Q9Y7R4
Gene name |
set1 |
Protein name |
Histone-lysine N-methyltransferase, H3 lysine-4 specific |
Names |
COMPASS component set1, Lysine N-methyltransferase 2, SET domain-containing protein 1, Set1 complex component set1, Set1C component set1, Spset1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC306.04c |
EC number |
2.1.1.354: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Y7R4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Y7R4-F1 | Predicted | AlphaFoldDB |
No variants for Q9Y7R4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9Y7R4 | |||||
No associated diseases with Q9Y7R4
No regional properties for Q9Y7R4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9Y7R4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.354 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Set1C/COMPASS complex | A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone methyltransferase activity (H3-K4 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| heterochromatin assembly | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| histone H3-K4 methylation | The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFNTSTRSK | SQPVQRNNYK | VLYDPELGIK | ENLGRKIIYR | FNGVSKPPLV | VRDPRLKNPI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YARGIPKSGR | PFLKSLQTIN | YDYNENSLGP | EPPTQVFVSN | ISPLVTSEQL | RYHFKSFGEV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FDLDLKLNPY | TGTSLGLCCI | SFDKRSSISV | AAHSAKIAVQ | QANGLRFSGK | PLSVVLDRDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLCEEAFKKA | LNAVEKQFQE | ETLQKQRFER | EDESSRQKLS | AAMNEDIPPW | RQPSKNSQTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SNGDLQHSKV | QNVDQKSGFL | TSSETDVPKN | INDYIYLLID | DRFVPPDRVY | YTDIKHHFRK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FLYEKIYMNK | DGFYITFNNY | REASNCYRAL | DRTYVQNCRI | KLKFHDIPSR | TKEDGKKSAV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RRVVLPPEEA | YAEATSVVLR | DLEAALLRDV | KSKIIGPAIF | KYLHSMPKPS | VKEELQENLL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSSTSVPDVP | LKIESTVGKL | PSLPKFKKRV | DSSKMNLSAG | SKTKSKLQRR | RRRRHEARPL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HYQLNQMYNS | SASEAESDQE | LLLSSGDERV | ERGKIGSIKS | VKSDEATPVF | SDTSDENDKF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HRFRTKSKIS | KKKYEKMEVD | YTSSSETESD | ASILSPSAAI | PKSGSAIKDE | LISPKKEIDE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLALAPKWRI | NEFDETGSVY | YGALPYNYPE | DDVLLDLDGL | QYLVKNDEDY | SYLQEALKDE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PLMDINDPNF | WAYERKSCKF | KNGDVKYGDT | AILPEPKGYF | RSNTSGSAKS | EGYYIIPTTE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KSLYLPLRNR | STIDTISHST | SRITSRMNRV | NNRRLAAGVE | KSQLPAEADL | LRFNALKARK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KQLHFGPSRI | HTLGLFAMEN | IDKNDMVIEY | IGEIIRQRVA | DNREKNYVRE | GIGDSYLFRI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DEDVIVDATK | KGNIARFINH | SCAPNCIARI | IRVEGKRKIV | IYADRDIMHG | EELTYDYKFP |
| 910 | |||||
| EEADKIPCLC | GAPTCRGYLN |