Q9Y738

PR
Gene name
mis12 (SPBC409.04c)
Protein name
Centromere protein mis12
Names
NMS complex subunit mis12
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC409.04c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9Y738

Entry ID Method Resolution Chain Position Source
5WWL X-ray 240 A M 1-215 PDB
AF-Q9Y738-F1 Predicted AlphaFoldDB

No variants for Q9Y738

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Y738

No associated diseases with Q9Y738

5 regional properties for Q9Y738

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 213 - 525 IPR001674
domain GMP synthase, glutamine amidotransferase 10 - 205 IPR004739
domain Glutamine amidotransferase 12 - 200 IPR017926
domain NAD/GMP synthase 223 - 295 IPR022310
domain GMP synthetase ATP pyrophosphatase domain 208 - 400 IPR025777

Functions

Description
EC Number
Subcellular Localization
  • Chromosome, centromere
  • Chromosome, centromere, kinetochore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
chromosome, centromeric core domain The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it.
condensed chromosome, centromeric region The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
inner kinetochore The region of a kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
NMS complex A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes.
nuclear MIS12/MIND complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
kinetochore assembly The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
mitotic sister chromatid segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
monopolar spindle attachment to meiosis I kinetochore The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLVELLEFTP LSFIDDVINI TNQLLYKGVN GVDKAFSQTR FAKKAPQEIE EGLHKFEVLF
70 80 90 100 110 120
ESVVDRYYDG FEVYTLRNIF SYPPELKGYM RTFGKDVDYS ITTEQDAAMD QAIQEAAEKL
130 140 150 160 170 180
VVKMQLRRDL RMRLSRKREK KTEIEKHLER ISFLNKVPEN WQVTLPETTD FLLDQLGNLQ
190 200 210 220 230 240
HAVKRVVEAS PTVHSREVDE RITYLEKGYE RLSNPIDQQK DFWSHHLSKL ESTANTETAN
250
NIHKLLLSSE KDVGHTDEP