A7XV07
Gene name |
Skint8 |
Protein name |
Selection and upkeep of intraepithelial T-cells protein 8 |
Names |
Skint-8 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:639774 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A7XV07
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A7XV07-F1 | Predicted | AlphaFoldDB |
41 variants for A7XV07
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs583284065 | 2 | M>V | No | EVA | |
| rs3388702741 | 25 | S>L | No | EVA | |
| rs256840014 | 36 | H>Y | No | EVA | |
| rs233870393 | 46 | E>V | No | EVA | |
| rs27500608 | 101 | I>F | No | EVA | |
| rs27500607 | 120 | P>L | No | EVA | |
| rs3388702190 | 188 | L>F | No | EVA | |
| rs3394641193 | 216 | I>N | No | EVA | |
| rs239243078 | 250 | P>H | No | EVA | |
| rs3388687775 | 251 | F>S | No | EVA | |
| rs1132391278 | 252 | S>N | No | EVA | |
| rs31814054 | 254 | L>I | No | EVA | |
| rs32196920 | 254 | L>R | No | EVA | |
| rs31814054 | 254 | L>V | No | EVA | |
| rs27500597 | 255 | S>A | No | EVA | |
| rs31968692 | 255 | S>L | No | EVA | |
| rs27500597 | 255 | S>T | No | EVA | |
| rs6224833 | 258 | L>F | No | EVA | |
| rs6224833 | 258 | L>V | No | EVA | |
| rs221810509 | 263 | P>L | No | EVA | |
| rs221810509 | 263 | P>Q | No | EVA | |
| rs6224866 | 264 | F>L | No | EVA | |
| rs264355717 | 267 | S>C | No | EVA | |
| rs264355717 | 267 | S>Y | No | EVA | |
| rs580692678 | 268 | F>C | No | EVA | |
| rs584337305 | 271 | S>N | No | EVA | |
| rs6224903 | 271 | S>R | No | EVA | |
| rs242411019 | 272 | Q>R | No | EVA | |
| rs27500589 | 284 | P>S | No | EVA | |
| rs27500588 | 286 | V>M | No | EVA | |
| rs50396813 | 288 | S>F | No | EVA | |
| rs237829340 | 291 | V>F | No | EVA | |
| rs264185868 | 293 | I>M | No | EVA | |
| rs27500587 | 293 | I>T | No | EVA | |
| rs239294634 | 295 | H>Y | No | EVA | |
| rs579208644 | 298 | V>I | No | EVA | |
| rs27500585 | 312 | Y>H | No | EVA | |
| rs27500569 | 326 | N>D | No | EVA | |
| rs27500568 | 347 | T>I | No | EVA | |
| rs45705621 | 374 | L>P | No | EVA | |
| rs47894347 | 380 | R>H | No | EVA |
No associated diseases with A7XV07
4 regional properties for A7XV07
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Immunoglobulin subtype | 34 - 141 | IPR003599 |
| domain | Immunoglobulin-like domain | 26 - 141 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 159 - 233 | IPR007110-2 |
| domain | Immunoglobulin V-set domain | 35 - 140 | IPR013106 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of cytokine production | Any process that modulates the frequency, rate, or extent of production of a cytokine. |
| T cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7XV04 | Skint7 | Selection and upkeep of intraepithelial T-cells protein 7 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMKPEFSHFF | GFCVYFLFLQ | VMASSEKLRV | TTPTRHLLAR | VGGQAELSCQ | VIPPHSVMHM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVRWFRSGHS | QPVYLYRGGH | KMSEEAAPEY | ANRTEFVKEA | IGEGKVSLRI | YNINILDDGP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YQCSFNDSGF | IDVAIMNLNV | TAVGLETEIH | VQAPDADGVM | VECNTGGWFP | RPQMEWRDSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GATLPHSLKS | YSQDEARFFH | MKMTLLLTNM | SHGSIICCIS | NPVTGEEKQT | SIILANELFN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QDYLWVGIFP | FSVLSLILFG | VLPFINSFFR | SQGCASGCLS | KCLPVVTSWP | VQIVHFLVCS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GVLFAVYLPH | RYRVSLSDPQ | FPLYNNWITE | LLIVILFLTI | CFVLPITVLL | LIKLSPTCLA |
| 370 | 380 | 390 | |||
| KWEKNKDDIM | DSQLGLGKAR | EASTLYEEQS | RKSWEQEK |