AiPD: Autoinhibited Protein Database

Q9Y6I9

Gene name	TEX264
Protein name	Testis-expressed protein 264
Names	Putative secreted protein Zsig11
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51368
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

202-282 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

202-282 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9Y6I9

Entry ID	Method	Resolution	Chain	Position	Source
7VEC	X-ray	300 A	M/N/O/P/Q/R/S/T/U/V/X	271-278	PDB
7VED	X-ray	202 A	A/B	271-281	PDB
AF-Q9Y6I9-F1	Predicted				AlphaFoldDB

261 variants for Q9Y6I9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM3427729 rs371048238 CA74707448	2	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2424616 rs371048238	2	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1577488848 CA353039376	3	D>A		No	ClinGen Ensembl
rs1429628228 CA353039375	3	D>Y		No	ClinGen gnomAD
CA353039390 rs1487622497	5	L>R		No	ClinGen TOPMed
rs1302055289 CA353039396	7	L>V		No	ClinGen gnomAD
rs1286823097 CA353039406	8	G>D		No	ClinGen gnomAD
CA2424621 rs147968046	10	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1216619529 CA353039419	11	G>R		No	ClinGen TOPMed
CA353039426 rs1215494141	12	G>S		No	ClinGen gnomAD
rs1559668735 CA353039435	14	T>P		No	ClinGen Ensembl
rs141543510 CA74707557	15	L>F		No	ClinGen ESP TOPMed
rs1577489019 CA353039451	16	L>F		No	ClinGen Ensembl
rs1399195733 CA353039464	19	L>V		No	ClinGen TOPMed
CA2424623 rs375351243	20	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA353039497 rs1466054590	25	A>T		No	ClinGen TOPMed
CA2424627 rs368266955	26	G>A		No	ClinGen ESP ExAC gnomAD
CA353039505 rs368266955	26	G>E		No	ClinGen ESP ExAC gnomAD
rs751516569 CA2424626	26	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353039509 rs1577489135	27	Y>D		No	ClinGen Ensembl
CA2424630 rs151059647	30	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs200626698 CA353039551	34	V>E		No	ClinGen ExAC TOPMed gnomAD
CA2424631 rs200626698	34	V>G		No	ClinGen ExAC TOPMed gnomAD
rs769193290 CA2424633	35	E>D		No	ClinGen ExAC gnomAD
rs749586556 CA2424632	35	E>G		No	ClinGen ExAC gnomAD
rs770504011 CA353039561	36	V>A		No	ClinGen ExAC TOPMed
rs770504011 CA2424636	36	V>G		No	ClinGen ExAC TOPMed
rs779513874 CA2424635	36	V>L		No	ClinGen ExAC
rs779513874 CA2424634	36	V>M		No	ClinGen ExAC
rs1328811463 CA353039570	38	A>T		No	ClinGen gnomAD
rs1577489286 CA353039584	40	S>A		No	ClinGen Ensembl
rs199677902 CA353039589	41	P>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	41	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353039591 rs1228237936	41	P>R		No	ClinGen gnomAD
CA2424638 rs199677902	41	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1266614723 CA353039594	42	P>A		No	ClinGen gnomAD
rs963054402 CA74707746	44	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs570400367 CA2424641	44	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353039609 rs570400367	44	R>L		No	ClinGen ExAC TOPMed gnomAD
rs74561651 CA2424642	45	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1233425655 CA353039617	46	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2424644 rs761751528	47	T>I		No	ClinGen ExAC gnomAD
CA74707801 rs796554980	49	A>T		No	ClinGen TOPMed
rs1461640829 CA353039642	50	Y>S		No	ClinGen gnomAD
CA2424647 rs756259318	52	F>L		No	ClinGen ExAC gnomAD
CA2424648 rs766489140	53	H>Y		No	ClinGen ExAC gnomAD
rs755357788 CA2424650	54	M>T		No	ClinGen ExAC TOPMed
CA2424649 rs754113085	54	M>V		No	ClinGen ExAC gnomAD
rs1271935148 CA353039678	55	G>E		No	ClinGen gnomAD
CA2424651 rs779429677	55	G>R		No	ClinGen ExAC gnomAD
CA2424652 rs748610886	57	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA353039696 rs1577489518	58	G>C		No	ClinGen Ensembl
rs778381727 CA2424654	62	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2424653 rs201059799	62	R>W	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1234156170 CA353039725	63	L>F		No	ClinGen gnomAD
CA353039742 rs1265132441	65	T>I		No	ClinGen gnomAD
rs745345314 CA2424656	66	E>D		No	ClinGen ExAC gnomAD
CA2424657 rs751449965	67	S>N		No	ClinGen ExAC TOPMed gnomAD
