T2G6Z9

PR
Gene name
aprA
Protein name
Adenylylsulfate reductase subunit alpha
Names
AdoPSO(4) reductase subunit A, Adenosine 5'-phosphosulfate reductase subunit alpha, APSR subunit A
Species
Megalodesulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759) (Desulfovibrio gigas)
KEGG Pathway
dgg:DGI_0457
EC number
1.8.99.2: With other acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for T2G6Z9

Entry ID Method Resolution Chain Position Source
3GYX X-ray 320 A A/C/E/G/I/K 3-663 PDB
AF-T2G6Z9-F1 Predicted AlphaFoldDB

No variants for T2G6Z9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for T2G6Z9

No associated diseases with T2G6Z9

1 regional properties for T2G6Z9

Type Name Position InterPro Accession
domain FAD-dependent oxidoreductase 2, FAD binding domain 26 - 280 IPR003953

Functions

Description
EC Number 1.8.99.2 With other acceptors
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
adenylyl-sulfate reductase activity Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

2 GO annotations of biological process

Name Definition
dissimilatory sulfate reduction The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide.
protein heterotetramerization The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPKIPSKETP RGVAIAEPII VEHSVDLLMV GGGMGNCGAA FEAVRWADKY APEAKILLVD
70 80 90 100 110 120
KASLERSGAV AQGLSAINTY LGDNNADDYV RMVRTDLMGL VREDLIYDLG RHVDDSVHLF
130 140 150 160 170 180
EEWGLPVWIK DEHGHNLDGA QAKAAGKSLR NGDKPVRSGR WQIMINGESY KVIVAEAAKN
190 200 210 220 230 240
ALGQDRIIER IFIVKLLLDK NTPNRIAGAV GFNLRANEVH IFKANAMVVA CGGAVNVYRP
250 260 270 280 290 300
RSVGEGMGRA WYPVWNAGST YTMCAQVGAE MTMMENRFVP ARFKDGYGPV GAWFLLFKAK
310 320 330 340 350 360
ATNCKGEDYC ATNRAMLKPY EERGYAKGHV IPTCLRNHMM LREMREGRGP IYMDTKTALQ
370 380 390 400 410 420
TSFATMSPAQ QKHLEAEAWE DFLDMCVGQA NLWAATNCAP EERGSEIMPT EPYLLGSHSG
430 440 450 460 470 480
CCGIWASGPD EAWVPEDYKV RAANGKVYNR MTTVEGLWTC ADGVGASGHK FSSGSHAEGR
490 500 510 520 530 540
IVGKQMVRWY LDHKDFKPEF VETAEELKTL IYRPYYNYEK GKGASTCPVV NPEYISPKNF
550 560 570 580 590 600
MMRLIKCTDE YGGGVGTYYN TSKALLDTGF WLMEMLEEDS LKLAARDLHE LLRCWENYHR
610 620 630 640 650 660
LWTVRLHMQH IAFREESRYP GFYYRADFLG LDDSKWKCFV NSKYDPAKKE TKIFKKPYYQ
IIPTDA