A6H7C9

PR
Gene name
CEP19
Protein name
Centrosomal protein of 19 kDa
Names
Cep19
Species
Bos taurus (Bovine)
KEGG Pathway
bta:613916
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6H7C9

Entry ID Method Resolution Chain Position Source
AF-A6H7C9-F1 Predicted AlphaFoldDB

4 variants for A6H7C9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs460014482 8 C>W No EVA
rs719752649 75 S>T No EVA
rs521330110 92 Q>H No EVA
rs477295160 95 R>W No EVA

No associated diseases with A6H7C9

11 regional properties for A6H7C9

Type Name Position InterPro Accession
domain Cadherin-like 54 - 133 IPR002126-1
domain Cadherin-like 134 - 242 IPR002126-2
domain Cadherin-like 242 - 347 IPR002126-3
domain Cadherin-like 348 - 561 IPR002126-4
domain Cadherin-like 580 - 671 IPR002126-5
domain Cadherin, N-terminal 32 - 112 IPR013164
conserved_site Cadherin conserved site 230 - 240 IPR020894-1
conserved_site Cadherin conserved site 335 - 345 IPR020894-2
conserved_site Cadherin conserved site 439 - 449 IPR020894-3
conserved_site Cadherin conserved site 549 - 559 IPR020894-4
domain Cadherin, cytoplasmic C-terminal domain 685 - 768 IPR032455

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Cytoplasm, cytoskeleton, spindle pole
  • Cytoplasm, cytoskeleton, cilium basal body
  • Associates with the mother centriole in early interphase
  • Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase
  • Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
microtubule anchoring at centrosome Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome.
vesicle targeting, trans-Golgi to periciliary membrane compartment The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96LK0 CEP19 Centrosomal protein of 19 kDa Homo sapiens (Human) PR
Q9CQA8 Cep19 Centrosomal protein of 19 kDa Mus musculus (Mouse) PR
Q9QZX9 Cep19 Centrosomal protein of 19 kDa Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MMCTAKKCGI RFQPPAIILI YENEIKGKSR QRIMPVRNFS KYSDCSRAAE QLKNNPRHKG
70 80 90 100 110 120
YLEQVSLKQL EKLFSFLRGN LWGQSLAETM EQIQRETTID PEEDLNKLDD KELAKRKSIM
130 140 150 160
DELFEKNQKK KDDPNFVYDI EVEFPQDEQL QSCGWDTESA EEF