AiPD: Autoinhibited Protein Database

A2RU30

Gene name	TESPA1 (KIAA0748, HSPC257)
Protein name	Protein TESPA1
Names	Thymocyte-expressed positive selection-associated protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9840
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

235-387 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

235-387 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for A2RU30

Entry ID	Method	Resolution	Chain	Position	Source
AF-A2RU30-F1	Predicted				AlphaFoldDB

456 variants for A2RU30

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1390408675 CA385155916	2	E>Q		No	ClinGen gnomAD
CA237503009 rs765306333	2	E>V		No	ClinGen Ensembl
rs113518906 CA385155890	3	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs113518906 CA6611494	3	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611492 rs529649457	5	V>M		No	ClinGen ExAC TOPMed gnomAD
rs866189777 CA237502979	7	S>I		No	ClinGen TOPMed
rs866189777 CA385155820	7	S>N		No	ClinGen TOPMed
rs1481915725 CA385155717	11	W>C		No	ClinGen gnomAD
rs1197251913 CA385155729	11	W>L		No	ClinGen TOPMed gnomAD
CA6611490 rs752877123	12	E>G		No	ClinGen ExAC TOPMed gnomAD
rs200900573 CA385155711	12	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA237502969 rs200900573	12	E>Q		No	ClinGen 1000Genomes TOPMed gnomAD
rs765811121 CA6611489	13	K>T		No	ClinGen ExAC TOPMed gnomAD
CA385155638 rs777006298	14	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6611487 rs777006298	14	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs760153858 CA6611488	14	R>W		No	ClinGen ExAC gnomAD
rs202144033 CA6611485	15	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs776869070 CA6611486	15	R>W		No	ClinGen ExAC TOPMed gnomAD
CA385155607 rs1592414357	17	W>G		No	ClinGen Ensembl
rs1393003375 CA385155588	18	L>F		No	ClinGen gnomAD
CA6611484 rs773870688	19	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6611483 rs62623446	19	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611482 rs748773318	20	Q>R		No	ClinGen ExAC gnomAD
rs201493678 CA6611481	21	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745812575 CA6611479 COSM1255611	22	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6611478 rs375755904	22	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA385155507 rs1179756295	23	N>K		No	ClinGen gnomAD
rs1442274453 CA385155474	24	W>*		No	ClinGen gnomAD
rs757003053 CA6611477	24	W>R		No	ClinGen ExAC TOPMed gnomAD
CA6611474 rs201481040 CA6611473	31	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385155329 rs778122709	31	E>G		No	ClinGen ExAC TOPMed gnomAD
CA237502825 rs973392036	31	E>K		No	ClinGen TOPMed
TCGA novel	31	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778122709 CA6611475	31	E>V		No	ClinGen ExAC TOPMed gnomAD
rs765431142 CA6611472	33	A>D		No	ClinGen ExAC gnomAD
rs866259394 CA237502767	34	A>S		No	ClinGen TOPMed
TCGA novel	34	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754305689 CA6611470	35	A>T		No	ClinGen ExAC gnomAD
CA385155251 rs1359487447 COSM941209	35	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs369460871 CA237502739	36	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs369460871 CA6611468	36	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs563892525 CA6611467	37	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6611465 rs762623373	39	D>G		No	ClinGen ExAC gnomAD
rs1385041581 CA385155169	39	D>Y		No	ClinGen gnomAD
CA385155139 rs1425467354	40	V>A		No	ClinGen gnomAD
CA6611464 rs774929485	40	V>I		No	ClinGen ExAC gnomAD
rs745747787 CA6611462	41	P>L		No	ClinGen ExAC TOPMed gnomAD
CA385155074 rs1455391162	44	E>D		No	ClinGen gnomAD
CA385155052 rs1364499907	47	S>C		No	ClinGen gnomAD
CA237502722 rs972300197	49	D>G		No	ClinGen Ensembl
CA6611461 rs770953624	50	D>E		No	ClinGen ExAC gnomAD
rs746752631 CA6611459	51	V>I		No	ClinGen ExAC gnomAD
CA6611457 rs758647001	52	F>C		No	ClinGen ExAC gnomAD
CA6611455 rs371973691	54	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611454 rs755007871	55	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6611427 rs201661060	56	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs573829374 CA6611426	58	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1181424097 CA385154737	62	E>A		No	ClinGen gnomAD