CA2424658 rs751449965	67	S>T		No	ClinGen ExAC TOPMed gnomAD
CA2424659 rs768382094	68	C>G		No	ClinGen ExAC TOPMed gnomAD
rs768382094 CA353039757	68	C>R		No	ClinGen ExAC TOPMed gnomAD
rs774118333 CA2424660	69	S>G		No	ClinGen ExAC gnomAD
rs138563355 CA2424663	73	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs760622582 CA2424664	75	R>C		No	ClinGen ExAC TOPMed gnomAD
rs371669346 CA2424665	75	R>H		No	ClinGen ExAC TOPMed gnomAD
CA74708014 rs371669346	75	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1375006668 CA353039812	77	I>V		No	ClinGen gnomAD
CA353039819 rs780205946	78	A>S		No	ClinGen ExAC gnomAD
CA2424668 rs780205946	78	A>T	Variant assessed as Somatic; 9.246e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	79	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758880076 CA2424670	80	Y>C		No	ClinGen ExAC gnomAD
CA353039840 rs1178987730	81	Y>C		No	ClinGen TOPMed
rs778091014 CA2424671	83	N>S		No	ClinGen ExAC TOPMed gnomAD
rs747579083 CA2424672	84	P>L		No	ClinGen ExAC gnomAD
CA353039859 rs1237735013	84	P>T		No	ClinGen TOPMed
CA2424673 rs755508970	85	H>D		No	ClinGen ExAC gnomAD
rs555508141 CA353039874	86	M>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs555508141 CA2424674	86	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353039872 rs1338982079	86	M>V		No	ClinGen gnomAD
CA74679084 rs946966866	89	P>A		No	ClinGen TOPMed gnomAD
rs1305707677 CA353041383	91	K>Q		No	ClinGen gnomAD
CA353041418 rs1348523007	93	R>*		No	ClinGen gnomAD
CA353041421 rs1232360133	93	R>Q		No	ClinGen TOPMed gnomAD
rs558942440 CA74679092	94	C>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs764520358 CA2424689	95	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1205479953 CA353041444	95	A>V		No	ClinGen gnomAD
COSM1424290 rs1463264821 CA353041447	96	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA353041472 rs1195017853	98	S>N		No	ClinGen gnomAD
rs757769424 CA2424691	99	I>L		No	ClinGen ExAC
rs886519784 CA74679138	103	G>D		No	ClinGen Ensembl
CA2424692 rs781613518	103	G>R		No	ClinGen ExAC
CA353041560 COSM1485354 rs1395096275	104	E>D	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs753312901 CA2424693	106	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1259497973 CA353041614	108	S>C		No	ClinGen gnomAD
CA353041654 rs1455714535	112	I>V		No	ClinGen gnomAD
CA74679174 rs1056595614	113	D>G		No	ClinGen TOPMed
CA2424696 rs747830496	113	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1312021674 CA353041717	116	Q>R		No	ClinGen TOPMed
CA353041741 rs1328011009	118	F>L		No	ClinGen gnomAD
rs1448212281 CA353041758	121	K>E		No	ClinGen TOPMed
CA74679179 rs895196115	121	K>N		No	ClinGen TOPMed
CA2424698 rs372279086	122	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1056666177 CA74679196	123	F>I		No	ClinGen TOPMed gnomAD
CA74679221 rs896404201	124	S>P		No	ClinGen TOPMed gnomAD
rs1559675123 CA353041782	125	F>L		No	ClinGen Ensembl
rs1267244615 CA353041786	125	F>L		No	ClinGen gnomAD
CA353041793 rs1326653501	126	P>L		No	ClinGen gnomAD
CA2424701 rs776753541	127	A>S		No	ClinGen ExAC TOPMed gnomAD
CA2424702 rs759636482	127	A>V		No	ClinGen ExAC gnomAD
CA2424704 rs199663854	128	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1187547568 CA353041815	130	H>R		No	ClinGen gnomAD
rs763246169 CA2424705	131	V>L		No	ClinGen ExAC gnomAD
rs763246169 CA2424706	131	V>M		No	ClinGen ExAC gnomAD
CA74679269 rs199694207	132	V>M		No	ClinGen Ensembl
CA353041839 rs1411604828	134	A>V		No	ClinGen gnomAD
CA2424708 rs138150641	135	T>A		No	ClinGen ESP ExAC gnomAD
rs1452967456 CA353041845	136	F>I		No	ClinGen TOPMed
rs1267680230 CA353041856	137	P>R		No	ClinGen TOPMed
CA2424709 rs767989437	139	T>A		No	ClinGen ExAC gnomAD
rs767989437 CA353041867	139	T>P		No	ClinGen ExAC gnomAD
CA2424710 rs750951980	140	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1030749586 CA74679322	143	S>Y		No	ClinGen Ensembl
rs1288635204 CA353041896	144	I>F		No	ClinGen TOPMed
CA353041907 rs1348348106	145	W>*		No	ClinGen gnomAD
CA353041902 rs1236244898	145	W>R		No	ClinGen TOPMed
CA2424713 rs752292198	147	A>T		No	ClinGen ExAC gnomAD
rs777358599 CA2424715	148	T>N		No	ClinGen ExAC gnomAD
