A2AB59
PR
Gene name |
Arhgap27 (Camgap1) |
Protein name |
Rho GTPase-activating protein 27 |
Names |
CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, Rho-type GTPase-activating protein 27 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:544817 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2AB59
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2AB59-F1 | Predicted | AlphaFoldDB |
47 variants for A2AB59
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389171138 | 8 | D>N | No | EVA | |
| rs3389171138 | 8 | D>Y | No | EVA | |
| rs3389201677 | 17 | F>L | No | EVA | |
| rs3389207793 | 19 | Y>S | No | EVA | |
| rs3389195907 | 30 | Q>H | No | EVA | |
| rs3389204919 | 48 | V>M | No | EVA | |
| rs3389209571 | 67 | L>V | No | EVA | |
| rs3402822636 | 74 | A>V | No | EVA | |
| rs224150691 | 81 | V>L | No | EVA | |
| rs3389209554 | 247 | R>Q | No | EVA | |
| rs3389195857 | 262 | R>H | No | EVA | |
| rs3389218857 | 270 | T>M | No | EVA | |
| rs3389206082 | 286 | T>I | No | EVA | |
| rs3389178517 | 309 | W>C | No | EVA | |
| rs3389223194 | 310 | D>E | No | EVA | |
| rs3389217010 | 324 | G>C | No | EVA | |
| rs3389209611 | 336 | E>K | No | EVA | |
| rs3389204895 | 361 | T>A | No | EVA | |
| rs3389195947 | 378 | Y>* | No | EVA | |
| rs3389182384 | 380 | P>S | No | EVA | |
| rs3389201648 | 381 | V>E | No | EVA | |
| rs253837882 | 387 | P>S | No | EVA | |
| rs3389211907 | 434 | N>S | No | EVA | |
| rs3389223212 | 450 | P>H | No | EVA | |
| rs229335160 | 452 | P>S | No | EVA | |
| rs3389195935 | 461 | D>G | No | EVA | |
| rs3389217028 | 474 | K>M | No | EVA | |
| rs3389204946 | 475 | I>F | No | EVA | |
| rs3389142499 | 477 | T>I | No | EVA | |
| rs3389209570 | 492 | K>E | No | EVA | |
| rs3389182371 | 524 | A>V | No | EVA | |
| rs3389204910 | 526 | G>S | No | EVA | |
| rs3389218848 | 609 | S>N | No | EVA | |
| rs3389208641 | 611 | D>N | No | EVA | |
| rs27021381 | 617 | R>C | No | EVA | |
| rs27021381 | 617 | R>S | No | EVA | |
| rs3389206115 | 627 | R>W | No | EVA | |
| rs3389178518 | 639 | G>D | No | EVA | |
| rs3389195858 | 644 | L>S | No | EVA | |
| rs3389171141 | 649 | H>R | No | EVA | |
| rs3389204983 | 715 | S>C | No | EVA | |
| rs3389142553 | 744 | V>A | No | EVA | |
| rs3389223252 | 757 | E>D | No | EVA | |
| rs3389195915 | 770 | Q>P | No | EVA | |
| rs3389208592 | 855 | V>M | No | EVA | |
| rs3389142498 | 858 | I>F | No | EVA | |
| rs261133564 | 864 | D>E | No | EVA |
No associated diseases with A2AB59
6 regional properties for A2AB59
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rho GTPase-activating protein domain | 677 - 866 | IPR000198 |
| domain | WW domain | 246 - 280 | IPR001202-1 |
| domain | WW domain | 299 - 333 | IPR001202-2 |
| domain | WW domain | 414 - 447 | IPR001202-3 |
| domain | SH3 domain | 6 - 69 | IPR001452 |
| domain | Pleckstrin homology domain | 477 - 595 | IPR001849 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| receptor-mediated endocytosis | An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12979 | ABR | Active breakpoint cluster region-related protein | Homo sapiens (Human) | PR |
| Q8IWW6 | ARHGAP12 | Rho GTPase-activating protein 12 | Homo sapiens (Human) | PR |
| Q6ZUM4 | ARHGAP27 | Rho GTPase-activating protein 27 | Homo sapiens (Human) | PR |
| Q5SSL4 | Abr | Active breakpoint cluster region-related protein | Mus musculus (Mouse) | PR |
| Q6TLK4 | Arhgap27 | Rho GTPase-activating protein 27 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAADVEGDVY | VLVEHPFEYT | GKDGRRIAIQ | PNERYRLLRR | STEHWWHVRR | EPGGRPFYLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQYVRELPAL | GDPAPAPQPS | VPQQRPAVPE | PLAYDYRFVS | TPVGADGSSA | EPRGRASSLC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GPARQRTGGQ | RNSLAPGGPA | CLYVRPAAPV | RPAQSLDDLA | RGGTAPPAGL | LGSAGHFKAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVAGSWVCPR | PLAPSDSENV | YEAIPDLRCP | PRAESPKQVD | DPPEPVYANV | ERQPRATSPR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SAAAPPRLSP | VWETHTDTGT | GRPYYYNPDT | GVTTWESPFE | TPEGTTSPAT | SRASVGSGES |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LETEWGQYWD | EESRRVFFYN | PLTGETAWED | ETEELEEDHQ | EQLEMQPSLS | PRSPGQQRPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TPETDYPELL | ASYPEEDYSP | VGSFSDPGPA | SPLVAPPGWS | CQITPDKQML | YTNQFTQEQW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VRLEDQHGKP | YFYNPEDSSV | QWELPQVPIP | APRSVRKSSQ | DSDTPAQASP | PEEKIKTLDK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AGVLHRTKTV | DKGKRLRKKH | WSTSWTVLEG | GVLTFFKDSK | TSAAGGLRQP | SKLSTPEYTV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELKGASLSWA | PKDKSSKKNV | LELRSRDGSE | YLIQHDSEAI | ISTWHKAIAE | GISELSADLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QGEEGEPSSA | DFGSSERLGS | WREEDVRQNA | ASPSLSPGGL | ESDLSRVRHK | LRKFLQRRPT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LQSLRDKGYI | KDQVFGCALA | QLCERERSPV | PRFVQQCIRT | VEARGLDIDG | LYRISGNLAT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IQKLRYKVDH | DERLDLDDGR | WEDVHVITGA | LKLFFRELPE | PLFPFSHFHQ | FIAAIKLQDP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AQRSRCVRDL | VRTLPAPNQD | TLRLLIQHLC | RVIEHGEQNR | MTVQNVAIVF | GPTLLRPEME |
| 850 | 860 | ||||
| EASMPMTMVF | QNQVVELILH | QCADIFPPH |