Q9YEC5

PR
Gene name
ppsA (APE_0650.1)
Protein name
Phosphoenolpyruvate synthase
Names
PEP synthase, Pyruvate, water dikinase
Species
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
KEGG Pathway
ape:APE_0650.1
EC number
2.7.9.2: Phosphotransferases with paired acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

45-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9YEC5

Entry ID Method Resolution Chain Position Source
AF-Q9YEC5-F1 Predicted AlphaFoldDB

No variants for Q9YEC5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9YEC5

No associated diseases with Q9YEC5

5 regional properties for Q9YEC5

Type Name Position InterPro Accession
domain PEP-utilising enzyme, C-terminal 498 - 802 IPR000121
domain Pyruvate phosphate dikinase, AMP/ATP-binding 18 - 366 IPR002192
domain PEP-utilising enzyme, mobile domain 403 - 474 IPR008279
active_site PEP-utilising enzyme, active site 433 - 444 IPR018274
conserved_site PEP-utilising enzyme, conserved site 705 - 723 IPR023151

Functions

Description
EC Number 2.7.9.2 Phosphotransferases with paired acceptors
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
pyruvate, water dikinase activity Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate.

3 GO annotations of biological process

Name Definition
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERRLILWLD EISKDLLPLV GGKAAGLGEM IKAGIPVPPG FVVTSEAYRR FVFETGIAGF
70 80 90 100 110 120
IKHILEETIV SGRPEEYEKA SELIRSKFVR TPMPPYLRRA IVDAYRKLGT LVGVEEPRVA
130 140 150 160 170 180
VRSSATVEDL PEASFAGQQE TYLNVKGEEE VVEKVKTAWA SLWTARALSY RDSLNIDHET
190 200 210 220 230 240
ALMAVVVQKM VSSRSSGVMF TIHPVTGEED KIVIESIWGL GEYIVGGKVT PDRFVVSKSD
250 260 270 280 290 300
LEILEVRISR KDKALFYDPD LNENVEIKIP ESGEELEDLR RKHPAVAEVV EKYGIRPDAP
310 320 330 340 350 360
SLSEKEVKEL ARLAIKVENH FARPMDIEWA IDFELSPPEN ILLLQARPET VWSRKKEEAE
370 380 390 400 410 420
AKPPEEEAVP EGEVLVRGVP ASPGVASGRV KVALTVEEAA KKMEKGDVLV TKMTDPDWVP
430 440 450 460 470 480
YMKMASAIVT DEGGMTAHAA IVARELGIPA VVGTGDATKK LKDGMLVTVD GSRGVVYAGA
490 500 510 520 530 540
VKTEEAREEE ARPELGAAVA EVLSEVYPVT ATKIYMNLGH PEEIDRYKHL PFEGIGLMRI
550 560 570 580 590 600
EFIISSWIGY HPMYLIEQGR GVYFIDKLAE GVAKVASAIY PRPVVVRFSD FKTNEYRRLK
610 620 630 640 650 660
GGEKYETLDE RNPMIGWRGV SRYIHPNYEP AFRLEVRAIK KVREEWGLKN VWVMFPFVRT
670 680 690 700 710 720
TWELERALKI MEEEGLSRGR DFKVWIMVEV PSTVFLADEF AKMVDGFSIG SNDLTQLVLG
730 740 750 760 770 780
VDRDSGFLAK MGYFDERDPA VLRSIEILIE KAHSQGATVS ICGQGPSVYP ELVEFLVRRG
790 800 810
IDSISVNPDA VVRVRRQVAS IERRIMLERL EELGSRLSRL