W5PND2

SS
Gene name
DDR1
Protein name
receptor protein-tyrosine kinase
Names
Species
Ovis aries (Sheep)
KEGG Pathway
mmu:12305
EC number
Protein Class

Descriptions

Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase with important functions in organogenesis and tissue homeostasis. The autoinhibition of DDR kinase activity is released by a two-step. First, phosphorylation of JM4 tyrosines likely ejects JM4 from the cleft between the kinase N- and C-lobes, resulting in a state of low activity that resembles the inactive kinase alone, with the A-loop still blocking the active site. In the second step, phosphorylation of the A-loop frees up the active site, resulting in a fully active kinase. Interestingly, the glycosylation at the Asn211 position could help to maintain the autoinhibitory state during the trafficking of the receptor to the cell surface by imposing steric or electrostatic effects that translate into downstream conformations.

Autoinhibitory domains (AIDs)

569-595 (Juxtamembrane 4 region) SS

Target domain

614-908 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for W5PND2

Entry ID Method Resolution Chain Position Source
AF-W5PND2-F1 Predicted AlphaFoldDB

21 variants for W5PND2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1092729259 20 A>T No Ensembl
rs408471111 22 M>V No Ensembl
rs1092224965 34 A>E No Ensembl
rs415808807 99 P>L No Ensembl
rs1094746247 100 G>V No Ensembl
rs1093869742 101 R>H No Ensembl
rs1092835531 103 R>G No Ensembl
rs1091071610 145 P>L No Ensembl
rs592363873 218 T>M No Ensembl
rs605506291 263 S>C No Ensembl
rs597224269 277 R>Q No Ensembl
rs591003488 342 R>H No Ensembl
rs603731954 345 R>H No Ensembl
rs604052155 370 V>L No Ensembl
rs590557710 379 G>S No Ensembl
rs1089392286 399 L>S No Ensembl
rs1090468552 494 R>H No Ensembl
rs1092674640 634 E>D No Ensembl
rs593566445 727 T>M No Ensembl
rs1086313802 758 R>C No Ensembl
rs1094840887 796 A>T No Ensembl

No associated diseases with W5PND2

6 regional properties for W5PND2

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 30 - 183 IPR000421
domain Protein kinase domain 614 - 908 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 614 - 908 IPR001245
conserved_site Tyrosine-protein kinase, receptor class II, conserved site 793 - 801 IPR002011
active_site Tyrosine-protein kinase, active site 765 - 777 IPR008266
domain Tyrosine-protein kinase, catalytic domain 614 - 908 IPR020635

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

1 GO annotations of biological process

Name Definition
collagen-activated tyrosine kinase receptor signaling pathway The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPGALSFLL LLLLVATGDA DMKGHFDPAK CRYALGMQDR TIPDGDISAS SSWSDSTAAR
70 80 90 100 110 120
HSRLESSDGD GAWCPAGPVF PKEEEYLQVD LRRLHLVAPG RPRHAGGLGK EFSPSYRLRY
130 140 150 160 170 180
SRDGHRWMDW RDRWGQEVIL GNEDPGGVVL KDLGPPMVAR LVRFYPRADR VMSVCLRVEL
190 200 210 220 230 240
YGCLWKDGLL SYTAPVGQTM YLSEAVHLND STYDGYTTHT VGGLQYGGLG QLADGVVGLD
250 260 270 280 290 300
DFRKSQELRV WPGYDYVGWS NHSFPSGYVE MEFEFDRLRA FQAMQVHCNN MHTLGARLPG
310 320 330 340 350 360
GVECRFKRGP AMAWEGEPVR HALGGSLGDP RARTVSVPLG GRMGRFLQCR FLFAGPWLLF
370 380 390 400 410 420
SEISFISDVV NDSSLALGGT FPPAPWWPPG PPPTNFSSLE LEPRGQQPVA KAEGSPTAIL
430 440 450 460 470 480
IGCLVAIILL LLLIIALMLW RRLHWRRLLS KDKAERRVLE EELTVHLSVP GDTILINNRP
490 500 510 520 530 540
GPREPPPYQE PRPRGNPPHS APGVPNSSAL LLSNPAYRLL LATYARPPRG PGPPTPAWAK
550 560 570 580 590 600
PTNTQACSGD YMEPEKPGAP LLPPPPQNSV PHYAEADIVT LQGVTGGNTY AVPALPPGAA
610 620 630 640 650 660
GDGPPRVDFP RSRLRFKEKL GEGQFGEVHL CEVESPQDLV SLDFPLNVRK GHPLLVAVKI
670 680 690 700 710 720
LRPDATKNAR NDFLKEVKIM SRLKDPNIIR LLGVCVQDDP LCMITDYMEN GDLNQFLSAH
730 740 750 760 770 780
QLEDKATEGA GDGEAAQGPT ISYPMLLHVA AQIASGMRYL ATLNFVHRDL ATRNCLVGEN
790 800 810 820 830 840
FTIKIADFGM SRNLYAGDYY RVQGRAVLPI RWMAWECILM GKFTTASDVW AFGVTLWEVL
850 860 870 880 890 900
MLCRAQPFGQ LTDEQVIENA GEFFRDQGRQ VYLSRPPACP LSLYDLMLRC WSREPEQRPP
910
FSQLHRFLAE DAVNTV