CA6611424 rs759266950	63	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1436021998 CA385154676	66	Q>H		No	ClinGen gnomAD
rs1274769108 CA385154669	67	D>H		No	ClinGen gnomAD
rs368284651	68	C>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs374220442 CA6611419	69	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6611420 rs773279415 CA6611421	69	G>R		No	ClinGen ExAC gnomAD
rs374220442 CA385154632	69	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs557305100 CA6611387	70	Y>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385153690 rs1262243069	72	E>K	Variant assessed as Somatic; 4.662e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1346431045 CA385153674	74	G>R		No	ClinGen TOPMed
CA385153669 rs1186098968	74	G>V		No	ClinGen TOPMed gnomAD
rs758788351 CA6611385	75	F>L		No	ClinGen ExAC gnomAD
CA385153666 rs1565856553	75	F>V		No	ClinGen Ensembl
CA237497029 rs1019447115	76	S>P		No	ClinGen Ensembl
TCGA novel	76	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385153646 rs1404788713	78	E>*		No	ClinGen gnomAD
CA6611383 rs568457749	79	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385153614 rs1261786612	82	F>L		No	ClinGen gnomAD
rs1008904616 CA237497012	84	Y>H		No	ClinGen gnomAD
CA385153595 rs1592377830	85	N>S		No	ClinGen Ensembl
CA6611369 rs773758607	86	G>V		No	ClinGen ExAC gnomAD
rs1463308663 CA385153568	87	F>L		No	ClinGen TOPMed gnomAD
rs772505149 CA6611368	87	F>L		No	ClinGen ExAC gnomAD
CA385153571 rs1296441335	87	F>S		No	ClinGen gnomAD
CA385153561 rs1354933203	88	C>*		No	ClinGen gnomAD
CA237496511 rs375638700	89	S>N		No	ClinGen ESP
CA6611367 rs748513459	89	S>R		No	ClinGen ExAC
CA385153539 rs1169419775	92	T>A		No	ClinGen gnomAD
CA385153534 rs1444258095	92	T>I		No	ClinGen TOPMed gnomAD
rs1383393582 CA385153527	93	S>R		No	ClinGen TOPMed gnomAD
rs779176792 CA6611366	94	F>L		No	ClinGen ExAC gnomAD
TCGA novel	95	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1359221146 CA385153509	96	D>N		No	ClinGen TOPMed
rs1176026741 CA385153490	98	L>F		No	ClinGen gnomAD
CA6611364 rs745527722	98	L>S		No	ClinGen ExAC TOPMed gnomAD
CA385153484 rs1481801018	99	T>S		No	ClinGen gnomAD
CA6611362 rs374110781	102	A>V	Variant assessed as Somatic; 4.653e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6611346 rs372384077	105	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6611344 rs200958597	109	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6611343 rs200958597	109	A>T	Variant assessed as Somatic; 0.0005579 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6611341 rs139412167	110	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611340 rs778891779	110	N>S		No	ClinGen ExAC gnomAD
CA6611342 rs139412167	110	N>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1176397379 CA385153410	111	G>S		No	ClinGen gnomAD
CA237495767 rs900647854	112	K>T		No	ClinGen Ensembl
rs1389521602 CA385153325	117	S>I		No	ClinGen TOPMed gnomAD
rs1389521602 CA385153327	117	S>T		No	ClinGen TOPMed gnomAD
rs61956830 CA6611329	120	E>K		No	ClinGen ExAC TOPMed gnomAD
CA237495482 rs61956830	120	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs770571350 CA6611328	121	T>S		No	ClinGen ExAC gnomAD
CA385153260 rs1300476232	123	R>K		No	ClinGen TOPMed
rs896462651 CA237495469	124	P>T		No	ClinGen Ensembl
rs1194934981 CA385153205	128	L>P		No	ClinGen gnomAD
TCGA novel	130	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385153180 rs1399074924	131	G>D		No	ClinGen TOPMed
rs1242013318 CA385153170	132	C>Y		No	ClinGen TOPMed gnomAD
CA385153136 rs1462602189	134	L>F		No	ClinGen TOPMed gnomAD
rs1201628953 CA385153139	134	L>S		No	ClinGen gnomAD
rs1279331623 CA385153132	135	A>S		No	ClinGen TOPMed gnomAD
rs1279331623 CA385153133	135	A>T		No	ClinGen TOPMed gnomAD
rs11543031 CA237495413	138	S>T		No	ClinGen Ensembl
rs760950444 CA237495408	139	M>T		No	ClinGen Ensembl
CA237495403 rs188445764	141	G>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs865817012 CA237495369	141	G>V		No	ClinGen Ensembl
CA237495384 rs188445764	141	G>W		No	ClinGen 1000Genomes TOPMed gnomAD
