Q9ZCA4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Rickettsia prowazekii (strain Madrid E)
KEGG Pathway
rpr:RP856
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZCA4

Entry ID Method Resolution Chain Position Source
AF-Q9ZCA4-F1 Predicted AlphaFoldDB

No variants for Q9ZCA4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9ZCA4

No associated diseases with Q9ZCA4

2 regional properties for Q9ZCA4

Type Name Position InterPro Accession
domain Allantoicase domain 27 - 172 IPR015908-1
domain Allantoicase domain 191 - 333 IPR015908-2

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKFTTEEVR SKFITYFKAN NHTHVPASSL IPDNDPSLMF VNSGMVQFKN VFTGQEKRSY
70 80 90 100 110 120
NKAVTSQKSL RAGGKHNDLE HVGYTARHHT FFEMLGNFSF GDYFKEQAIY YTWDLLTKEF
130 140 150 160 170 180
ELPKDKLYVT IYHTDDPAAS YWKKIAGLKD DRIIRIKTND NFWSMGDTGP CGPCSEIFFD
190 200 210 220 230 240
HGEEIYGGLP GTKDENCDRF IEIWNMVFMQ YEQINKETRI ELPKKSIDTG MGLERMTAVL
250 260 270 280 290 300
QHVNNNYDID LFQEIINFTE NIVKIKVDGE AKFSYRVIAD HLRASSFLIA DGIIPSNEGR
310 320 330 340 350 360
GYVLRRIMRR AMRHAHMLGA KEPLMYKLLP KLVDLMGNIY PELKIAESFI SSILEQEEIR
370 380 390 400 410 420
FKTTLERGLK LLTEETKTLT KGSKLSGEVA FKLYDTYGFP LDLTEDILKN RDITVDHKGF
430 440 450 460 470 480
EELMLTQKER ARKSWLGSGE SKTDQLWFDI KEQYGSTEFL GYTLNEAECK IIALIKNNNL
490 500 510 520 530 540
VDNIQEINTQ FLLIANQTPF YGESGGQMGD IGMIFSQGSE IEVIDTFKYL RSIIVHKCIL
550 560 570 580 590 600
KKGKINIGEN ANLNINIRYR QNLRIHHSAT HILHAVLHKI LGKQVIQKGS LVTSTYLRFD
610 620 630 640 650 660
INHSKAITNQ EITLIEDQVN EIIRNNHEVT TTVMFTEDAI KQGAIALFGE KYDSEVRVVK
670 680 690 700 710 720
IGETSLELCC GTHVKRTGDI GSFKIISESA IAAGVRRIEA VCGEFVIKLI RERDSLLKSI
730 740 750 760 770 780
ESSFKTNKNE LITKVINILE RNKELEKELE KAHLASLDLS IEQIKKQTKE ITGIKLLYKE
790 800 810 820 830 840
VGNINNKILR QAAENLTKKV ENLIVVYIAH GVDKLSITVA VSKAITDKFN AGIIAKELSL
850 860 870
FLGGSGGGGQ ASIAQAGGND IINLTNINKK LWSLIVT