Q9ZJF9

PR
Gene name
dnaE (jhp_1353)
Protein name
DNA polymerase III subunit alpha
Names
Species
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
KEGG Pathway
hpj:jhp_1353
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

712-781 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZJF9

Entry ID Method Resolution Chain Position Source
AF-Q9ZJF9-F1 Predicted AlphaFoldDB

No variants for Q9ZJF9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9ZJF9

No associated diseases with Q9ZJF9

6 regional properties for Q9ZJF9

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 3 - 70 IPR003141
domain PHP domain 4 - 121 IPR004013
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 918 - 983 IPR004365
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 263 - 501 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 741 - 828 IPR029460
domain DNA polymerase III alpha subunit finger domain 504 - 667 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKENKAFTHL HLHTEYSLLD GANKIKILAK RIKELGMKSV SVTDHGNMFG AIDFYTSMKK
70 80 90 100 110 120
EGIKPIIGME AYIHNDDNLS SKETKQRFHL CLFAKNQEGY ENLMFLSSMA YLEGFYYFPR
130 140 150 160 170 180
INKKLLREHS KGIIASSACL QGEVNYHLNT NNERNRKYGA KGYDEAKRIA CEYQEIFEDD
190 200 210 220 230 240
FYLEIMRHGI LDQRFIDEQV IKMSLETGLK IIATNDTHYT MPNDAKAQEV AMCVAMGKTL
250 260 270 280 290 300
NDKGRLKHSV HEFYIKSPEE MAKLFADIPE ALENTQEIAD KCVLEIDLKD DKKNPPTPPS
310 320 330 340 350 360
FKFTKAYAQN EGLSFEDDAS YFAHKAREGL RERLILVPEE KHEQYKERLE KEIEVITNMK
370 380 390 400 410 420
FPGYMLIVWD FIRYAKEMGI PVGPGRGSAA GSLVAFALKI TDIDPLKYDL LFERFLNPER
430 440 450 460 470 480
VSMPDIDTDF CQRRRKEIIE YMIEKYGKYN VAQVITFNKM LAKGVIRDVA RVLDMPYKEA
490 500 510 520 530 540
DDFAKLIPNR LGITLKGYEK NGEFIEGAWE LEPKIKELVE SNEVAKQVWE YSLNLENLNR
550 560 570 580 590 600
NAGVHAAALV VDSQKELWHK TPLFASEKTG GIVTQYSMKY LEPVDLIKFD FLGLKTLTVI
610 620 630 640 650 660
DDALKIIKTQ HNIDVDFLSL DMDDPKVYKT IQSGDTVGIF QIESGMFQGL NKRLRPSSFE
670 680 690 700 710 720
DIIAIIALGR PGPMESGMVD DFVNRKHGVE PIAYAFKELE PILKPTYGTI VYQEQVMQIV
730 740 750 760 770 780
QTIGGFSLGE ADLIRRAMGK KDAQIMADNK AKFVEGAKNL GHDGQKAANL WDLIVKFAGY
790 800 810 820 830 840
GFNKSHSAAY AMITFQTAYL KTYYKHEFMA AMLTSESNKI ESVARYIDEV RALEIEVMPP
850 860 870 880 890 900
HINSSMQDFS VAEFKNQKGE LEKKIVFGLG AVKGVGGEPI KNIIEERAKG DYKSLEDFIS
910 920 930 940 950 960
RVDFSKLTKK SLEPLVKSGS LDNLGYTRKT MLANLDLICD AGRAKDKANE MMQGGNSLFG
970 980 990 1000 1010 1020
AMEGGIKEQV VLDMVDLGEH DAKTLLECEY ETLGIHVSGN PLDEFKEEIK GFKNLVKSID
1030 1040 1050 1060 1070 1080
IEELEIGSQA YLLGKIMEVK KKIGKRSGKP YGTADILDRY GKFELMLFEK QLNALEELDI
1090 1100 1110 1120 1130 1140
NKPLVFKCKI EEQEEVARLR LFEILDLESA REVKIPKARY KDPEKQKEDV REIPPMEMLA
1150 1160 1170 1180 1190 1200
SSSCSLAIVL ENDVKKEFLR QIKESALKHQ GKRPLYLIIK DKDKQFKIQS DLMVNEKIKD
1210
DFKGLEWRDL A