		No	ClinGen TOPMed
CA386522497 rs1433442439	76	R>K		No	ClinGen gnomAD
rs777520610 CA386522515	77	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6820279 rs777520610	77	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs755987884 CA386522508	77	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA244334495 rs893946632	78	L>F		No	ClinGen Ensembl
rs1325214931 CA386522539	79	G>E		No	ClinGen gnomAD
rs1283429862 CA386522531	79	G>R		No	ClinGen gnomAD
CA386522555 rs757010705	80	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6820281 rs757010705	80	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6820280 rs537113870	80	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371582871 CA6820282	83	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA386522652 rs1217793508	85	V>A		No	ClinGen TOPMed gnomAD
rs1266693288 CA386522665	86	A>V		No	ClinGen gnomAD
CA6820283 rs745431029	88	A>T		No	ClinGen ExAC TOPMed gnomAD
CA386522714 rs1193031621	90	I>V		No	ClinGen gnomAD
CA244334514 rs764198454	92	I>T		No	ClinGen Ensembl
CA386522751 rs1593306101	94	L>F		No	ClinGen Ensembl
rs1003663517 CA244334518	96	I>V		No	ClinGen Ensembl
rs187625128 CA6820284	97	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386522774 rs576666159	98	G>C		No	ClinGen 1000Genomes gnomAD
CA244334527 rs576666159	98	G>S		No	ClinGen 1000Genomes gnomAD
TCGA novel	100	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386522795 rs1458197150	101	C>S		No	ClinGen gnomAD
rs777015322 CA6820285	101	C>W		No	ClinGen ExAC gnomAD
rs1301754846 CA386522803	102	A>E		No	ClinGen gnomAD
CA244334538 rs973290896	103	V>F		No	ClinGen Ensembl
TCGA novel	103	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386522815 rs1164827842	104	H>Q		No	ClinGen gnomAD
CA386522810 rs1566111483	104	H>Y		No	ClinGen Ensembl
rs748460598 CA6820286	105	F>L		No	ClinGen ExAC gnomAD

No associated diseases with B4DJY2

No regional properties for B4DJY2

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for B4DJY2

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IXB3	TRARG1	Trafficking regulator of GLUT4 1	Homo sapiens (Human)	PR
D3Z1U7	Tmem233	Transmembrane protein 233	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSQYAPSPDF	KRALDSSPEA	NTEDDKTEED	VPMPKNYLWL	TIVSCFCPAY	PINIVALVFS
70	80	90	100
IMSLNSYNDG	DYEGARRLGR	NAKWVAIASI	IIGLLIIGIS	CAVHFTRNA