CA6611324 rs747716129	142	G>E		No	ClinGen ExAC TOPMed gnomAD
rs936076668 CA237495363	142	G>R		No	ClinGen TOPMed gnomAD
rs1365960762	143	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs535963986 CA6611322	147	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA385153001 rs1408934435	147	S>N		No	ClinGen gnomAD
rs1409375541 CA385152998	147	S>R		No	ClinGen TOPMed gnomAD
CA385152995 rs1335507783	148	S>P		No	ClinGen gnomAD
rs774765042 CA237495317	149	S>G		No	ClinGen Ensembl
rs919835074 CA237495309	149	S>N		No	ClinGen Ensembl
TCGA novel	154	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385152304 rs1264049854	154	L>V		No	ClinGen TOPMed
CA385152281 rs1445359556	156	K>N		No	ClinGen TOPMed
CA6611313 rs371203487	162	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA385152209 rs1157873320	162	E>V		No	ClinGen gnomAD
rs1172209527 CA385152193	163	D>E		No	ClinGen TOPMed
CA6611312 rs775943267	164	V>I		No	ClinGen ExAC gnomAD
rs765529486 CA6611311	165	L>F		No	ClinGen ExAC gnomAD
CA6611310 rs760014653	168	L>P		No	ClinGen ExAC TOPMed gnomAD
CA6611307 rs747628684	169	G>A		No	ClinGen ExAC gnomAD
CA6611308 rs771807845	169	G>C		No	ClinGen ExAC gnomAD
TCGA novel	172	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385152028 rs1349160945	178	T>A		No	ClinGen TOPMed gnomAD
CA237493563 rs1047717881	178	T>I		No	ClinGen Ensembl
CA385152027 rs1349160945	178	T>P		No	ClinGen TOPMed gnomAD
rs374279484 CA6611304	179	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA385152022 rs374279484	179	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	179	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6611303 rs749236193	180	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA237493554 rs767900906	180	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA385152014 rs376871530	181	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA237493482 rs961466251	181	I>T		No	ClinGen TOPMed
CA6611301 rs376871530	181	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6611298 rs757590911	183	A>S		No	ClinGen ExAC gnomAD
TCGA novel	183	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385151981 rs751647202	184	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM261553 rs751647202 CA6611297	184	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	186	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385151942 rs1420081992	187	T>I		No	ClinGen TOPMed
rs764285105 CA6611296	187	T>S		No	ClinGen ExAC gnomAD
CA237493394 rs911243864	188	T>I		No	ClinGen TOPMed
CA385151934 rs911243864	188	T>S		No	ClinGen TOPMed
rs758911223 CA385151927	189	P>H		No	ClinGen ExAC TOPMed gnomAD
rs758911223 CA385151926	189	P>L		No	ClinGen ExAC TOPMed gnomAD
rs758911223 CA6611295	189	P>R		No	ClinGen ExAC TOPMed gnomAD
rs753255610 CA6611294	192	A>G		No	ClinGen ExAC gnomAD
TCGA novel	193	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759798287 CA6611292	194	G>V		No	ClinGen ExAC gnomAD
CA385151845 rs1215145633	197	F>L		No	ClinGen gnomAD
rs777094131 CA6611291	199	L>V		No	ClinGen ExAC gnomAD
rs1323208662 CA385151752	204	Q>H		No	ClinGen gnomAD
rs1281782116 CA385151746	205	V>L		No	ClinGen gnomAD
rs773791963 CA385151733	206	R>L		No	ClinGen ExAC TOPMed gnomAD
rs773791963 CA6611288	206	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201890060 CA6611289 COSM431422	206	R>W	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA6611287 rs768157270	207	R>T		No	ClinGen ExAC gnomAD
rs1392944796 CA385151709	208	I>T		No	ClinGen TOPMed
TCGA novel	209	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385151662 rs748863415	212	D>A		No	ClinGen ExAC gnomAD
CA385151666 rs1428010839	212	D>H		No	ClinGen gnomAD
TCGA novel	212	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6611286 rs748863415	212	D>V		No	ClinGen ExAC gnomAD
CA237493330 rs200220468	215	L>F		No	ClinGen 1000Genomes TOPMed gnomAD
TCGA novel	215	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385151615 rs1178321895	215	L>R		No	ClinGen gnomAD
rs1364768303 CA385151612	216	M>V		No	ClinGen TOPMed gnomAD
TCGA novel	218	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1433620830 CA385151575	219	S>C		No	ClinGen gnomAD
