Q9YC65
Gene name |
gdhA (APE_1386.1) |
Protein name |
Glutamate dehydrogenase |
Names |
GDH |
Species |
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) |
KEGG Pathway |
ape:APE_1386.1 |
EC number |
1.4.1.3: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9YC65
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9YC65-F1 | Predicted | AlphaFoldDB |
No variants for Q9YC65
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9YC65 | |||||
No associated diseases with Q9YC65
4 regional properties for Q9YC65
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal | 180 - 416 | IPR006096 |
| domain | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain | 34 - 161 | IPR006097 |
| active_site | Leu/Phe/Val dehydrogenases active site | 99 - 112 | IPR033524 |
| domain | NAD(P) binding domain of glutamate dehydrogenase | 180 - 410 | IPR033922 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.1.3 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutamate dehydrogenase (NAD+) activity | Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. |
| glutamate dehydrogenase (NADP+) activity | Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQPTDPLEEA | RAQLRRAVDL | LGYDDYVYEV | LANPDRVLQV | RVTIKMDDGT | VKTFLGWRSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HNSALGPYKG | GVRYHPNVTM | NEVIALSMWM | TWKNSLAGLP | YGGGKGGVRV | NPKILSPREL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELLSRKYFES | ISDIVGVDQD | IPAPDVYTDP | QVMSWFLDEY | NRVKRGQFFG | VVTGKPVELG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLNARIVSTG | YGVAVSTRVA | AEKFLGGLEG | RTVAVQGYGN | VGYYAAKFLA | EMGAKIVAVS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSRGGIYDPE | GIDPEEALKV | KRSTGTVANY | QRGKKISTME | ILELPVDILV | PAAIEEVITD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ENADRIKAKI | ISEGANGPTT | TAAEKILVKK | GVLVLPDILA | NAGGVIMSHI | EWVNNRMGGW |
| 370 | 380 | 390 | 400 | 410 | |
| ITDEEALKKL | EQKMVENTKT | VITYWEKNLK | PEENSLRDAA | YMIAVERVFR | AMKLRGWI |