A7XV04

PR
Gene name
Skint7
Protein name
Selection and upkeep of intraepithelial T-cells protein 7
Names
Skint-7
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:328505
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

338-395 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7XV04

Entry ID Method Resolution Chain Position Source
AF-A7XV04-F1 Predicted AlphaFoldDB

37 variants for A7XV04

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388706137 6 F>L No EVA
rs3388707572 7 F>L No EVA
rs27484832 7 F>S No EVA
rs3388679688 9 F>L No EVA
rs254912473 24 S>F No EVA
rs579164756 29 R>K No EVA
rs1132886732 36 H>Y No EVA
rs3388696359 46 E>G No EVA
rs3388696359 46 E>V No EVA
rs1134658981 91 A>V No EVA
rs1132491867 92 N>K No EVA
rs1132205779 93 R>L No EVA
rs1131999869 96 F>Y No EVA
rs1131706885 98 K>E No EVA
rs27484822 101 I>F No EVA
rs1132214926 103 E>D No EVA
rs1133766805 103 E>K No EVA
rs1134112552 107 S>A No EVA
rs3388702219 109 R>L No EVA
rs1133492069 114 N>S No EVA
rs27484821 120 P>L No EVA
rs585300342 127 G>A No EVA
rs585300342 127 G>D No EVA
rs1134292140 127 G>R No EVA
rs32943071 133 A>V No EVA
rs222404776 185 P>L No EVA
rs3394590065 226 E>NTANDAAM* No EVA
rs27484801 243 R>H No EVA
rs27484800 258 S>F No EVA
rs27484799 271 T>K No EVA
rs49592699 274 A>E No EVA
rs27484787 281 C>W No EVA
rs27484786 284 V>M No EVA
rs27484785 292 I>T No EVA
rs27484784 301 T>A No EVA
rs3394740159 311 S>C No EVA
rs3394690039 312 R>* No EVA

No associated diseases with A7XV04

3 regional properties for A7XV04

Type Name Position InterPro Accession
domain Immunoglobulin subtype 34 - 141 IPR003599
domain Immunoglobulin-like domain 26 - 141 IPR007110
domain Immunoglobulin V-set domain 35 - 140 IPR013106

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

2 GO annotations of biological process

Name Definition
regulation of cytokine production Any process that modulates the frequency, rate, or extent of production of a cytokine.
T cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A7XV07 Skint8 Selection and upkeep of intraepithelial T-cells protein 8 Mus musculus (Mouse) PR
10 20 30 40 50 60
MMKPEFFCFS GFCVYFLFLQ VVVSSEKLRV TTPTRHLLAR VGGQAELSCQ VIPPHSVMHM
70 80 90 100 110 120
EVRWFRSGHS QPVYLYRGGH KMSEEAAPEY ANRTEFVKEA IGEGKVSLRI HNINILDDGP
130 140 150 160 170 180
YQCSFNGSGF IDAAIMNLNV TAVGLETEIH VQAPDADGVM VECNSGGWFP RPQMEWRDSK
190 200 210 220 230 240
GATLPHSLKS YSQDEARFFY MKMTLLLTNM SHGSIICCIF NPVTGEEKQT SIILANELFN
250 260 270 280 290 300
RDRIWMESLA SIVWIMLSVY ILYIICFYWR TGCASGCLSK CFCVVTSWPV QIVHLLFCTG
310 320 330 340 350 360
TFFAIYLPHR SRVSLSDPQF PLYNNWITEL LFVILFLTIC FALPIILLFI QFQFTSLTKW
370 380 390
EKNKDGIMDQ PRLGKAHETS SLYRKKTGKS WEQEK