CA385151577 rs1433620830	219	S>G		No	ClinGen gnomAD
CA6611271 rs751206071	219	S>R		No	ClinGen ExAC gnomAD
CA6611270 rs763793318	220	R>S		No	ClinGen ExAC TOPMed gnomAD
rs780852900 CA237492735	222	K>R		No	ClinGen Ensembl
CA6611269 rs762424349	223	Q>*		No	ClinGen ExAC gnomAD
rs1592353127 CA385151432	228	A>V		No	ClinGen Ensembl
CA237492725 rs1007008759	230	T>A		No	ClinGen TOPMed gnomAD
CA385151396 rs1251121115	232	D>Y		No	ClinGen gnomAD
CA385151370 rs1448289475	233	A>V		No	ClinGen TOPMed gnomAD
rs769575805 CA6611267	234	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	235	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385151284 rs1375155612	240	Y>*		No	ClinGen TOPMed
CA385151271 rs1356697105	242	S>P		No	ClinGen TOPMed gnomAD
CA385151233 rs1396556072	245	P>T		No	ClinGen gnomAD
rs1565843797 CA385151220	246	V>I		No	ClinGen Ensembl
rs1372266469 CA385151209	247	Q>*		No	ClinGen gnomAD
rs200661843 CA6611265	247	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs200661843 CA385151208	247	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs189241882 CA6611264	249	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385151175 rs778122771	251	P>A		No	ClinGen ExAC gnomAD
CA6611262 COSM225693 rs778122771	251	P>S	NS [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6611259 rs779074599	253	H>Y		No	ClinGen ExAC gnomAD
CA6611258 rs755383719	254	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1053510067 CA237492633	254	M>K		No	ClinGen Ensembl
TCGA novel CA385151133 rs1424907270	255	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
rs754372538 TCGA novel CA6611257	256	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
CA385151088 rs1555202437	258	C>Y		No	ClinGen Ensembl
CA6611256 rs371944624	259	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA385151071 rs371944624	259	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA385151059 rs1484271981	260	H>R		No	ClinGen gnomAD
rs368234850 CA6611255	262	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6611253 rs374059255	264	V>G		No	ClinGen ESP ExAC gnomAD
rs938614689 CA237492566	265	P>L		No	ClinGen TOPMed
rs987267738 CA237492561	266	S>P		No	ClinGen TOPMed gnomAD
CA6611251 rs762693782	267	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6611250 rs752097157	271	S>P		No	ClinGen ExAC gnomAD
CA6611248 rs759038034	272	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs759038034 CA6611249	272	R>G		No	ClinGen ExAC TOPMed gnomAD
rs371796001 CA6611247	272	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	273	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771045829 CA6611246	274	P>A		No	ClinGen ExAC TOPMed
CA385150910 rs771045829	274	P>S		No	ClinGen ExAC TOPMed
CA237492500 rs746661284	276	P>S		No	ClinGen Ensembl
TCGA novel	277	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773172848 CA6611244	278	S>L		No	ClinGen ExAC gnomAD
CA237492466 rs948501788	281	D>E		No	ClinGen gnomAD
rs1458528386 CA385150840	281	D>N		No	ClinGen gnomAD
TCGA novel	281	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs183884396 COSM1512712 CA6611243	282	R>C	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA6611242 rs748417344	282	R>H		No	ClinGen ExAC gnomAD
rs200509256 CA6611241	284	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs968269851 CA237492421	284	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6611238 rs61733027	286	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611237 rs151024475	287	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746187561 CA6611236	288	S>F		No	ClinGen ExAC
CA385150769 rs1258859557	288	S>T		No	ClinGen gnomAD
rs1329531278 CA385150721	291	C>Y		No	ClinGen gnomAD
rs1305560791 CA385150701	293	Y>H		No	ClinGen TOPMed
rs1221530399 CA385150682	294	T>I		No	ClinGen gnomAD
rs375940327 CA237492318	295	C>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA6611232 COSM549112 rs764857918	297	R>*	lung Variant assessed as Somatic; 4.646e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs371019313 COSM1362841 CA6611231	297	R>Q	large_intestine Variant assessed as Somatic; 4.649e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA237492283 rs570649963	298	D>E		No	ClinGen Ensembl
