AiPD: Autoinhibited Protein Database

Gene name	LAMP5
Protein name	Lysosome-associated membrane glycoprotein 5
Names	Lysosome-associated membrane protein 5, LAMP-5
Species	Bos taurus (Bovine)
KEGG Pathway	bta:513094
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-71 (Predicted disordered autoinhibitory region) PR

1-71 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A4FV27-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs469122147	8	L>H	No	EVA
rs432988076	9	L>I	No	EVA
rs109464374	11	V>G	No	EVA
rs451580386	12	D>E	No	EVA
rs433913439	16	V>D	No	EVA
rs473863821	19	M>K	No	EVA
rs465703914	29	A>E	No	EVA
rs455111526	30	E>Q	No	EVA
rs470410204	30	E>V	No	EVA
rs452747271	43	P>H	No	EVA
rs435384150	86	D>V	No	EVA
rs457127877	94	E>D	No	EVA
rs469267690	95	V>G	No	EVA
rs451302801	108	V>G	No	EVA
rs473020063	111	V>G	No	EVA
rs876389801	115	Y>S	No	EVA
rs476137968	116	A>T	No	EVA
rs456090671	125	S>R	No	EVA
rs471765105	126	H>N	No	EVA
rs210100051	129	P>S	No	EVA
rs454221754	132	P>L	No	EVA
rs443130779	136	W>*	No	EVA
rs461328584	139	S>R	No	EVA
rs476646797	141	V>I	No	EVA
rs443710789	151	T>P	No	EVA
rs459043941	155	D>E	No	EVA
rs470415111	168	H>P	No	EVA
rs437472062	169	L>P	No	EVA
rs464514960	174	T>P	No	EVA
rs453324080	175	P>S	No	EVA
rs1117237899	177	G>R	No	EVA
rs435718765	177	G>V	No	EVA
rs476235165	183	Q>H	No	EVA
rs443450369	186	Q>R	No	EVA
rs458685983	187	T>P	No	EVA
rs470365024	200	T>P	No	EVA
rs440791325	201	M>L	No	EVA
rs459389057	214	I>L	No	EVA
rs481165938	216	D>N	No	EVA
rs448199499	220	S>R	No	EVA
rs461082928	223	H>Y	No	EVA
rs476359941	227	V>E	No	EVA
rs458582702	228	D>A	No	EVA
rs477122092	228	D>E	No	EVA
rs443174240	228	D>H	No	EVA
rs440913549	231	E>D	No	EVA
rs459862081	232	Q>E	No	EVA
rs459862081	232	Q>K	No	EVA
rs481626909	233	L>M	No	EVA
rs482557159	234	E>D	No	EVA
rs470476506	234	E>G	No	EVA
rs448755989	234	E>K	No	EVA
rs445981866	249	I>F	No	EVA
rs434841122	254	V>G	No	EVA
rs453386427	256	Y>S	No	EVA
rs465750917	263	T>P	No	EVA
rs436147461	264	A>P	No	EVA
rs476298510	266	Q>K	No	EVA
rs443515237	267	V>L	No	EVA
rs451982938	268	Q>H	No	EVA
rs470622721	272	D>A	No	EVA
rs440854761	279	M>R	No	EVA
rs459452450	281	G>Y	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for A4FV27

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle membrane ; Single-pass type I membrane protein Cell membrane ; Single-pass type I membrane protein Cell projection, dendrite Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein Cell projection, growth cone membrane ; Single-pass type I membrane protein Early endosome membrane ; Single-pass type I membrane protein Recycling endosome Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein Endosome membrane ; Single-pass type I membrane protein	Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity) Colocalizes with UNC93B1 in large endosomal intracellular vesicles (By similarity) Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (By similarity) Associates with cortical membranes (By similarity) Localizes mostly in cytoplasmic vesicles of neuronal cell body Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoplasmic vesicle membrane	The lipid bilayer surrounding a cytoplasmic vesicle.
dendrite membrane	The portion of the plasma membrane surrounding a dendrite.
early endosome membrane	The lipid bilayer surrounding an early endosome.
endoplasmic reticulum-Golgi intermediate compartment membrane	The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
endosome membrane	The lipid bilayer surrounding an endosome.
growth cone membrane	The portion of the plasma membrane surrounding a growth cone.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane	The lipid bilayer surrounding a late endosome.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome membrane	The lipid bilayer surrounding a recycling endosome.
synaptic vesicle membrane	The lipid bilayer surrounding a synaptic vesicle.

Name	Definition
No GO annotations for molecular function

Name	Definition
establishment of protein localization to organelle	The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UJQ1	LAMP5	Lysosome-associated membrane glycoprotein 5	Homo sapiens (Human)	PR