Q9Z2D7

PR
Gene name
Mbd4
Protein name
Methyl-CpG-binding domain protein 4
Names
Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17193
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

292-386 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for Q9Z2D7

Entry ID Method Resolution Chain Position Source
1NGN X-ray 210 A A 400-554 PDB
3VXV X-ray 200 A A 69-136 PDB
3VXX X-ray 220 A A 69-136 PDB
3VYB X-ray 240 A A 69-136 PDB
3VYQ X-ray 252 A A/D 63-136 PDB
4EVV X-ray 239 A A 411-554 PDB
4EW0 X-ray 239 A A 411-554 PDB
4EW4 X-ray 279 A A 411-554 PDB
AF-Q9Z2D7-F1 Predicted AlphaFoldDB

No variants for Q9Z2D7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Z2D7

No associated diseases with Q9Z2D7

1 regional properties for Q9Z2D7

Type Name Position InterPro Accession
domain Methyl-CpG DNA binding 63 - 140 IPR001739

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nuclear, in discrete foci
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
pyrimidine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.

6 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
intrinsic apoptotic signaling pathway in response to DNA damage The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
mitotic G2 DNA damage checkpoint signaling A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
response to radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95983 MBD3 Methyl-CpG-binding domain protein 3 Homo sapiens (Human) PR
10 20 30 40 50 60
MESPNLGDNR VRGESLVPDP PWDRCKEDIA VGLGGVGEDG KDLVISSERS SLLQEPTAST
70 80 90 100 110 120
LSSTTATEGH KPVPCGWERV VKQRLSGKTA GKFDVYFISP QGLKFRSKRS LANYLLKNGE
130 140 150 160 170 180
TFLKPEDFNF TVLPKGSINP GYKHQSLAAL TSLQPNETDV SKQNLKTRSK WKTDVLPLPS
190 200 210 220 230 240
GTSESPESSG LSNSNSACLL LREHRDIQDV DSEKRRKSKR KVTVLKGTAS QKTKQKCRKS
250 260 270 280 290 300
LLESTQRNRK RASVVQKVGA DRELVPQESQ LNRTLCPADA CARETVGLAG EEKSPSPGLD
310 320 330 340 350 360
LCFIQVTSGT TNKFHSTEAA GEANREQTFL ESEEIRSKGD RKGEAHLHTG VLQDGSEMPS
370 380 390 400 410 420
CSQAKKHFTS ETFQEDSIPR TQVEKRKTSL YFSSKYNKEA LSPPRRKSFK KWTPPRSPFN
430 440 450 460 470 480
LVQEILFHDP WKLLIATIFL NRTSGKMAIP VLWEFLEKYP SAEVARAADW RDVSELLKPL
490 500 510 520 530 540
GLYDLRAKTI IKFSDEYLTK QWRYPIELHG IGKYGNDSYR IFCVNEWKQV HPEDHKLNKY
550
HDWLWENHEK LSLS