Q9ZKZ2
Gene name |
guaC |
Protein name |
GMP reductase |
Names |
Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase |
Species |
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) |
KEGG Pathway |
hpj:jhp_0790 |
EC number |
1.7.1.7: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ZKZ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ZKZ2-F1 | Predicted | AlphaFoldDB |
No variants for Q9ZKZ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9ZKZ2 | |||||
No associated diseases with Q9ZKZ2
5 regional properties for Q9ZKZ2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GMP synthase, C-terminal | 214 - 527 | IPR001674 |
| domain | GMP synthase, glutamine amidotransferase | 12 - 207 | IPR004739 |
| domain | Glutamine amidotransferase | 14 - 202 | IPR017926 |
| domain | NAD/GMP synthase | 216 - 256 | IPR022310 |
| domain | GMP synthetase ATP pyrophosphatase domain | 210 - 402 | IPR025777 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.7.1.7 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| GMP reductase complex | An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH(4)(+). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GMP reductase activity | Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| purine nucleotide metabolic process | The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKVFDYEDVQ | LIPNKCIVNS | RSECDTTVIL | GKHAFKMPIV | PANMQTIINE | SIAEFLAENG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YFYIMHRFNG | SARIPFVKKM | KERQLISSIS | VGVKKEECLF | VEELAKQGLT | PDYITIDIAH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GHSNSVIEMI | QRIKTRLPET | FVIAGNVGTP | EAVRELENAG | ADATKVGIGP | GKVCITKIKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFGTGGWQLA | ALRWCAKAAR | KPIIADGGIR | THGDIAKSIR | FGATMVMIGS | LFAGHEESSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETKIENGIAY | KEYFGSASEF | QKGEKKNIEG | KKIWIQHKGS | LKNTLIEMHQ | DLQSSISYAG |
| 310 | 320 | ||||
| GRDLEAIRKV | DYVIVKNSIF | NGDTI |