Q9ZDK2

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Rickettsia prowazekii (strain Madrid E)
KEGG Pathway
rpr:RP326
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

318-391 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZDK2

Entry ID Method Resolution Chain Position Source
AF-Q9ZDK2-F1 Predicted AlphaFoldDB

No variants for Q9ZDK2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9ZDK2

No associated diseases with Q9ZDK2

10 regional properties for Q9ZDK2

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 107 - 195 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 249 - 519 IPR003602
domain TOPRIM domain 1 - 116 IPR006171
domain DNA topoisomerase, type IA, central 75 - 88 IPR013497-1
domain DNA topoisomerase, type IA, central 131 - 567 IPR013497-2
domain DNA topoisomerase, type IA, zn finger 599 - 633 IPR013498
active_site DNA topoisomerase, type IA, active site 286 - 308 IPR023406
repeat Topoisomerase C-terminal repeat 661 - 713 IPR025589-1
repeat Topoisomerase C-terminal repeat 719 - 770 IPR025589-2
domain DNA topoisomerase 1, TOPRIM domain 1 - 128 IPR034149

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLVIVESPA KAKTINKYLG DEFKVIASFG HIRDLPSKKG SVLPDKNFLM EYDISDKAGK
70 80 90 100 110 120
YVDAIVKEAR KAEVVYLATD PDREGESISW HVAEVIKEKN KVESDDFFKR VAFNEITKKA
130 140 150 160 170 180
IMNAVANPRK LDTNLVNAQQ ARRALDYLVG FTLSPLLWRK LPGCKSAGRV QSVALRLICD
190 200 210 220 230 240
REDEIERFKS EEYWDISLKM QNSNNDLFTA KLTHVNDQKL KKFSIINEKE AKDLTQKLKL
250 260 270 280 290 300
QKFYVEKIEK KQQKRQPQPP FITSSLQQEA ARKLGFSAKK TMQIAQKLYE GVDIGKETIG
310 320 330 340 350 360
LITYMRTDGV TLSNDAIADI RKLIDKNYGN QYLPIKPRIY QSKVKNAQEA HEAIRPTNIT
370 380 390 400 410 420
YTPDSLKQKL EKDYYKLYEL IWHRTIACQM ENVIMDLVIA NLASENKEYL AKANGSIIAF
430 440 450 460 470 480
DGFYKVYRES LDDEDEEDNK MLPPLKEQEH IKTKEVIPNK HFTEPPPRYS EASLVKKLEE
490 500 510 520 530 540
LGIGRPSTYA SILSVLQDRK YVALEKKRFI PEELGRLVTV FLVGFFKKYV EYDFTAGLEN
550 560 570 580 590 600
ELDEIAAGKL EWKTALNNFW RGFNHNIESV NEQKITEIIN YLQKALDYHL FGEDKESKVC
610 620 630 640 650 660
PSCKTGQLSL KLGKFGAFLA CSNYPECTFK KSIVSGNDNN EDEGDPSTIL NDNKILGTDQ
670 680 690 700 710 720
DGVEIYLKKG PYGPYIQLGE QCGKVKPKRT PVPANLKQSE ITLEIALKLL NLPLKIGIHK
730 740 750 760 770
DSGEEIIIGY SKFGPYIKYM CKFISVPKKY DFLNLSLNDA MKLIQNNKAK LEKKYG