rs758059920 CA2424714	148	T>P		No	ClinGen ExAC gnomAD
rs371808148 CA2424716	149	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2424717 rs770650548	149	R>H		No	ClinGen ExAC TOPMed gnomAD
rs781232080 CA2424718	150	R>C		No	ClinGen ExAC gnomAD
rs745803321 CA2424719	150	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745803321 CA353041931	150	R>L		No	ClinGen ExAC TOPMed gnomAD
rs769934796 CA2424720	151	V>I		No	ClinGen ExAC gnomAD
rs912009143 CA74679380	152	H>R		No	ClinGen TOPMed gnomAD
CA353041944 rs1162784919	153	P>T		No	ClinGen TOPMed gnomAD
CA2424721 rs775697837	157	T>I		No	ClinGen ExAC TOPMed gnomAD
CA2424723 rs768891984	159	I>T		No	ClinGen ExAC gnomAD
CA353041986 rs1368605668	159	I>V		No	ClinGen gnomAD
CA2424749 rs761097253	162	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2424748 rs773556748	162	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2424750 rs766844593	164	L>V		No	ClinGen ExAC gnomAD
rs1281316019 CA353043138	165	C>R		No	ClinGen gnomAD
CA353043144 rs1173041240	165	C>W		No	ClinGen gnomAD
rs762481142 CA2424752	169	R>L		No	ClinGen ExAC gnomAD
rs762481142 CA353043166	169	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2424751 rs200150485	169	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs948580613 CA74689195	174	Q>E		No	ClinGen TOPMed
rs371777255 CA74689231	177	Q>H		No	ClinGen Ensembl
rs1006029295 CA74689221	177	Q>R		No	ClinGen Ensembl
CA2424755 rs756953605	180	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs371011006 CA2424758	186	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA2424757 COSM191105 rs148617571	186	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA2424760 rs749215563	187	Q>H		No	ClinGen ExAC gnomAD
CA2424759 rs779992812	187	Q>R		No	ClinGen ExAC gnomAD
rs755019035 CA2424761	190	F>V		No	ClinGen ExAC gnomAD
rs748478449 CA74689268	191	Y>C		No	ClinGen TOPMed gnomAD
CA2424762 rs778874112	191	Y>H		No	ClinGen ExAC gnomAD
rs778874112 CA353043335	191	Y>N		No	ClinGen ExAC gnomAD
rs1402945031 CA353043375	194	E>D		No	ClinGen TOPMed
TCGA novel	195	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2424763 rs748319268	195	M>V		No	ClinGen ExAC gnomAD
rs1024889737 CA74689290	197	E>D		No	ClinGen gnomAD
TCGA novel	202	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	203	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2424765 rs753054411	203	R>Q		No	ClinGen ExAC gnomAD
CA353043517 COSM3427730 rs1412349346	203	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs969044528 CA74689323	205	L>H		No	ClinGen Ensembl
CA353043571 rs1405482670	206	V>L		No	ClinGen gnomAD
TCGA novel	206	V>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1322297814 CA353043622	208	A>V		No	ClinGen gnomAD
rs747356480 CA2424767	209	I>M		No	ClinGen ExAC gnomAD
CA2424768 rs771311925	210	D>G		No	ClinGen ExAC gnomAD
CA2424772 rs773727438	216	T>R		No	ClinGen ExAC TOPMed gnomAD
CA74692403 rs773119646	218	A>T		No	ClinGen Ensembl
CA74692412 rs1021804956	220	T>A		No	ClinGen TOPMed gnomAD
rs1409327077 CA353045140	220	T>R		No	ClinGen TOPMed
rs1368728208 CA353045152	221	M>V		No	ClinGen TOPMed
CA353045213 rs1186344782	223	D>N		No	ClinGen gnomAD
rs370467260 CA74692423	224	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA2424790 rs370467260	224	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1366333185 CA353045233	224	T>P		No	ClinGen gnomAD
rs1471674584 CA353045269	225	S>T		No	ClinGen TOPMed
rs1168668889 CA353045312	228	S>R		No	ClinGen gnomAD
rs1429611161 CA353045371	231	V>G		No	ClinGen gnomAD
CA2424791 rs746307848	231	V>M		No	ClinGen ExAC gnomAD
rs374502236 CA2424792	232	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1396849792 CA353045403	235	S>G		No	ClinGen gnomAD
rs772933628 CA2424796	236	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2424795 rs771738706	236	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1298403063 CA353045488	239	S>L		No	ClinGen gnomAD
rs753571468 CA2424799	240	A>G		No	ClinGen ExAC gnomAD
rs760417570 CA2424797	240	A>P		No	ClinGen ExAC gnomAD
rs760417570 CA2424798	240	A>T		No	ClinGen ExAC gnomAD
