Q9Z286

PR
Gene name
Adcy10 (Sac)
Protein name
Adenylate cyclase type 10
Names
Germ cell soluble adenylyl cyclase, sAC, Testicular soluble adenylyl cyclase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:59320
EC number
4.6.1.1: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z286

Entry ID Method Resolution Chain Position Source
AF-Q9Z286-F1 Predicted AlphaFoldDB

No variants for Q9Z286

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Z286

No associated diseases with Q9Z286

3 regional properties for Q9Z286

Type Name Position InterPro Accession
ptm P-type ATPase, phosphorylation site 508 - 514 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 488 - 914 IPR044492
domain P5B-type ATPase, N-terminal 33 - 170 IPR047819

Functions

Description
EC Number 4.6.1.1 Phosphorus-oxygen lyases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm, cytoskeleton
  • Cytoplasm, perinuclear region
  • Nucleus
  • Cell projection, cilium
  • Cytoplasm
  • Mitochondrion
  • Distributed to subcellular compartments containing cAMP targets
  • Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

16 GO annotations of cellular component

Name Definition
apical part of cell The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
basal part of cell The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

6 GO annotations of molecular function

Name Definition
adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
bicarbonate binding Binding to bicarbonate ions (CHO3-).
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).

6 GO annotations of biological process

Name Definition
cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
cellular response to inorganic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
epithelial cilium movement involved in extracellular fluid movement The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSARRQELQD RAIVKIAAHL PDLIVYGDFS PERPSVKCFD GVLMFVDISG FTAMTEKFST
70 80 90 100 110 120
AMYMDRGAEQ LVEILNYYIS AIVEKVLIFG GDILKFAGDA LLALWKVERK QLKNIITVVI
130 140 150 160 170 180
KCSLEIHGLF EAKEVEEGLD IRVKIGLAAG HITMLVFGDE TRNYFLVIGQ AVDDVRLAQN
190 200 210 220 230 240
MAQMNDVILS PNCWQLCDRS MIEIERIPDQ RAVKVSFLKP PPTFNFDEFF AKCMAFMDYY
250 260 270 280 290 300
PSGDHKNFLR LACMLESDPE LELSLQKYVM EIILKQIDDK QLRGYLSELR PVTIVFVNLM
310 320 330 340 350 360
FKEQDKAEVI GSAIQAACVH ITSVLKVFRG QINKVFMFDK GCSFLCVFGF PGEKAPDEIT
370 380 390 400 410 420
HALESAVDIF DFCSQVHKIR TVSIGVASGI VFCGIVGHTV RHEYTVIGQK VNIAARMMMY
430 440 450 460 470 480
YPGIVTCDSV TYDGSNLPAY FFKELPKKVM KGVADPGPVY QCLGLNEKVM FGMAYLICNR
490 500 510 520 530 540
YEGYPLLGRV REIDYFMSTM KDFLMTNCSR VLMYEGLPGY GKSQVLMEIE YLASQHENHR
550 560 570 580 590 600
AVAIALTKIS FHQNFYTIQI LMANVLGLDT CKHYKERQTN LQNRVKTLLD DKYHCLLNDI
610 620 630 640 650 660
FHVQFPVSRE MSRMSKIRKQ KQLEALFMKI LEQTVREERI IFIIDEAQFV DVASWAFIEK
670 680 690 700 710 720
LIRSMPIFIV MSLCPFPETP CAAANAIMKN RNTTYITLGT MQPQEIRDKV CVDLSVSSIP
730 740 750 760 770 780
RELDSYLVEG SCGIPYYCEE LLKNLDHHRI LIFQQAEAEE KTNVTWNNLF KYSVKPTEDM
790 800 810 820 830 840
YLYTSIAAGQ KEACYLTSGV RLKNLSPPAS LKEISLVQLD SMSLSHQMLV RCAAIIGLTF
850 860 870 880 890 900
TTELLFEILP CWNMKMMIKA LATLVESNVF DCFRSSKDLQ LALKQNVTTF EVHYRSLSLK
910 920 930 940 950 960
SKEGLAYSEE EQLREMEGEV IECRILRFCR PIMQKTAYEL WLKDQKKVLH LKCARFLEES
970 980 990 1000 1010 1020
AHRCNHCRNR DFIPYHHFIA DIRLNTLDMD TVKKMVKSHG FKTEDEVIFS KSEIPRKFKF
1030 1040 1050 1060 1070 1080
PENISITETR EKILHFFDNV IIKMRTSQDD VIPLESCHCE ELLQIVILPL AQHFVALEEN
1090 1100 1110 1120 1130 1140
NKALYYFLEL ASAYLILGDN YNAYMYLGEG ERLLKSLTNE DSWSQTFEYA TFYSLKGEIC
1150 1160 1170 1180 1190 1200
FNMGQMVLAK KMLRKALKLL NRMFPCNLLS LTFQMHIEKN RLSHFMNQHT QEGSLPGKKL
1210 1220 1230 1240 1250 1260
AQLFLQSSCF SLLWKIYSLN FFFHYKYYGR LAAIMQMNTS LETQNNFQII KAFLDFSLYR
1270 1280 1290 1300 1310 1320
HLAGYEGVWF KYEILVMEQL LNLPLKGEAF EIMAYAADAL GHIKFLTGHL DLAIELGSRA
1330 1340 1350 1360 1370 1380
HKMWSLLRNP NKYHMVLCRL SKPLFLKSRY KHLVQVLGWL WDLSVTEEHI FSKAFFYFVC
1390 1400 1410 1420 1430 1440
LDIMLYSGFI YRTFEECLEF IHHNEDNRIL KFQSGLLLGL YSCIAVWYAR LQEWDNFYKF
1450 1460 1470 1480 1490 1500
SNRAKTLVTR RTPTVLYYEG ISRYMEGQVL HLQKQIEEQA ENAQDSGVEL LKALETLVAQ
1510 1520 1530 1540 1550 1560
NTTGPVFYPR LYHLMAYVCI LMGDGHSCDF FLNTALELSE TQGNLLEKCW LSMSKEWWYS
1570 1580 1590 1600
APELTGDQWL QTVLSLPSWD KIVSGNVTLQ DVQKNKFLMR VNILDNPF