Q9YA64

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
KEGG Pathway
ape:APE_2074.1
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

186-272 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9YA64

Entry ID Method Resolution Chain Position Source
2CYA X-ray 220 A A 1-364 PDB
AF-Q9YA64-F1 Predicted AlphaFoldDB

No variants for Q9YA64

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9YA64

No associated diseases with Q9YA64

3 regional properties for Q9YA64

Type Name Position InterPro Accession
domain Tubulin/FtsZ, GTPase domain 3 - 246 IPR003008
conserved_site Tubulin, conserved site 142 - 148 IPR017975
domain Tubulin/FtsZ, 2-layer sandwich domain 248 - 393 IPR018316

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVRVDVEERF NRIARNTVEI VTEEELKGLL ASGARIKGYI GYEPSGVAHI GWLVWMYKVK
70 80 90 100 110 120
DLVEAGVDFS VLEATWHAYI NDKLGGDMDL IRAAARIVRR VMEAAGVPVE RVRFVDAEEL
130 140 150 160 170 180
ASDKDYWGLV IRVAKRASLA RVRRALTIMG RRAEEAEVDA SKLIYPLMQV SDIFYMDLDI
190 200 210 220 230 240
ALGGMDQRKA HMLARDVAEK LGRKKPVAIH TPIISSLQGP GRMEASQGEI DDVLAEVKMS
250 260 270 280 290 300
KSKPETAVFV VDSDDDIRRK IRKAYCPAKQ VQGNPVLEIA RYILFARDGF TLRVDRPAKY
310 320 330 340 350 360
GGPVEYTSYE ELERDYTDGR LHPLDLKNAV AESLIEVVRP IRGAVLGDPA MKRALEAIEG
KVTR