Q9ZN49

PR
Gene name
dnaG
Protein name
DNA primase
Names
Species
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
KEGG Pathway
hpj:jhp_0010
EC number
2.7.7.101: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

384-469 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZN49

Entry ID Method Resolution Chain Position Source
AF-Q9ZN49-F1 Predicted AlphaFoldDB

No variants for Q9ZN49

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9ZN49

No associated diseases with Q9ZN49

6 regional properties for Q9ZN49

Type Name Position InterPro Accession
domain Zinc finger, CHC2-type 4 - 98 IPR002694
domain TOPRIM domain 246 - 327 IPR006171
domain DNA primase, DnaG 1 - 400 IPR006295
domain DNA primase, catalytic core, N-terminal 118 - 239 IPR013264
domain DNA primase DnaG, C-terminal helicase-binding domain 443 - 558 IPR031988
domain Bacterial DnaG primase, TOPRIM domain 246 - 324 IPR034151

Functions

Description
EC Number 2.7.7.101 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.
primosome complex Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA primase activity Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILKSSIDRL LQTIDIVEVI SSYVDLRKSG SNYMACCPFH EERSASFSVN QVKGFYYCFG
70 80 90 100 110 120
CGASGDSIKF VMAFEKLSFV EALEKLAHRF NIALEYDKGV YYDHKEDYHL LEMVSSLYQE
130 140 150 160 170 180
ELFNAPFFLN YLQKRGLSME SIKAFKLGLC TNKIDYGIEN KGLNKDKLIE LGVLGKSDKE
190 200 210 220 230 240
DKTYLRFLDR IMFPIYSPSA QVVGFGGRTL KEKAAKYINS PQNKLFDKSS LLYGYHLAKE
250 260 270 280 290 300
HIYKQKQVIV TEGYLDVILL HQAGFKNAIA TLGTALTPSH LPLLKKGDPE ILLSYDGDKA
310 320 330 340 350 360
GRNAAYKASL MLAKEQRKGG VILFENNLDP ADMIANHQIE TLKNWLSRPI AFIEFVLRHM
370 380 390 400 410 420
AGSYLLDDPL EKDKALKEML GFLKNFSLLL QNEYKPLIAT LLQAPLHVLG IREPVSFQPF
430 440 450 460 470 480
YPKTEKPNRP QKFAHVSSMP SLEFLEKLVI RYLLEDRSLL DLAVGYIHSG VFLHKKQEFD
490 500 510 520 530 540
ALCQEKLDDP KLVALLLDAN LPLKKGGFEK ELRLLILRYF ERQLKEIPKS PLSFSEKMIF
550
LKRARQAIMK LKQGELVAI