AiPD: Autoinhibited Protein Database

Gene name	TDP2 (TTRAP)
Protein name	Tyrosyl-DNA phosphodiesterase 2
Names	Tyr-DNA phosphodiesterase 2, 5'-tyrosyl-DNA phosphodiesterase, 5'-Tyr-DNA phosphodiesterase, TRAF and TNF receptor-associated protein
Species	Bos taurus (Bovine)
KEGG Pathway	bta:507579
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-142 (Predicted disordered autoinhibitory region) PR

1-142 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A7YWI9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs467238075	3	R>G	No	EVA
rs480869215	4	N>T	No	EVA
rs449640427	10	G>V	No	EVA
rs469655122	11	P>A	No	EVA
rs469655122	11	P>T	No	EVA
rs436807486	13	A>G	No	EVA
rs464231471	17	E>G	No	EVA
rs456891891	17	E>K	No	EVA
rs432820786	18	G>W	No	EVA
rs452924304	19	E>G	No	EVA
rs452924304	19	E>V	No	EVA
rs441751744	25	R>G	No	EVA
rs521073883	31	E>K	No	EVA
rs455502361	34	S>A	No	EVA
rs469262559	35	V>I	No	EVA
rs475473934	36	A>P	No	EVA
rs444407842	37	S>R	No	EVA
rs458095080	38	C>W	No	EVA
rs478248003	39	D>N	No	EVA
rs440528727	44	Q>E	No	EVA
rs435371365	61	Y>S	No	EVA
rs455332831	62	F>S	No	EVA
rs475510749	67	E>Q	No	EVA
rs437903657	68	E>A	No	EVA
rs451488886	70	A>G	No	EVA
rs471843943	78	L>P	No	EVA
rs436402364	78	L>V	No	EVA
rs440370525	79	S>Y	No	EVA
rs474263270	82	G>V	No	EVA
rs443054940	83	S>P	No	EVA
rs479608691	97	S>I	No	EVA
rs133195122	116	F>L	No	EVA
rs209538070	144	L>S	No	EVA
rs721393153	168	S>N	No	EVA
rs467811433	220	N>T	No	EVA
rs447583595	220	N>Y	No	EVA
rs450130841	221	E>D	No	EVA
rs134633974	243	F>L	No	EVA
rs439468444	263	G>A	No	EVA
rs470662438	275	C>*	No	EVA
rs473198319	278	L>*	No	EVA
rs459630738	278	L>V	No	EVA
rs442144478	281	N>D	No	EVA
rs482494008	306	N>I	No	EVA
rs450960548	316	R>L	No	EVA
rs478549374	324	A>G	No	EVA
rs458460744	324	A>P	No	EVA
rs447163592	325	A>P	No	EVA
rs465798387	351	S>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Endonuclease/exonuclease/phosphatase	120 - 353	IPR005135

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, PML body Nucleus, nucleolus Cytoplasm	Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
aggresome	An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
PML body	A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.

Name	Definition
5'-tyrosyl-DNA phosphodiesterase activity	Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.
magnesium ion binding	Binding to a magnesium (Mg) ion.
manganese ion binding	Binding to a manganese ion (Mn).
nuclease activity	Catalysis of the hydrolysis of ester linkages within nucleic acids.
single-stranded DNA binding	Binding to single-stranded DNA.
tyrosyl-RNA phosphodiesterase activity	Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.

Name	Definition
double-strand break repair	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
neuron development	The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O95551	TDP2	Tyrosyl-DNA phosphodiesterase 2	Homo sapiens (Human)	PR
Q9JJX7	Tdp2	Tyrosyl-DNA phosphodiesterase 2	Mus musculus (Mouse)	PR
Q3T1H5	Tdp2	Tyrosyl-DNA phosphodiesterase 2	Rattus norvegicus (Rat)	PR