Q9Z2K0

PR
Gene name
Dedd (Deft)
Protein name
Death effector domain-containing protein
Names
Death effector domain-containing testicular molecule
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:83631
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z2K0

Entry ID Method Resolution Chain Position Source
AF-Q9Z2K0-F1 Predicted AlphaFoldDB

2 variants for Q9Z2K0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs197891341 213 N>T No EVA
rs198648683 237 K>E No EVA

No associated diseases with Q9Z2K0

1 regional properties for Q9Z2K0

Type Name Position InterPro Accession
domain Death effector domain 24 - 107 IPR001875

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli
  • Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

1 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

7 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
decidualization The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
extrinsic apoptotic signaling pathway via death domain receptors The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
negative regulation of protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.
negative regulation of transcription of nucleolar large rRNA by RNA polymerase I Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8WXF8 DEDD2 DNA-binding death effector domain-containing protein 2 Homo sapiens (Human) PR
O75618 DEDD Death effector domain-containing protein Homo sapiens (Human) PR
Q9Z1L3 Dedd Death effector domain-containing protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MAGLKRRASQ VWPEERVEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL
70 80 90 100 110 120
IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKKRRAVC PDLVDKYLEE
130 140 150 160 170 180
TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP VVCCPTSGSQ MCSKRPARGR TTLGSQRKRR
190 200 210 220 230 240
KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD
250 260 270 280 290 300
LGSIICDIKF SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED
310
YELGRQKLLR NLMLQALP