Q9YI25
Gene name |
RPE65 |
Protein name |
Retinoid isomerohydrolase |
Names |
All-trans-retinyl-palmitate hydrolase, Lutein isomerase, Meso-zeaxanthin isomerase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase |
Species |
Ambystoma tigrinum (Eastern tiger salamander) |
KEGG Pathway |
|
EC number |
3.1.1.64: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9YI25
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9YI25-F1 | Predicted | AlphaFoldDB |
No variants for Q9YI25
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9YI25 | |||||
No associated diseases with Q9YI25
1 regional properties for Q9YI25
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ribosome control protein 1 | 734 - 986 | IPR009771 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.64 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity | Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid. |
| all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity | Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate. |
| cardiolipin binding | Binding to cardiolipin. |
| isomerase activity | Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. |
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
| phosphatidylcholine binding | Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
| phosphatidylserine binding | Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| retinoid metabolic process | The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
| zeaxanthin biosynthetic process | The chemical reactions and pathways resulting in the formation of zeaxanthin. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTNRVDHPAG | GYKKLFESTE | ELVAPVTAQV | TGRIPVWLSG | SLLRCGPGLF | EVGSEQFYHL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FDGQALLHKF | EFKGGHVIYH | RRFIRTDTYV | RAMTEKRIVI | TEFGTFAFPD | PCKNIFSRFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYFQGLEVTD | NALVNVYPVG | EDYYACTETN | YITKINPETL | ETVKKVDLCN | YVSINGVTAH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PHIEHDGTVY | NIGNCFGKHF | AFAYNIVKIP | PLQADKEDPI | NKAKVVVQFP | CSERFKPSYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HSFGLTPNYI | VFVEQPVKIN | LFKFLSSWSI | WGANYMDCFE | SHETMGVWMH | VAEKHTGEYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NIKYRTSAFN | LFHHINTYED | HGFLIVDLCC | WKGFEFVYNY | LYLANLRENW | EEVKRSAEKP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PQPEVRRYVL | PLDIHKVDTG | KNLVNLPYTT | ATAVLRSDET | IWLEPEVLFS | GPRQAFEFPQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| INYKKHGGKD | YTYAYGVGLN | HFVPDRLSKL | NVKTKETWVW | QEPDTYPSEP | IFVSQPDAIE |
| 490 | 500 | 510 | 520 | 530 | |
| EDDGVVLSVV | ISPGEGQKPA | FLLILNAKDM | SEIARAEVDS | NIPVTFHGMF | KKA |