Q9ZHF6

PR
Gene name
polC
Protein name
DNA polymerase III PolC-type
Names
PolIII
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM0576
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

75-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9ZHF6

Entry ID Method Resolution Chain Position Source
2P1J X-ray 250 A A/B 347-522 PDB
AF-Q9ZHF6-F1 Predicted AlphaFoldDB

No variants for Q9ZHF6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9ZHF6

No associated diseases with Q9ZHF6

7 regional properties for Q9ZHF6

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 271 - 338 IPR003141
domain PHP domain 272 - 629 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 356 - 570 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 757 - 1025 IPR011708
domain Exonuclease, RNase T/DNA polymerase III 357 - 522 IPR013520
domain DNA polymerase, helix-hairpin-helix motif 1280 - 1358 IPR029460
domain DNA polymerase III alpha subunit finger domain 1029 - 1173 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKIENLKWK NVSFKSLEID PDAGVVLVSV EKFSEEIEDL VRLLEKKTRF RVIVNGVQKS
70 80 90 100 110 120
NGDLRGKILS LLNGNVPYIK DVVFEGNRLI LKVLGDFARD RIASKLRSTK KQLDELLPPG
130 140 150 160 170 180
TEIMLEVVEP PEDLLKKEVP QPEKREEPKG EELKIEDENH IFGQKPRKIV FTPSKIFEYN
190 200 210 220 230 240
KKTSVKGKIF KIEKIEGKRT VLLIYLTDGE DSLICKVFND VEKVEGKVSV GDVIVATGDL
250 260 270 280 290 300
LLENGEPTLY VKGITKLPEA KRMDKSPVKR VELHAHTKFS DQDAITDVNE YVKRAKEWGF
310 320 330 340 350 360
PAIALTDHGN VQAIPYFYDA AKEAGIKPIF GIEAYLVSDV EPVIRNLSDD STFGDATFVV
370 380 390 400 410 420
LDFETTGLDP QVDEIIEIGA VKIQGGQIVD EYHTLIKPSR EISRKSSEIT GITQEMLENK
430 440 450 460 470 480
RSIEEVLPEF LGFLEDSIIV AHNANFDYRF LRLWIKKVMG LDWERPYIDT LALAKSLLKL
490 500 510 520 530 540
RSYSLDSVVE KLGLGPFRHH RALDDARVTA QVFLRFVEMM KKIGITKLSE MEKLKDTIDY
550 560 570 580 590 600
TALKPFHCTI LVQNKKGLKN LYKLVSDSYI KYFYGVPRIL KSELIENREG LLVGSACISG
610 620 630 640 650 660
ELGRAALEGA SDSELEEIAK FYDYIEVMPL DVIAEDEEDL DRERLKEVYR KLYRIAKKLN
670 680 690 700 710 720
KFVVMTGDVH FLDPEDARGR AALLAPQGNR NFENQPALYL RTTEEMLEKA IEIFEDEEIA
730 740 750 760 770 780
REVVIENPNR IADMIEEVQP LEKKLHPPII ENADEIVRNL TMKRAYEIYG DPLPEIVQKR
790 800 810 820 830 840
VEKELNAIIN HGYAVLYLIA QELVQKSMSD GYVVGSRGSV GSSLVANLLG ITEVNPLPPH
850 860 870 880 890 900
YRCPECKYFE VVEDDRYGAG YDLPNKNCPR CGAPLRKDGH GIPFETFMGF EGDKVPDIDL
910 920 930 940 950 960
NFSGEYQERA HRFVEELFGK DHVYRAGTIN TIAERSAVGY VRSYEEKTGK KLRKAEMERL
970 980 990 1000 1010 1020
VSMITGVKRT TGQHPGGLMI IPKDKEVYDF TPIQYPANDR NAGVFTTHFA YETIHDDLVK
1030 1040 1050 1060 1070 1080
IDALGHDDPT FIKMLKDLTG IDPMTIPMDD PDTLAIFSSV KPLGVDPVEL ESDVGTYGIP
1090 1100 1110 1120 1130 1140
EFGTEFVRGM LVETRPKSFA ELVRISGLSH GTDVWLNNAR DWINLGYAKL SEVISCRDDI
1150 1160 1170 1180 1190 1200
MNFLIHKGME PSLAFKIMEN VRKGKGITEE MESEMRRLKV PEWFIESCKR IKYLFPKAHA
1210 1220 1230 1240 1250 1260
VAYVSMAFRI AYFKVHYPLQ FYAAYFTIKG DQFDPVLVLR GKEAIKRRLR ELKAMPAKDA
1270 1280 1290 1300 1310 1320
QKKNEVSVLE VALEMILRGF SFLPPDIFKS DAKKFLIEGN SLRIPFNKLP GLGDSVAESI
1330 1340 1350 1360
IRAREEKPFT SVEDLMKRTK VNKNHIELMK SLGVLGDLPE TEQFTLF