Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5D9C6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5D9C6-F1 | Predicted | AlphaFoldDB |
77 variants for A5D9C6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs451052823 | 33 | S>L | No | EVA | |
| rs468310772 | 44 | F>S | No | EVA | |
| rs446476686 | 50 | E>G | No | EVA | |
| rs457721943 | 64 | T>P | No | EVA | |
| rs468702831 | 105 | R>P | No | EVA | |
| rs435202145 | 105 | R>W | No | EVA | |
| rs446568347 | 106 | P>R | No | EVA | |
| rs464185069 | 107 | D>G | No | EVA | |
| rs434464365 | 107 | D>Y | No | EVA | |
| rs445647273 | 108 | Y>H | No | EVA | |
| rs481841854 | 108 | Y>S | No | EVA | |
| rs463690633 | 109 | D>N | No | EVA | |
| rs448240833 | 110 | F>S | No | EVA | |
| rs459473496 | 111 | S>T | No | EVA | |
| rs440509758 | 112 | T>K | No | EVA | |
| rs473281785 | 113 | A>P | No | EVA | |
| rs458011737 | 114 | R>P | No | EVA | |
| rs439576116 | 115 | S>R | No | EVA | |
| rs475778595 | 115 | S>T | No | EVA | |
| rs468168206 | 116 | H>Q | No | EVA | |
| rs475286473 | 117 | E>D | No | EVA | |
| rs435842648 | 117 | E>G | No | EVA | |
| rs434499581 | 118 | F>L | No | EVA | |
| rs453505966 | 118 | F>S | No | EVA | |
| rs464270897 | 119 | S>G | No | EVA | |
| rs464270897 | 119 | S>R | No | EVA | |
| rs445732965 | 121 | E>G | No | EVA | |
| rs469720978 | 123 | S>G | No | EVA | |
| rs481378328 | 124 | L>P | No | EVA | |
| rs465830772 | 125 | S>R | No | EVA | |
| rs447385888 | 125 | S>T | No | EVA | |
| rs476975764 | 126 | W>R | No | EVA | |
| rs471228898 | 127 | V>L | No | EVA | |
| rs443344584 | 128 | V>G | No | EVA | |
| rs436010298 | 129 | N>K | No | EVA | |
| rs454579557 | 129 | N>T | No | EVA | |
| rs465552673 | 131 | V>A | No | EVA | |
| rs453891900 | 132 | N>T | No | EVA | |
| rs432242881 | 134 | S>G | No | EVA | |
| rs465045679 | 138 | A>D | No | EVA | |
| rs437757731 | 142 | D>G | No | EVA | |
| rs449787177 | 142 | D>H | No | EVA | |
| rs470292820 | 144 | K>N | No | EVA | |
| rs448519412 | 155 | D>N | No | EVA | |
| rs481420685 | 158 | I>V | No | EVA | |
| rs135473276 | 163 | C>* | No | EVA | |
| rs448030398 | 163 | C>R | No | EVA | |
| rs459182408 | 164 | D>A | No | EVA | |
| rs519672868 | 166 | Y>* | No | EVA | |
| rs460041497 | 169 | N>S | No | EVA | |
| rs456376440 | 175 | D>A | No | EVA | |
| rs474053497 | 177 | F>L | No | EVA | |
| rs455497810 | 178 | G>W | No | EVA | |
| rs436512240 | 181 | G>A | No | EVA | |
| rs466285718 | 183 | L>P | No | EVA | |
| rs454197513 | 185 | S>A | No | EVA | |
| rs454197513 | 185 | S>P | No | EVA | |
| rs432351954 | 186 | F>L | No | EVA | |
| rs465332806 | 188 | Y>S | No | EVA | |
| rs450342095 | 189 | F>L | No | EVA | |
| rs483314693 | 190 | F>Y | No | EVA | |
| rs467970364 | 191 | Y>* | No | EVA | |
| rs449379625 | 194 | R>L | No | EVA | |
| rs478985196 | 196 | K>N | No | EVA | |
| rs460078265 | 198 | I>L | No | EVA | |
| rs438419471 | 206 | I>F | No | EVA | |
| rs477894880 | 206 | I>S | No | EVA | |
| rs444944373 | 211 | Y>S | No | EVA | |
| rs477919792 | 212 | T>P | No | EVA | |
| rs462554589 | 226 | E>K | No | EVA | |
| rs444030267 | 230 | E>G | No | EVA | |
| rs462046866 | 232 | E>G | No | EVA | |
| rs480247764 | 232 | E>K | No | EVA | |
| rs473237847 | 233 | E>* | No | EVA | |
| rs457928705 | 233 | E>A | No | EVA | |
| rs444481030 | 255 | V>A | No | EVA | |
| rs474050926 | 256 | P>S | No | EVA |
No associated diseases with A5D9C6
No regional properties for A5D9C6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A5D9C6 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA polymerase III core binding | Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of transcription by RNA polymerase III | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLLENSSFE | AINSQLTVET | GDAHIIGRIE | SYSCKMAGDD | KHMFKQFCQE | GQPHVLEALS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPQTSGLSPS | RLSKSQGGED | EGPLSDKCSR | KTLFYLIATL | NESFRPDYDF | STARSHEFSR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EPSLSWVVNA | VNCSLFSAVR | EDFKALKPQL | WNAVDEEICL | AECDIYSYNP | DLDSDPFGED |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GSLWSFNYFF | YNKRLKRIVF | FSCRSISGST | YTPSEAGNEL | DMELGEEDEE | EEEESGGGGS |
| 250 | |||||
| EGGPEEPGTM | EEDRVPVICM |