CA6611229 rs377625069	299	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753442863 CA6611230	299	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA237492241 rs1019783234	300	P>L		No	ClinGen Ensembl
CA237492230 rs1007020174	301	P>Q		No	ClinGen TOPMed gnomAD
rs773086602 CA6611227	302	P>S		No	ClinGen ExAC gnomAD
CA385150566 rs1400168626	303	P>A		No	ClinGen Ensembl
CA6611226 rs767350455	304	H>D		No	ClinGen ExAC gnomAD
rs761578612 CA6611225	305	N>K		No	ClinGen ExAC TOPMed gnomAD
CA6611224 rs774617369	306	T>N		No	ClinGen ExAC gnomAD
rs1387765935 CA385150477	307	P>L		No	ClinGen TOPMed gnomAD
CA385150486 rs1422220671	307	P>T		No	ClinGen TOPMed
rs1168327840 CA385150402	311	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6611223 rs768808903	311	S>I		No	ClinGen ExAC gnomAD
rs200394316 CA6611221	313	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	314	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6611219 rs746385862	320	M>I		No	ClinGen ExAC gnomAD
CA237492176 rs1044603555	321	D>G		No	ClinGen TOPMed gnomAD
CA385150203 rs1366536218	323	V>A		No	ClinGen gnomAD
rs757630791 CA6611217	324	K>E		No	ClinGen ExAC gnomAD
CA6611218 rs757630791	324	K>Q		No	ClinGen ExAC gnomAD
CA385150174 rs1413091427	326	E>Q		No	ClinGen gnomAD
CA6611215 rs1022146508	328	Q>*		No	ClinGen TOPMed
rs747384236 COSM1512411 CA6611214	328	Q>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1172751155 CA385150096	330	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1428710954 CA385150090	331	Q>*		No	ClinGen TOPMed gnomAD
CA385150085 rs61733026	331	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61733026 CA6611213	331	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611212 rs558058108	332	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
CA385150055 rs1280746897	333	D>V		No	ClinGen TOPMed
rs377169750 CA6611211	336	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1242423673 CA385149998	337	G>E		No	ClinGen gnomAD
CA385150008 rs1449596314	337	G>R		No	ClinGen gnomAD
CA385150004 rs1449596314	337	G>W		No	ClinGen gnomAD
CA385149994 rs1185375575	338	Q>*		No	ClinGen TOPMed gnomAD
rs1185375575 CA385149997	338	Q>K		No	ClinGen TOPMed gnomAD
CA385149957 rs1443885878	341	Q>E		No	ClinGen gnomAD
CA385149958 rs1443885878	341	Q>K		No	ClinGen gnomAD
CA385149952 rs766001045	341	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs766001045 CA6611210	341	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs756050901 CA6611209	344	P>R		No	ClinGen ExAC gnomAD
CA6611208 rs750383207	346	P>T		No	ClinGen ExAC gnomAD
TCGA novel	347	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs938626019 CA237492052	347	P>S		No	ClinGen gnomAD
rs1314911514 CA385149878	348	A>D		No	ClinGen TOPMed gnomAD
CA385149879 rs1314911514	348	A>G		No	ClinGen TOPMed gnomAD
rs761645482 CA6611206	350	G>D		No	ClinGen ExAC gnomAD
rs761645482 CA385149851	350	G>V		No	ClinGen ExAC gnomAD
COSM1255609 rs1565841727 CA385149835	352	K>T	oesophagus Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA6611205 rs774052805	353	L>F		No	ClinGen ExAC TOPMed gnomAD
CA385149805 rs1448168742	354	P>L		No	ClinGen TOPMed
rs764336520 CA385149811	354	P>S		No	ClinGen ExAC gnomAD
rs764336520 CA6611204	354	P>T		No	ClinGen ExAC gnomAD
TCGA novel	357	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385149781 rs1188403053	357	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6611203 rs201458525	358	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1170138650 CA385149776	358	Y>N		No	ClinGen gnomAD
CA6611202 rs775487994	361	V>I		No	ClinGen ExAC TOPMed gnomAD
CA385149726 rs1229942857	362	F>L		No	ClinGen TOPMed gnomAD
CA385149628 rs1319694853	368	T>I		No	ClinGen TOPMed
rs1308322723 CA385149613	370	Q>E		No	ClinGen TOPMed gnomAD
rs1303988192 CA385149601	371	R>K		No	ClinGen TOPMed
CA6611200 rs759672700	372	M>I		No	ClinGen ExAC
CA385149562 rs1238044114	374	T>A		No	ClinGen gnomAD
CA237491930 rs867978279	376	L>P		No	ClinGen TOPMed
rs1180800816 CA385149543	376	L>V		No	ClinGen gnomAD
rs1249847944 CA385149474	382	L>R		No	ClinGen gnomAD
COSM240361 CA237491916 rs912527619	384	S>L	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA385149441 rs1226970057	385	N>D		No	ClinGen gnomAD
