Q9Y9X3

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
KEGG Pathway
ape:APE_2166
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

428-500 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Y9X3

Entry ID Method Resolution Chain Position Source
AF-Q9Y9X3-F1 Predicted AlphaFoldDB

No variants for Q9Y9X3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Y9X3

No associated diseases with Q9Y9X3

4 regional properties for Q9Y9X3

Type Name Position InterPro Accession
domain DHHA1 domain 737 - 875 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 656 - 699 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 556 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 712 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGFVRKEGAR CREAFWTLNP EFSEPQDTPC VEYWFDKVKS VSGMSVGEAR EAFLSFFEKH
70 80 90 100 110 120
GHTRVPPRPV VARWREDLYL TIASIVVFQP HVTSGLVPPP ANPLVISQPS IRLEDIDNVG
130 140 150 160 170 180
ITIGRHLTSF EMAAHHAFNY PDRQVYWKEE TVRLAFEFFT QVLGIPPELI VFKESWWEGG
190 200 210 220 230 240
GNAGPSFEVA VGGLELATLV FMKYRVVDGR YEEIPLKIVD TGYGVERLAW FTQKTPTAFH
250 260 270 280 290 300
AIYGSLVDDF RRMLGVEKPD ENVMWAAFRV AGFLDPEDPE SLRNYYQTVA SLAGGDVETV
310 320 330 340 350 360
RSILTREARL YSVLDHTKTI ALMLGDGIVP SNSGEGYLAR LVVRRALRQL SLLNAEVPLV
370 380 390 400 410 420
DLVERQARFW MRDFPQLKEN LDYILDAVSL EEERFRDVLR KARSIVEREL KRKKRLGVDD
430 440 450 460 470 480
LIRLYDSMGV PPEIAAEIAA SRGAPVEVPH NFYSLVAARH RGPEKIRGYG FDETGLPRDV
490 500 510 520 530 540
EEWARRFGET RRVFHEDPYA KAWKARVLGV KGRYLVADST IFYPTGGGQI HDTGVIRVNN
550 560 570 580 590 600
QQYRIIDVQK VGDAIVHVAE REIAAEPGDE VWMEIDWERR YSIMRHHTVT HVLIAAARRV
610 620 630 640 650 660
LGRHAWQAGA EKTEEKGRLD ITHHRPLTRD DIEKLENVVN QVIRERRRVW EDMVDKNEAE
670 680 690 700 710 720
EKYGFTIYQG GVPMEKRLRL VFVEDWDVEA CFGTHVRNTG EIGGFKIISY SRIQDGVVRL
730 740 750 760 770 780
EYVAGDRVAI YARELEERLA RIGDAVKAPR GQEEARVKGL IASLEQARED LKRYRDYWVK
790 800 810 820 830 840
TIEEAYISRA RRVNGVKVLA VESLEKDRRT VQEILRKLTS RHEDLIAALV VENEGNTQVE
850 860 870 880 890
IAAGPKAAEK VDLGALVKIV IKKVGGRGGG RGSYASLRVE GRLSADKVEE LLADALENVL