Q9Y7J6

PR
Gene name
ppk21 (SPBC1778.10c, SPBC4C3.11)
Protein name
Serine/threonine-protein kinase ppk21
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

196-206 (Activation loop from InterPro)

Target domain

55-315 (Protein kinase domain)

Relief mechanism

Assay

218-226 (Activation loop from InterPro)

Target domain

55-315 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9Y7J6

Entry ID Method Resolution Chain Position Source
AF-Q9Y7J6-F1 Predicted AlphaFoldDB

No variants for Q9Y7J6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Y7J6

No associated diseases with Q9Y7J6

3 regional properties for Q9Y7J6

Type Name Position InterPro Accession
domain Protein kinase domain 55 - 315 IPR000719
active_site Serine/threonine-protein kinase, active site 175 - 187 IPR008271
binding_site Protein kinase, ATP binding site 61 - 93 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body
  • Located at the cell tips and septum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitotic spindle pole body The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
sphingolipid mediated signaling pathway The series of molecular signals mediated by a sphingolipid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMDLEHKRIS RSTLPDYADP DYFEARGERN PVKPQSSNVV PGTSHIGSIK SPADYVFGDI
70 80 90 100 110 120
IGDGSFSKVR RATDKKSWKE YAIKVLDKKY IVKENKVKYV NIERDSMMRL NGFPGISRLF
130 140 150 160 170 180
HTFQDDLKLY YVLELAPNGE LLQYIKKYRF LDENCVRFYA AEILSSIEYM HSCGIIHRDL
190 200 210 220 230 240
KPENILFDGN MHVKITDFGT AKILPPKYVN SPDYTTFPSS FVGTAEYVAP ELLSRQVVSK
250 260 270 280 290 300
SSDLWAFACV VYQMIVGSPP FHGSNPNNIF KKIMSLEYEL PKLLPPDIVP LFSHLFRIQP
310 320 330 340 350 360
SDRSTTQQIK QFPFFATITW DNLWTQDPPP MQSFRPNYNI AIPNAPAYYR SNVTAAAAAN
370 380 390 400 410 420
AAAAFASASI VKHQETARRQ ELPTVNRFTA PTAHYGYASL RSHQMPVDRL YYKLVPSSES
430 440 450 460 470 480
IIESTSVFVS PIPSVPEGNK FPSGLSKMFL KRKQRVMLLT DVGRCAFVCK GKHERLFIEM
490 500 510 520 530 540
EVNLKDSSVV VIFDENSSKR FLIEDKVQSW IIEDSSGDVT KYKDKILKFA DVASSHQSRS
550
SEENVEENEE E