rs747363248 CA385149438	385	N>I		No	ClinGen ExAC gnomAD
CA6611197 rs747363248	385	N>S		No	ClinGen ExAC gnomAD
CA6611196 rs201983343	386	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6611195 rs768297467	387	K>T		No	ClinGen ExAC TOPMed gnomAD
rs779921106 CA6611194	388	V>I		No	ClinGen ExAC gnomAD
rs779921106 CA6611193	388	V>L		No	ClinGen ExAC gnomAD
rs781152899 CA6611191	389	P>H		No	ClinGen ExAC TOPMed gnomAD
rs781152899 CA6611190	389	P>L		No	ClinGen ExAC TOPMed gnomAD
rs79969168 CA6611192	389	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757172821 CA6611189	392	T>A		No	ClinGen ExAC gnomAD
CA6611188 rs751316477	392	T>K		No	ClinGen ExAC gnomAD
TCGA novel	393	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	395	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1197146439 CA385149315	396	P>A		No	ClinGen TOPMed
rs752909410 CA6611185	397	I>T		No	ClinGen ExAC gnomAD
rs1376768610 CA385149305	397	I>V		No	ClinGen TOPMed
rs765494100 CA6611184	401	Q>*		No	ClinGen ExAC TOPMed
CA385149188 rs1413930877	402	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759584513 CA6611183	402	W>R		No	ClinGen ExAC gnomAD
rs267603555 CA237491837	403	S>N		No	ClinGen Ensembl
CA385149154 rs776608296	403	S>R		No	ClinGen ExAC gnomAD
rs369785136 CA6611181	404	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA385149133 rs1592348905	405	D>A		No	ClinGen Ensembl
CA6611180 rs761100208	405	D>E		No	ClinGen ExAC gnomAD
rs773560411 CA6611179	406	P>R		No	ClinGen ExAC gnomAD
CA385149083 rs1291170084	407	A>P		No	ClinGen TOPMed gnomAD
CA385149086 rs1291170084	407	A>T		No	ClinGen TOPMed gnomAD
CA6611177 rs748582552	407	A>V		No	ClinGen ExAC gnomAD
CA6611176 rs779828908	409	I>R		No	ClinGen ExAC gnomAD
rs779828908 CA385149038	409	I>T		No	ClinGen ExAC gnomAD
CA385149026 rs1290607684	410	R>K		No	ClinGen gnomAD
CA6611174 rs745329933	412	E>K		No	ClinGen ExAC TOPMed gnomAD
CA385148994 rs745329933	412	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1322614145 CA385148944	415	S>N		No	ClinGen TOPMed
rs757156026 CA6611172	415	S>R		No	ClinGen ExAC TOPMed gnomAD
rs751453945 CA6611171	417	P>R		No	ClinGen ExAC TOPMed gnomAD
CA237491749 rs191703973	420	N>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs148518799 CA6611169	421	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611170 rs148518799	421	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1480015993 CA385148821	423	T>I		No	ClinGen TOPMed gnomAD
rs1592348414 CA385148829	423	T>P		No	ClinGen Ensembl
rs1438691091 CA385148808	424	H>R		No	ClinGen TOPMed
CA385148818 rs1267105188	424	H>Y		No	ClinGen TOPMed
rs765407519 CA6611166	425	P>T		No	ClinGen ExAC TOPMed gnomAD
CA385148714 rs1164981021	429	E>D		No	ClinGen TOPMed
CA6611164 rs753897433	429	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766374435 CA6611163	430	T>N		No	ClinGen ExAC TOPMed gnomAD
CA237491721 rs961000518	431	F>S		No	ClinGen TOPMed
rs1312016313 CA385148584	436	S>N		No	ClinGen gnomAD
rs760876207 CA6611162	437	R>G		No	ClinGen ExAC gnomAD
CA6611161 rs773580545	437	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA385148524 rs1592347924	438	A>E		No	ClinGen Ensembl
CA237491673 rs954423101	441	S>G		No	ClinGen Ensembl
rs1252530121 CA385148429	441	S>N		No	ClinGen gnomAD
TCGA novel	444	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA237491662 rs1021822759	444	Q>R		No	ClinGen Ensembl
CA385148326 rs1367243323	446	N>I		No	ClinGen gnomAD
CA237491656 rs1012157162	446	N>K		No	ClinGen Ensembl
CA385148305 rs1321185573	447	L>F		No	ClinGen gnomAD
rs1565840046 CA385148269	449	G>D		No	ClinGen Ensembl
rs762235368 CA6611159	450	R>K		No	ClinGen ExAC gnomAD
TCGA novel	452	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774886174 CA6611158	452	V>L		No	ClinGen ExAC TOPMed gnomAD
CA237491627 rs752929437	453	K>N		No	ClinGen Ensembl
CA6611156 rs374552133	453	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA237491626 rs866328599	454	S>F		No	ClinGen Ensembl
rs776136486 CA6611155	455	L>S		No	ClinGen ExAC gnomAD
TCGA novel	457	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746585717 CA6611154	457	L>V		No	ClinGen ExAC gnomAD
