Q9YAZ0

PR
Gene name
valS (APE_1805.1)
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
KEGG Pathway
ape:APE_1805.1
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9YAZ0

Entry ID Method Resolution Chain Position Source
AF-Q9YAZ0-F1 Predicted AlphaFoldDB

No variants for Q9YAZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9YAZ0

No associated diseases with Q9YAZ0

3 regional properties for Q9YAZ0

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 22 - 583 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 623 - 772 IPR013155
domain Valyl tRNA synthetase, anticodon-binding domain 583 - 718 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGEEFKPAIQ EKRWDIGEEE KLLSLWDAED LHKSTLDPDD PREIVVIDTP PPYPSGKWHV
70 80 90 100 110 120
GGAAHYTQID MIARYFRLKG YNVVAPFYAD RNGLPVEVQV EKTYGVVAHE MARTTEGRER
130 140 150 160 170 180
FLALCSEFLD KVESEIVQLW RRLGCGFDYW REGTDSPRYR SMTQATFIDL WRRGLIYEAE
190 200 210 220 230 240
RPVRWCPRCK TTLAEAEIEH KEDEDFIYYV KYRLEEDGRD LVVATTRPEL LAGCAALAYH
250 260 270 280 290 300
PEDERYKGLA GKTAIAPLYG HRVKIVEHPA VKKDFGTGLM MICSYGDEED VRLFLELDLK
310 320 330 340 350 360
PKVLIDENGV MNENAGPIAG LPVKEARRRI AEILEREGLL VKKERIVHSV PVCWRCKTPL
370 380 390 400 410 420
QIIHRRELFL RQLDFKDAVK QAAAKMDFKP EMHRKKLYDW IDSIKMDWPI SRERFYGTEI
430 440 450 460 470 480
PLWTCEKCGA KLVPEPGRYY RPWAEEPPWD SCPRCGAPRR YLKGETRVFD TWFDSSISPL
490 500 510 520 530 540
YVTRWMWDKR FYERASRNVL RPQGQDIIRT WLYYSILRVL QLTGKPAFRW VRITGLGLDP
550 560 570 580 590 600
KGRPMHKSLG NVIDPEPIIA KYGGDAFRFW AAIAAKLGYD YRFDENKVKT GRNFATKLWN
610 620 630 640 650 660
LARFVSSFPR PEGSPLEKAT EVDKAFLALA DEYLEAADKA YGELDVYEPA NLIYELAWDI
670 680 690 700 710 720
FASHYVELVK ERSYNRSGLF TREEQEAAWA TLHELLRRIL VALSPIMPFV TDAIHRRLYG
730 740 750 760 770 780
SSVHRQRWPD PLFTPEERRE LAGKARLIVS VNKAVWNLKR SMGKKLYEPL DTVEVLVPSG
790 800 810 820
IESARRDLEA LHKAAIRTYT GAPPEGSEEA IPGSSVYYIA KKS