rs752658008 CA2424802	245	P>A		No	ClinGen ExAC TOPMed gnomAD
CA74692504 rs375133563	245	P>L		No	ClinGen ESP TOPMed gnomAD
CA353045599 rs1280674115	247	A>V		No	ClinGen TOPMed
rs956868003 CA74692513	248	S>I		No	ClinGen Ensembl
rs1202744128 CA353045646	250	R>C		No	ClinGen gnomAD
rs369579500 CA2424804	250	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1559686636 CA353045680	252	W>*		No	ClinGen Ensembl
CA74692545 CA2424806 rs200027537	252	W>C		No	ClinGen ExAC gnomAD
CA353045707 rs1577542707	253	D>G		No	ClinGen Ensembl
CA74692558 rs200798093	255	G>C		No	ClinGen TOPMed gnomAD
COSM1424291 CA353045747 rs200798093	255	G>S	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs912780799 CA74692564	255	G>V		No	ClinGen Ensembl
rs1197570561 CA353045800	257	T>I		No	ClinGen gnomAD
rs1466906932 CA353045791	257	T>S		No	ClinGen gnomAD
rs756522578 CA2424809	258	R>C		No	ClinGen ExAC TOPMed gnomAD
rs756522578 CA74692585	258	R>G		No	ClinGen ExAC TOPMed gnomAD
rs780667450 CA2424810	258	R>H		No	ClinGen ExAC TOPMed gnomAD
rs756522578 CA353045804	258	R>S		No	ClinGen ExAC TOPMed gnomAD
rs369013696 CA353045831 CA2424814	259	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375977287 CA2424812	259	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2424815 rs770460422	260	E>K		No	ClinGen ExAC gnomAD
CA74692640 rs919904083	261	H>Q		No	ClinGen gnomAD
rs776397239 CA2424816	262	S>R		No	ClinGen ExAC gnomAD
rs555183400 CA2424818 CA353045909	264	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353045939 rs1253969226	267	G>S		No	ClinGen gnomAD
CA2424820 rs762861208	270	G>S		No	ClinGen ExAC TOPMed
CA353045997 rs1449106909	271	S>C		No	ClinGen TOPMed
CA2424821 rs764083278	272	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs764083278 CA353046005	272	S>Y		No	ClinGen ExAC gnomAD
rs367741404 CA2424822	273	F>S		No	ClinGen ESP ExAC gnomAD
rs757405334 CA2424823	275	E>D		No	ClinGen ExAC gnomAD
CA74692721 rs1015059122	275	E>G		No	ClinGen TOPMed
CA74692728 rs878921381	276	L>R		No	ClinGen Ensembl
CA2424824 rs767585708	277	D>V		No	ClinGen ExAC gnomAD
CA353046106 rs1270179741	280	G>S		No	ClinGen gnomAD
rs938455567 CA353046115	281	E>K		No	ClinGen TOPMed gnomAD
rs938455567 CA74692741	281	E>Q		No	ClinGen TOPMed gnomAD
rs780579663 CA2424827	282	G>E		No	ClinGen ExAC gnomAD
CA2424826 rs756366149	282	G>W		No	ClinGen ExAC gnomAD
rs1577543082 CA353046142	283	P>S		No	ClinGen Ensembl
rs749729109 CA2424828	285	G>V		No	ClinGen ExAC gnomAD
CA353046173 rs1057076234	286	E>D		No	ClinGen TOPMed gnomAD
CA2424830 rs779605686	288	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2424829 rs755538682	288	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1577543131 CA353046211	290	D>G		No	ClinGen Ensembl
CA353046225 rs746480852	291	P>H		No	ClinGen ExAC gnomAD
CA2424831 rs746480852	291	P>R		No	ClinGen ExAC gnomAD
VAR_061718 rs11553574 CA2424832	292	G>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1559686938 CA353046261	294	E>D		No	ClinGen Ensembl
CA353046254 rs1228752835	294	E>K		No	ClinGen gnomAD
CA2424834 rs776110618	295	P>R		No	ClinGen ExAC TOPMed gnomAD
rs769490279 CA2424836	297	G>A		No	ClinGen ExAC gnomAD
rs762773045 CA2424838	298	T>A		No	ClinGen ExAC gnomAD
rs774292309 CA2424841	299	T>N		No	ClinGen ExAC TOPMed gnomAD
CA2424840 rs774292309	299	T>S		No	ClinGen ExAC TOPMed gnomAD
CA74692830 rs904180792	300	K>R		No	ClinGen Ensembl
CA2424843 rs767638608	302	L>F		No	ClinGen ExAC gnomAD
rs61737032 CA353046352	302	L>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61737032 CA2424844	302	L>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1167009061 CA353046357	303	W>*		No	ClinGen gnomAD
rs760939105 CA2424845	304	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1457363076 CA353046384	305	P>S		No	ClinGen gnomAD
rs1372292240 CA353046400 COSM1133013	307	A>T	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA2424848 rs565332036	308	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754224540 CA2424847	308	P>S		No	ClinGen ExAC TOPMed gnomAD
rs775057028 CA2424850	311	G>S		No	ClinGen ExAC gnomAD
rs532507096 CA2424852	313	E>*		No	ClinGen 1000Genomes ExAC gnomAD

