Q9Z200
PR
Gene name |
Sh2b2 (Aps) |
Protein name |
SH2B adapter protein 2 |
Names |
Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:114203 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q9Z200
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1RPY | X-ray | 230 A | A/B | 401-510 | PDB |
| 1RQQ | X-ray | 260 A | C/D | 401-510 | PDB |
| 1YVH | X-ray | 205 A | B | 609-621 | PDB |
| AF-Q9Z200-F1 | Predicted | AlphaFoldDB |
2 variants for Q9Z200
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs106697348 | 336 | R>Q | No | EVA | |
| rs3322169990 | 519 | A>V | No | EVA |
No associated diseases with Q9Z200
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin filament | A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| SH2 domain binding | Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
| signaling adaptor activity | The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. |
| transmembrane receptor protein tyrosine kinase adaptor activity | The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| antigen receptor-mediated signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. |
| B cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. |
| B-1 B cell homeostasis | The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. |
| brown fat cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. |
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| insulin receptor signaling pathway | The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| regulation of immune response | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
| regulation of metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. |
| regulation of Ras protein signal transduction | Any process that modulates the frequency, rate or extent of Ras protein signal transduction. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9JID9 | Sh2b2 | SH2B adapter protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNGATPGSAA | APAPVPDWRQ | FCELHAQVAA | VDFAHKFCRF | LRDNPTYDTP | DAGTSFSRHF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AANFLAVFSE | EVRRVLGTAA | DTMEPEPAVT | SVTSALKTAT | YGHSRSSEDV | SAHVATKARV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKGFSLRNMS | LCVVDGVRDL | WHRRASPEPE | GGATPKTTEP | VSEPRDKWTR | RLRLARTLAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVELVDIQRE | GALRFMVADD | AASGPGGTAQ | WQKCRLLLRR | AVAGERFRLE | FFVPPKASRP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KVSIPLSAII | EVRTTMPLEM | PEKDNTFVLK | VENGAEYILE | TIDSLQKHSW | VADIQGCVDP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GDSEEDTGLS | CARGGCLASR | VTSCSCELLT | EADMPRPPET | MTAVGAVVTA | PHGRARDTVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ESLAHVPLET | FLQTLESSGG | VSESNNTGDE | GAELDPDAEA | ELELSDYPWF | HGTLSRVKAA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLVLAGGPRS | HGLFVIRQSE | TRPGECVLTF | NFQGKAKHLR | LSLNGHGQCH | VQHLWFQSVF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DMLRHFHTHP | IPLESGGSAD | ITLRSYVRAQ | GPPPDPGPAP | NTAAPVPACW | TEPAGQHYFS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SLATATCPPT | SPSNGAGASS | SSGSSSSATS | VPPRPAEGPL | SARSRSNSTE | HLLEAASGAT |
| 610 | 620 | ||||
| EEPADATLGR | ARAVENQYSF | Y |