B2D6P4
Gene name |
tlf-1 (F39H11.2) |
Protein name |
TATA box-binding protein-like 1 |
Names |
TBP-like , TBP-like factor , CeTLF |
Species |
Homo sapiens (Human) |
KEGG Pathway |
cel:CELE_F39H11.2 |
EC number |
2.3.2.23: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
264-446 (TATA binding domain) |
Relief mechanism |
Partner binding, Others |
Assay |
|
Accessory elements
No accessory elements
References
- Chasman DI et al. (1993) "Crystal structure of yeast TATA-binding protein and model for interaction with DNA", Proceedings of the National Academy of Sciences of the United States of America, 90, 8174-8
- Jackson-Fisher AJ et al. (1999) "A role for TBP dimerization in preventing unregulated gene expression", Molecular cell, 3, 717-27
- Chitikila C et al. (2002) "Interplay of TBP inhibitors in global transcriptional control", Molecular cell, 10, 871-82
Autoinhibited structure
Activated structure
1 structures for B2D6P4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B2D6P4-F1 | Predicted | AlphaFoldDB |
No variants for B2D6P4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B2D6P4 | |||||
1 associated diseases with B2D6P4
[MIM: 616435]: Fanconi anemia complementation group T (FANCT)
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269|PubMed:26046368}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269|PubMed:26046368}. Note=The disease is caused by variants affecting the gene represented in this entry.
1 regional properties for B2D6P4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 5 - 159 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.23 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| general transcription initiation factor activity | A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription initiation | The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P26356 | TBP1 | TATA-box-binding protein 1 | Triticum aestivum (Wheat) | PR |
| Q02879 | TBP2 | TATA-box-binding protein 2 | Triticum aestivum (Wheat) | PR |
| Q2HJ52 | TBP | TATA-box-binding protein | Bos taurus (Bovine) | PR |
| O13270 | TBP | TATA-box-binding protein | Gallus gallus (Chicken) | PR |
| A6H907 | TBPL2 | TATA box-binding protein-like 2 | Pan troglodytes (Chimpanzee) | PR |
| Q27896 | Trf | TBP-related factor | Drosophila melanogaster (Fruit fly) | PR |
| Q6SJ96 | TBPL2 | TATA box-binding protein-like 2 | Homo sapiens (Human) | PR |
| P20226 | TBP | TATA-box-binding protein | Homo sapiens (Human) | EV |
| P50158 | TBP1 | TATA-box-binding protein 1 | Zea mays (Maize) | PR |
| Q6SJ95 | Tbpl2 | TATA box-binding protein-like 2 | Mus musculus (Mouse) | PR |
| P29037 | Tbp | TATA-box-binding protein | Mus musculus (Mouse) | PR |
| P26357 | TBP | TATA-box-binding protein | Solanum tuberosum (Potato) | PR |
| A6H909 | Tbpl2 | TATA box-binding protein-like 2 | Rattus norvegicus (Rat) | PR |
| Q8W0W4 | TBP2 | TATA-binding protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| O45211 | Tbp | TATA-box-binding protein | Bombyx mori (Silk moth) | PR |
| Q42808 | TBP1 | TATA-box-binding protein | Glycine max (Soybean) (Glycine hispida) | PR |
| P28148 | TBP2 | TATA-box-binding protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P28147 | TBP1 | TATA-box-binding protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28GG8 | tbp | TATA-box-binding protein | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28DH2 | tbpl2 | TATA box-binding protein-like 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7SXL3 | tbp | TATA-box-binding protein | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1JPY4 | tbpl2 | TATA box-binding protein-like 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRASRLKRE | LHMLATEPPP | GITCWQDKDQ | MDDLRAQILG | GANTPYEKGV | FKLEVIIPER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YPFEPPQIRF | LTPIYHPNID | SAGRICLDVL | KLPPKGAWRP | SLNIATVLTS | IQLLMSEPNP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DDPLMADISS | EFKYNKPAFL | KNARQWTEKH | ARQKQKADEE | EMLDNLPEAG | DSRVHNSTQK |
| 190 | |||||
| RKASQLVGIE | KKFHPDV |