A2AIL4
Gene name |
Ndufaf6 |
Protein name |
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76947 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2AIL4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2AIL4-F1 | Predicted | AlphaFoldDB |
13 variants for A2AIL4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs266240142 | 5 | M>L | No | EVA | |
| rs3388673251 | 116 | F>S | No | EVA | |
| rs3388671958 | 123 | D>G | No | EVA | |
| rs27713797 | 171 | M>T | No | EVA | |
| rs3393936571 | 184 | S>T | No | EVA | |
| rs3388673212 | 194 | G>D | No | EVA | |
| rs3388667659 | 222 | Y>F | No | EVA | |
| rs3388676583 | 226 | R>T | No | EVA | |
| rs3388652736 | 228 | Q>R | No | EVA | |
| rs3388676555 | 253 | K>* | No | EVA | |
| rs3393994020 | 273 | A>* | No | EVA | |
| rs3388661950 | 323 | S>P | No | EVA | |
| rs3388676550 | 334 | Y>Y | No | EVA |
No associated diseases with A2AIL4
No regional properties for A2AIL4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A2AIL4 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| biosynthetic process | The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. |
| mitochondrial respiratory chain complex I assembly | The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| D3ZN43 | Ndufaf6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATSMLGSVR | GPRPFGLANL | FHRQPPRDAW | ERVRRLPGPS | AVRRSVAAAS | GPGIPGSHLY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CLELLRKRDY | ESYLCSLLFP | AECQRSASAL | RAFNVELAQV | KDSVSEKTIG | LMRMQFWKKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VEDMYCDNPP | HQPVAIELWK | AVKKHNLTKR | WLMRIIDERE | KNLDDKAYRS | MQELENYAEN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TQGSLLYLTL | EVLGVKDLHA | DHAASHIGKA | QGIVTCLRAT | PYHSSRRQVF | LPMDVCVQHG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VSQEDFLRRN | QDKNVRDVVY | DIASQAHLHL | KHARSFHRSV | PAEAFPAFLQ | TVSLEDYLKK |
| 310 | 320 | 330 | |||
| IQRVDFDIFH | PSLQQKNMLL | PLSLYIQSWR | KRY |