A4FUC0
Gene name |
MRPL37 |
Protein name |
39S ribosomal protein L37, mitochondrial |
Names |
L37mt, MRP-L37 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:510127 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A4FUC0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A4FUC0-F1 | Predicted | AlphaFoldDB |
89 variants for A4FUC0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs463737718 | 3 | L>M | No | EVA | |
| rs471872367 | 5 | S>A | No | EVA | |
| rs453333997 | 8 | A>E | No | EVA | |
| rs433781613 | 11 | V>A | No | EVA | |
| rs433781613 | 11 | V>G | No | EVA | |
| rs472995604 | 12 | L>V | No | EVA | |
| rs436227102 | 13 | A>G | No | EVA | |
| rs454694824 | 13 | A>T | No | EVA | |
| rs456882788 | 14 | R>C | No | EVA | |
| rs431951539 | 14 | R>H | No | EVA | |
| rs431951539 | 14 | R>P | No | EVA | |
| rs465112170 | 15 | P>R | No | EVA | |
| rs480042154 | 16 | W>G | No | EVA | |
| rs467936248 | 16 | W>L | No | EVA | |
| rs449624174 | 18 | L>P | No | EVA | |
| rs449624174 | 18 | L>R | No | EVA | |
| rs438826978 | 19 | G>A | No | EVA | |
| rs463728600 | 19 | G>R | No | EVA | |
| rs438826978 | 19 | G>V | No | EVA | |
| rs459882991 | 20 | L>F | No | EVA | |
| rs441235370 | 20 | L>P | No | EVA | |
| rs441235370 | 20 | L>R | No | EVA | |
| rs454533174 | 21 | E>* | No | EVA | |
| rs442688572 | 21 | E>G | No | EVA | |
| rs454533174 | 21 | E>K | No | EVA | |
| rs454533174 | 21 | E>Q | No | EVA | |
| rs475794600 | 22 | G>A | No | EVA | |
| rs431983810 | 23 | C>G | No | EVA | |
| rs431983810 | 23 | C>R | No | EVA | |
| rs464906249 | 23 | C>S | No | EVA | |
| rs453038294 | 23 | C>W | No | EVA | |
| rs434437595 | 24 | G>V | No | EVA | |
| rs449458203 | 25 | V>A | No | EVA | |
| rs449458203 | 25 | V>D | No | EVA | |
| rs449458203 | 25 | V>G | No | EVA | |
| rs467975203 | 25 | V>L | No | EVA | |
| rs482470345 | 26 | P>A | No | EVA | |
| rs482470345 | 26 | P>T | No | EVA | |
| rs445474371 | 27 | R>G | No | EVA | |
| rs478266625 | 27 | R>I | No | EVA | |
| rs441272598 | 28 | R>L | No | EVA | |
| rs480483834 | 30 | A>G | No | EVA | |
| rs480483834 | 30 | A>V | No | EVA | |
| rs442627256 | 31 | Y>* | No | EVA | |
| rs462074152 | 31 | Y>D | No | EVA | |
| rs475583522 | 32 | E>A | No | EVA | |
| rs463698810 | 33 | W>G | No | EVA | |
| rs463698810 | 33 | W>R | No | EVA | |
| rs438649547 | 34 | G>V | No | EVA | |
| rs471423907 | 35 | V>G | No | EVA | |
| rs434474827 | 41 | P>R | No | EVA | |
| rs517656721 | 43 | P>L | No | EVA | |
| rs473932540 | 45 | P>R | No | EVA | |
| rs437426252 | 79 | D>H | No | EVA | |
| rs433427461 | 84 | H>P | No | EVA | |
| rs433427461 | 84 | H>R | No | EVA | |
| rs466014393 | 86 | K>N | No | EVA | |
| rs447639616 | 87 | F>V | No | EVA | |
| rs480420745 | 91 | P>A | No | EVA | |
| rs462112903 | 91 | P>L | No | EVA | |
| rs482081033 | 105 | Y>S | No | EVA | |
| rs463489718 | 108 | H>P | No | EVA | |
| rs438685952 | 110 | R>G | No | EVA | |
| rs471631479 | 114 | L>P | No | EVA | |
| rs442221872 | 126 | T>P | No | EVA | |
| rs383267114 | 165 | H>D | No | EVA | |
| rs452399409 | 182 | D>E | No | EVA | |
| rs431999177 | 234 | D>E | No | EVA | |
| rs457042423 | 234 | D>G | No | EVA | |
| rs211190276 | 277 | T>M | No | EVA | |
| rs482093706 | 283 | Y>D | No | EVA | |
| rs445158800 | 319 | G>V | No | EVA | |
| rs449379079 | 334 | K>E | No | EVA | |
| rs482423147 | 336 | L>V | No | EVA | |
| rs463685404 | 338 | Q>K | No | EVA | |
| rs444226172 | 362 | T>P | No | EVA | |
| rs470590828 | 364 | L>P | No | EVA | |
| rs1114810754 | 367 | E>K | No | EVA | |
| rs432190348 | 381 | L>V | No | EVA | |
| rs481759736 | 399 | E>K | No | EVA | |
| rs463228366 | 400 | P>A | No | EVA | |
| rs463228366 | 400 | P>S | No | EVA | |
| rs450951445 | 402 | G>R | No | EVA | |
| rs477362850 | 402 | G>V | No | EVA | |
| rs459065899 | 409 | E>G | No | EVA | |
| rs440447985 | 413 | K>N | No | EVA | |
| rs472439635 | 418 | Y>* | No | EVA | |
| rs438741794 | 419 | L>F | No | EVA | |
| rs460341950 | 419 | L>V | No | EVA |
No associated diseases with A4FUC0
No regional properties for A4FUC0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A4FUC0 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial large ribosomal subunit | The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALASGPARR | VLARPWGLGL | EGCGVPRRGA | YEWGVRSTRK | PEPPPLDRVY | EIPGLEPITF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGKMHFMPGL | ARPVFPPWDP | GWTHPKFRRL | PPLQEHPLYK | DEVCYIFHQR | CRLLEGVKQA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LWLTKTKLIE | GLPEKVLSLA | DNPRNHIENQ | DERVLNVISH | ARLWHSTEDI | PKRETYCPVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VDSLIQLCKS | QILKHPSLAR | RICAQKNMLS | TTWKRESTLI | QVHGSSGAQL | NAKDPLPPIA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SREEVEATKN | HVLETFSPIS | PTISLQECHI | YDVNDDTGFR | EGYPYPCPHT | LYLLESANLR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AHRFQPDQLR | AKMILFAFGN | ALAQARLLYG | NDPKVLEQPV | VVQSVGTDGR | VFQFLVLQLN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TTDLASEEGI | KNLVWVDSDQ | LLYQHFWCLP | VIKKKVVVEP | VGPTGFQPET | FRKFLALYLH |
| GAV |