rs1002565155 CA237491597	458	S>Y		No	ClinGen TOPMed gnomAD
CA6611151 rs201793282	459	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1592347393 CA385148109	460	T>P		No	ClinGen Ensembl
rs187244716 CA237491527	462	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
TCGA novel	464	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6611150 rs747893818	464	W>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA385148038 rs1211711670	464	W>R		No	ClinGen gnomAD
rs778697620 CA385147971	468	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6611149 rs778697620	468	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	469	D>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6611147 rs754003139	469	D>G		No	ClinGen ExAC gnomAD
rs1340535794 CA385147963	469	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1228122392 CA385147915	471	P>R		No	ClinGen gnomAD
CA237491496 rs536817892	471	P>T		No	ClinGen gnomAD
rs766683806 CA6611146	472	E>K		No	ClinGen ExAC TOPMed gnomAD
rs756127001 CA6611145	473	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6611144 rs533904016 COSM1211991	474	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6611143 rs370397366	474	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6611142 rs370397366	474	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385147866 rs61733025	475	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611141 rs61733025	475	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs887686132 CA237491430	475	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	476	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6611139 rs763438986	477	L>F		No	ClinGen ExAC gnomAD
rs1392123201 CA385147843	477	L>V		No	ClinGen gnomAD
CA237491371 rs929090294	478	S>N		No	ClinGen TOPMed gnomAD
CA6611138 rs776132703	479	Q>H		No	ClinGen ExAC gnomAD
CA237491366 rs919019422	481	P>L		No	ClinGen Ensembl
CA6611137 rs183029428	483	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	484	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA237491344 rs367594523	488	E>D		No	ClinGen ESP TOPMed
CA6611124 rs752104615	490	V>A		No	ClinGen ExAC
rs1179489121 CA385146500	493	N>H		No	ClinGen gnomAD
rs997173 CA385146435	496	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385146434 rs1186422189	496	E>G		No	ClinGen TOPMed
VAR_049513 CA6611122 rs997173	496	E>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA385146437 rs997173	496	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6611121 rs753139736	498	Q>*		No	ClinGen ExAC gnomAD
CA385146401 rs753139736	498	Q>E		No	ClinGen ExAC gnomAD
rs765902141 CA6611120	498	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA385146379 rs1365467267	499	S>T		No	ClinGen gnomAD
CA6611119 rs200382869	502	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6611118 rs772643563	502	R>H		No	ClinGen ExAC TOPMed gnomAD
CA385146274 rs1328154509	504	P>R		No	ClinGen gnomAD
CA6611116 rs137979349	505	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385146261 rs1464571672	505	S>N		No	ClinGen TOPMed
CA6611115 rs774253285	506	R>G		No	ClinGen ExAC TOPMed gnomAD
CA385146223 rs1308038103	507	P>L		No	ClinGen gnomAD
rs1308038103 CA385146225	507	P>R		No	ClinGen gnomAD
rs1365610984 CA385146212	508	R>K		No	ClinGen gnomAD
rs1437774628 CA385146196	509	H>Q		No	ClinGen TOPMed
CA385146189 rs1295743167	510	P>S		No	ClinGen gnomAD
CA6611112 rs114438533	511	H>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	512	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374408280 CA6611111	512	H>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs746087816 CA6611110	513	H>Y		No	ClinGen ExAC gnomAD
rs915076634 CA237490231	514	Q>*		No	ClinGen TOPMed
rs781628616 CA6611109	517	A>S		No	ClinGen ExAC TOPMed
TCGA novel	517	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	517	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385146039 rs1402787513	519	K>T		No	ClinGen TOPMed
TCGA novel	520	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757398136 CA6611107	520	D>N		No	ClinGen ExAC TOPMed
CA385146026 rs1459203489	520	D>V		No	ClinGen gnomAD
rs1363992382 CA385146007	521	S>L		No	ClinGen gnomAD

