A4III8

PR
Gene name
ttc26 (ift56)
Protein name
Intraflagellar transport protein 56
Names
Tetratricopeptide repeat protein 26, TPR repeat protein 26
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100125003
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4III8

Entry ID Method Resolution Chain Position Source
AF-A4III8-F1 Predicted AlphaFoldDB

No variants for A4III8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4III8

No associated diseases with A4III8

2 regional properties for A4III8

Type Name Position InterPro Accession
domain Translation elongation factor EFTs/EF1B, dimerisation 70 - 291 IPR014039
conserved_site Translation elongation factor Ts, conserved site 11 - 26 IPR018101

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
ciliary base Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
intraciliary transport particle B The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.

1 GO annotations of molecular function

Name Definition
intraciliary transport particle B binding Binding to an intraciliary transport particle B (IFT B) complex.

8 GO annotations of biological process

Name Definition
axoneme assembly The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
intraciliary anterograde transport The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins.
intraciliary transport The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
intraciliary transport involved in cilium assembly The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A0AVF1 TTC26 Intraflagellar transport protein 56 Homo sapiens (Human) PR
Q8BS45 Ttc26 Intraflagellar transport protein 56 Mus musculus (Mouse) PR
Q5U2N8 Ttc26 Intraflagellar transport protein 56 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MMLSRAKPAV GNEVQQIDKK KKKGKKVPRL DELLAQRDFT GAITLLEFKR QVGESEEDTE
70 80 90 100 110 120
LWIGYCSFHL GDYKRSLEVF KALSQQEGCN PDVWVNLACT SFFLGMYKEA DEAANKAPKS
130 140 150 160 170 180
RLQNRLLFHL AHKFNDEKRL MVFHQNLQDV IEDQLSLASI HYMRSHYQEA IDIYKRILLE
190 200 210 220 230 240
NRDFLALNVY VALCYYKLDY YDVSQEVLAV YLQQVPDSTI ALNLKACNHF RLYNGKAAEA
250 260 270 280 290 300
ELKGLMDSTS SPIEFAKELI KHNLVVFRAG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
310 320 330 340 350 360
VQEAFNLIKD LEPSTPQEYI LKGVVNASLG QELGSRDHLK IAQQFFQLVG GSASECDTIP
370 380 390 400 410 420
GRQCMASCFF LLRQFDDVLI YLNSIKSYFY NDDTFNFNYA QAKAAVGNYK EAEEVFLLIQ
430 440 450 460 470 480
NEKIKNDYTY LSWLARCYIM NKKPRMAWEL YLKMETSGES FSLLQLIAND CYKMGHFYYA
490 500 510 520 530 540
AKAFDILERL DPSPEYWEGK RGACVGIFQM ILAGREPKET LREVLNLLRS TGNTQVEYII
550
RILKKWGKEN RVPV