Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z2I3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2I3-F1 | Predicted | AlphaFoldDB |
No variants for Q9Z2I3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9Z2I3 | |||||
No associated diseases with Q9Z2I3
4 regional properties for Q9Z2I3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | TolB, N-terminal | 24 - 126 | IPR007195 |
| repeat | WD40-like beta propeller | 222 - 248 | IPR011659-1 |
| repeat | WD40-like beta propeller | 257 - 291 | IPR011659-2 |
| repeat | WD40-like beta propeller | 301 - 336 | IPR011659-3 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| C-C chemokine binding | Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| C-C chemokine receptor activity | Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of endothelial cell proliferation | Any process that activates or increases the rate or extent of endothelial cell proliferation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATYPEEAEL | ETEFPGTTFY | DYEFAQPCFK | VSITDLGAQF | LPSLFSLVFI | VGLLGNITVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VVLTKYQKLK | IMTNIYLLNL | AISDLLFLFT | LPFWTYYVHW | NKWVFGHFMC | KIISGLYYVG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFSEIFFIIL | LTIDRYLAIV | HAVFALRTRT | VTFGIITSVI | TWVLAVLAAL | PEFMFYGTQG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HFEVLFCGPS | YPEKKEHHWK | RFQALRMNIF | GLALPLLIMI | ICYTGIIKTL | LRCPSKKKYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AIRLIFVIMV | VFFVFWTPYN | LLLLFSAFDL | SFLDDCERSK | QLDMAKHVTE | VIAHTHCCIN |
| 310 | 320 | 330 | 340 | 350 | |
| PIIYAFVGER | FQKYLRHFLH | RNVTMHLSKY | IPFFTSEKLE | RSSSISPSSG | DPELSVVF |