No associated diseases with A2RU30

No regional properties for A2RU30

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for A2RU30

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Endoplasmic reticulum membrane	May localize to mitochondria-associated endoplasmic reticulum membrane (MAM)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
COP9 signalosome	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
TCR signalosome	A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.

2 GO annotations of molecular function

Name	Definition
phospholipase binding	Binding to a phospholipase.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

6 GO annotations of biological process

Name	Definition
COP9 signalosome assembly	The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome.
positive regulation of T cell differentiation in thymus	Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
positive regulation of T cell receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
protein localization	Any process in which a protein is transported to, or maintained in, a specific location.
T cell differentiation in thymus	The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
TCR signalosome assembly	The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3U132	Tespa1	Protein TESPA1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEASVLSPTS	WEKRRAWLRQ	SRNWQTQVLE	EEAAAALQDV	PDPEPSSLDD	VFQEGNPINK
70	80	90	100	110	120
IEDWLQDCGY	SEEGFSEEAG	QFIYNGFCSH	GTSFEDDLTL	GAEATLLAAN	GKLFSRSFLE
130	140	150	160	170	180
TARPCQLLDL	GCSLASSSMT	GGTNKTSSSI	SEILDKVQED	AEDVLFSLGF	GQEDHKDTSR
190	200	210	220	230	240
IPARFFTTPS	QAKGIDFQLF	LKSQVRRIEM	EDPCLMLASR	FKQVQTLAVT	ADAFFCLYSY
250	260	270	280	290	300
VSKTPVQKFT	PSHMFWNCNH	PTDVPSIRIL	SREPEPQSPR	DRLRKAISKM	CLYTCPRDRP
310	320	330	340	350	360
PPPHNTPKRN	SLDQVVLEVM	DKVKEEKQFL	QQDSDLGQFS	QEDPVPPAEG	KKLPTSPYPC
370	380	390	400	410	420
VFCCEEETQQ	RMSTVLAPSQ	TLDSNPKVPC	CTHSLPIEDP	QWSTDPAQIR	RELCSLPATN
430	440	450	460	470	480
TETHPAKDET	FWKRKSRARK	SLFQKNLMGR	KVKSLDLSIT	QQKWKQSVDR	PELRRSLSQQ
490	500	510	520
PQDTFDLEEV	QSNSEEEQSQ	SRWPSRPRHP	HHHQTFAGKD	S