No associated diseases with Q9Y6I9

No regional properties for Q9Y6I9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9Y6I9

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type III membrane protein Cytoplasmic vesicle, autophagosome Cytoplasm, cytosol Nucleus Chromosome	Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif (PubMed:31006537) Also found in the cytosol, nucleus and chromatin (PubMed:32152270) In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks (PubMed:32152270)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
autophagosome membrane	The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
platelet alpha granule lumen	The volume enclosed by the membrane of the platelet alpha granule.
replication fork	The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

1 GO annotations of molecular function

Name	Definition
signaling receptor activity	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

2 GO annotations of biological process

Name	Definition
protein-DNA covalent cross-linking repair	The removal of covalent cross-link between DNA and a protein.
reticulophagy	The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSDLLLLGLI	GGLTLLLLLT	LLAFAGYSGL	LAGVEVSAGS	PPIRNVTVAY	KFHMGLYGET
70	80	90	100	110	120
GRLFTESCSI	SPKLRSIAVY	YDNPHMVPPD	KCRCAVGSIL	SEGEESPSPE	LIDLYQKFGF
130	140	150	160	170	180
KVFSFPAPSH	VVTATFPYTT	ILSIWLATRR	VHPALDTYIK	ERKLCAYPRL	EIYQEDQIHF
190	200	210	220	230	240
MCPLARQGDF	YVPEMKETEW	KWRGLVEAID	TQVDGTGADT	MSDTSSVSLE	VSPGSRETSA
250	260	270	280	290	300
ATLSPGASSR	GWDDGDTRSE	HSYSESGASG	SSFEELDLEG	EGPLGESRLD	PGTEPLGTTK
310
WLWEPTAPEK	GKE