Q9Y767
Gene name |
mip-1 (pol-g, NCU00276) |
Protein name |
DNA polymerase gamma, mitochondrial |
Names |
Mitochondrial DNA polymerase catalytic subunit |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU00276 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Y767
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Y767-F1 | Predicted | AlphaFoldDB |
No variants for Q9Y767
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9Y767 | |||||
No associated diseases with Q9Y767
4 regional properties for Q9Y767
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-directed DNA polymerase, family A, palm domain | 617 - 985 | IPR001098 |
| conserved_site | DNA-directed DNA polymerase, family A, conserved site | 792 - 811 | IPR019760 |
| domain | DNA mitochondrial polymerase, exonuclease domain | 113 - 392 | IPR041336 |
| domain | DNA polymerase gamma, palm domain | 631 - 1009 | IPR047580 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| gamma DNA polymerase complex | A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial DNA replication | The process in which new strands of DNA are synthesized in the mitochondrion. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTPVRCRTV | PNATVATAAR | VLRRANLFSR | YPRQLGHLRW | DSTIAQVLER | KGLGVPSTAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HNEIGVQQLS | EHLYKQLFPR | GNTDPPAPEL | IELAKDHLAR | HDLLGKTTDK | TPPIAFQLPA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVGDTLDEHF | HKLGVDAAEP | FLTHAKQFAD | AHLPPKPTSW | VRRSGWTKYN | RDGTTENDVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PQGNMMCFDV | EVMYKDNPYA | VMACAGTPDA | WYAWLSPWLL | GETENKAQLV | PMGDPTVDRI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVGHNIGYDR | AKILEEYDLK | QTRNFFLDTM | SLHVAVNGMC | SQQRPTWMKH | KKARELREKA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EHESASVELQ | EVLQGGSLTA | EEADLWVDKS | SINSLRDVAQ | FHLNVKIDKD | IRDVFAETDR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NVILNQLDDL | LTYCAADVQV | THQVYQVVFP | NFLGVCPHPV | SFAALRHLAS | VILPVNKTWD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TYIETAEATY | LQMLHGVQER | LFTLMERTLD | YKADPEKYLS | DPWLSQLDWS | GQEIKMAKPK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKGDVERPAL | NQKLPGYPQW | YKDLFVKVPK | ELSGLDEPDK | EQENRKARHE | FINLTVRSRI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| APLLLKLSWE | GYPLFWSDQF | GWTFQVPREK | AETFIQRQMT | PVQFEDPDVD | DRLRMDVDHK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YFKLPHKDGP | NARCVNPMAK | GYLPYFEKGI | LSSEYPYAKE | ALEMNASCSY | WISARERIKN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QMVVYEDQLP | PSQRFVNKDA | DSNTPIGGFV | LPQVIPMGTI | TRRAVERTWL | TASNAKKNRV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GSELKAMVRA | PPGYVFVGAD | VDSEELWIAS | VVGDATFKLH | GGNAIGFMTL | EGTKSQGTDL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HSRTASILGI | TRNDAKVFNY | GRIYGAGLKF | ASQLLRQFNP | SLTEAETTAI | ATKLYDATKG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AKTNRKSLYK | RPFWRGGTES | FVFNMLEEFA | EQERPRTPVL | GAGITEALMS | RWVSKGGFLT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SRINWAIQSS | GVDYLHLLII | AMDYLTRRFN | LACRLAITVH | DEIRYLAEEP | DKYRVAMALQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IANLWTRVMF | AQQVGIQDLP | QSCAFFSAVD | IDHVLRKEVD | MDCITPSNPI | PIAHGESIDI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FQILEKGDDA | KLDDSIVPQS | QYAPRLENIP | YTPRVPVMQR | LRERAEAGDH | QAFLRFIRAQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| ITNSDEELKR | IIAETRYSDP | YGAFSLASNG | RVSGNPHQRH | AAVHASTKTA | AAPSKPSIAS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RFDSVSQASR | IKSVAAGSDE | PTIRATKAQG | KAMAKASGTK | LAASTKDTVL | NVTIKKKVAA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PEMAAVPSTS | SESKSKASAT | TSTTTTENAT | ASPSSSSNVD | AKKTTSKTKP | THKKETEGEP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| FPSLDDPVIA | ARLEAVSKTS | PGTRASVAAK | LDALASFSMR | AAAAAEAAVT | TTTTPEPPTN |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| PPPVAPKAKE | PTTTMAEKVL | KPTAVPKNPT | PTLTPTTKKS | NPTSTPTTPK | PVGRPRTTPI |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LPYTAPKKKL | PSSAFSKEQK | EPMSVSEAVW | TASVGGRATT | TTATATATGD | EKKKTTTTPS |
| 1450 | |||||
| WKPVKESLFG | RGVYIP |