B2RYD2
Gene name |
Esrp1 (Rbm35a) |
Protein name |
Epithelial splicing regulatory protein 1 |
Names |
RNA-binding motif protein 35A, RNA-binding protein 35A |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:500409 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B2RYD2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B2RYD2-F1 | Predicted | AlphaFoldDB |
No variants for B2RYD2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B2RYD2 | |||||
No associated diseases with B2RYD2
3 regional properties for B2RYD2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 225 - 302 | IPR000504-1 |
| domain | RNA recognition motif domain | 326 - 406 | IPR000504-2 |
| domain | RNA recognition motif domain | 446 - 521 | IPR000504-3 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| alternative mRNA splicing, via spliceosome | The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
| branching involved in salivary gland morphogenesis | The process in which the branching structure of the salivary gland is generated and organized. |
| epithelial cell proliferation | The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. |
| epithelial tube branching involved in lung morphogenesis | The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. |
| positive regulation of epithelial cell proliferation | Any process that activates or increases the rate or extent of epithelial cell proliferation. |
| regulation of inner ear auditory receptor cell fate specification | Any process that mediates the specification of a cell into an auditory hair cell. |
| regulation of RNA splicing | Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTASPDYLVV | LFGITAGATG | AKLGSDEKEL | ILLLWKVVDL | ANKKVGQLHE | VLVRPDQLEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TEDCKEETKI | DAENLSSAPQ | LDQALRQFNQ | SVSNELNIGV | GTSFCLCTDG | QLHVRQILHP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EASKKNVLLP | ECFYSFFDLR | KEFKKCCPGS | PDLDKLDVAA | MAESLNFEKN | DSMSRYGASQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VEDMGNIILA | MISEPYNHRF | SDPERVNYKF | ESGTCSKTEL | IDGNTVVRAR | GLPWQSSDQD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IARFFKGLNI | AKGGAALCLN | AQGRRNGEAL | VRFVSEEHRD | LALQRHKHHM | GTRYIEVYKA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGEDFLKIAG | GTSNEVAQFL | SKENQVIVRM | RGLPFTATAE | EVVAFFGQHC | PITGGKEGIL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FVTYPDGRPT | GDAFVLFACE | EYAQNALRKH | KDLLGKRYIE | LFRSTAAEVQ | QVLNRFSSAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LIPLPTAPII | PVLPQQFVPP | TNVRDCVRLR | GLPYAATIED | ILDFLGEFST | DIRTHGVHMV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LNHQGRPSGD | AFIQMKSTDR | AFMAAQKYHK | KTMKDRYVEV | FQCSAEEMNF | VLMGGTLNRN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GLSPPPCLSP | PSYTFPAPAA | VIPTEAAIYQ | PSLLLNPRAL | QPSTAYYPAG | TQLFMNYTAY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YPSPPGSPNS | LGYFPTAANL | SSVPPQPGTV | VRMQGLAYNT | GVKEILNFFQ | GYQYATEDGL |
| 670 | |||||
| VHANDQARTV | PKEWVCI |