Q9Z774

PR
Gene name
lipA
Protein name
Lipoyl synthase
Names
Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA
Species
Chlamydia pneumoniae (Chlamydophila pneumoniae)
KEGG Pathway
cpt:CpB0861
EC number
2.8.1.8: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z774

Entry ID Method Resolution Chain Position Source
AF-Q9Z774-F1 Predicted AlphaFoldDB

No variants for Q9Z774

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Z774

No associated diseases with Q9Z774

2 regional properties for Q9Z774

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 68 - 276 IPR006638
domain Radical SAM 64 - 281 IPR007197

Functions

Description
EC Number 2.8.1.8 Sulfurtransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKCRPTLNTD QPRVRKKLPE RFPKWLQRPL PQGSAFHATD ATIKRSGMPT VCEEALCPNR
70 80 90 100 110 120
AECWSRKTAT YLALGDVCTR SCGFCNIGHS KTPPALDPTE PERIALSAKE LGLKHVVITM
130 140 150 160 170 180
VARDDLEDGG AQGLVDIIQK LREELPQATT EVLASDFQGN VSALHTLLDS GITIYNHNVE
190 200 210 220 230 240
TVARLSPLVR HKATYARSMF MLEQAANYLP DLKIKSGIMV GLGEMEGEVK QTLQDLASIG
250 260 270 280 290 300
VRIVTIGQYL RPSRKHLQVK SYVTPETFDY YRRVGEAMGL FVYAGPFVRS SFNADMILAS
VQDKASA