A4Q9F0
PR
Gene name |
Ttll7 |
Protein name |
Tubulin polyglutamylase TTLL7 |
Names |
Tubulin--tyrosine ligase-like protein 7, mTTLL7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70892 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A4Q9F0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A4Q9F0-F1 | Predicted | AlphaFoldDB |
No variants for A4Q9F0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A4Q9F0 | |||||
No associated diseases with A4Q9F0
No regional properties for A4Q9F0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A4Q9F0 | |||
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| 9+0 non-motile cilium | A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-tubulin binding | Binding to the microtubule constituent protein alpha-tubulin. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| beta-tubulin binding | Binding to the microtubule constituent protein beta-tubulin. |
| metal ion binding | Binding to a metal ion. |
| tubulin binding | Binding to monomeric or multimeric forms of tubulin, including microtubules. |
| tubulin-glutamic acid ligase activity | Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| protein polyglutamylation | The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSLPQDGVI | QGSSPVDLGT | ELPYQCTMKR | KVRKKKKKGI | ITANVAGTKF | EIVRLVIDEM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFMKTPDEDE | TSNLIWCDAA | VQQEKITDLQ | NYQRINHFPG | MGEICRKDFL | ARNMTKMIKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RPMDYTFVPR | TWIFPSEYTQ | FQNYVKELKK | KRKQKTFIVK | PANGAMGHGI | SLIRNGDKVP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQDHLIVQEY | IEKPFLMEGY | KFDLRIYILV | TSCDPLKIFL | YHDGLVRMGT | EKYIPPNESN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTQLYMHLTN | YSVNKHNERF | ERNETEDKGS | KRSIKWFTEF | LQANQHDVTK | FWSDISELVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KTLIVAEPHV | LHAYRMCRPG | QPPGSESVCF | EVLGFDILLD | RKLKPWLLEI | NRAPSFGTDQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KIDYDVKRGV | LLNALKLLNI | RTSDKRKNLA | KQKAEAQRRL | YGQNPVRRLS | PGSSDWEQQR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HQLERRKEEL | KERLLQVRKQ | VSQEEHENRH | MGNYRRIYPP | EDKALLEKYE | GLLAVAFQTF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSGRAASFQR | EMNNPLKKMR | EEDLLDLLEQ | CEIDDEKLMG | KTGRVRGPKP | LCCMPECAEV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TKKQKYYGSS | DSSYDSSSSS | SNSELDENEK | ELCQKRLDQV | PYSLKHTSHC | KIIQQPSGSH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NLIYSESPVY | LTTLVFLSEF | PDSMRRSVSC | PRSISAHLPS | RGDVRPFSSQ | QVIPLARPTS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ASRSHSLNRA | SSYARHLPHG | SDTGSTNTLN | ESLRQLKTKE | QEDDLTSQTL | FVLKDMRIRF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PGKSDAESEL | LIEDIMDNWK | HYKTKVASYW | LIKLDSVKQR | KVLDIVKSSI | RTVLPRIWRV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PDAEELSLYR | IFNRVFNRLL | WSHGQGLWSC | FCDSGSSWES | IFSKSPEVVT | PLQLQCCQRL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VELCKQCLLV | VYKYTTETRG | PISGIGPDWG | NSRYLLPGST | QFLMRSPLYN | MKYNSPGMTR |
| 910 | |||||
| SNVLFTSRYG | RL |