AiPD: Autoinhibited Protein Database

Q9Y657

Gene name	SPIN1 (OCR, SPIN)
Protein name	Spindlin-1
Names	Ovarian cancer-related protein, Spindlin1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10927
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-73 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

20 structures for Q9Y657

Entry ID	Method	Resolution	Chain	Position	Source
2NS2	X-ray	220 A	A/B	26-262	PDB
4H75	X-ray	210 A	A	27-262	PDB
4MZF	X-ray	210 A	B	50-262	PDB
4MZG	X-ray	170 A	B/D	50-262	PDB
4MZH	X-ray	220 A	A	50-262	PDB
5JSG	X-ray	250 A	A/B	50-262	PDB
5JSJ	X-ray	235 A	A/B	50-262	PDB
5Y5W	X-ray	330 A	A/B/C/D	51-262	PDB
6I8B	X-ray	176 A	B/E	48-262	PDB
6I8L	X-ray	158 A	B	48-262	PDB
6I8Y	X-ray	152 A	A	48-262	PDB
6QPL	X-ray	160 A	B	48-262	PDB
7BQZ	X-ray	310 A	A/C/E/G	45-262	PDB
7BU9	X-ray	350 A	A/C/E/G	45-262	PDB
7CNA	X-ray	160 A	A/D	51-262	PDB
7E9M	X-ray	250 A	A/C	1-262	PDB
7EA1	X-ray	270 A	A/C	50-262	PDB
7OCB	X-ray	142 A	B	48-262	PDB
8GTX	X-ray	180 A	A	50-262	PDB
AF-Q9Y657-F1	Predicted				AlphaFoldDB

89 variants for Q9Y657

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1235992494 CA374018371	6	G>E		No	ClinGen TOPMed
CA5115500 rs765920402	6	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA374018385 rs1180691379	8	T>R		No	ClinGen gnomAD
rs1413683368 CA374018397	10	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs751098696 CA5115501	12	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA374018409 rs1183028320	12	R>W		No	ClinGen TOPMed
CA374018430 rs1358975011	15	A>V		No	ClinGen gnomAD
rs755530595 CA5115502	16	D>N		No	ClinGen ExAC gnomAD
rs867756808 CA196210537	18	G>C		No	ClinGen Ensembl
rs1375960799 CA374018473	19	H>R		No	ClinGen gnomAD
TCGA novel	21	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1276332216 CA374018491	22	V>L		No	ClinGen gnomAD
rs1278070223 CA374018521	26	M>I		No	ClinGen gnomAD
CA374018516 rs1325746125	26	M>V		No	ClinGen TOPMed
CA196213462 rs896227879	28	K>R		No	ClinGen gnomAD
CA374018544 rs1564037021	29	K>R		No	ClinGen Ensembl
rs1201150441 CA374018556	31	T>A		No	ClinGen gnomAD
rs1200033302 CA374018579	34	K>R		No	ClinGen gnomAD
rs1223429162 CA374018610	36	H>R		No	ClinGen TOPMed
TCGA novel	37	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5115550 rs750649140	39	S>N	Variant assessed as Somatic; 4.646e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5115551 rs758414581	40	V>L		No	ClinGen ExAC gnomAD
CA196215139 rs935713679	45	P>S		No	ClinGen TOPMed gnomAD
CA5115553 rs747157977	47	S>T		No	ClinGen ExAC gnomAD
rs1341368087 CA374018698	50	R>W	Variant assessed as Somatic; 9.281e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA374018704 rs1402037395	51	R>Q		No	ClinGen gnomAD
CA374018703 rs1337105433	51	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs951543305 CA196215140	54	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA5115555 rs777617889	56	C>S		No	ClinGen ExAC gnomAD
TCGA novel	64	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368325240 CA5115557	67	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs371335535 CA196215142	69	V>L		No	ClinGen ESP
CA374018858 rs1354754882	73	K>R		No	ClinGen TOPMed gnomAD
rs1209628001 CA374018876	76	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	87	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	90	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374019047 rs1156497850	101	E>Q		No	ClinGen TOPMed
rs1399697918 CA374019061	103	N>D		No	ClinGen TOPMed
TCGA novel	110	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196215143 rs982498128	110	A>V		No	ClinGen Ensembl
TCGA novel	115	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1261892597 CA374019153	116	D>G		No	ClinGen gnomAD
rs962670854 CA196215144	117	R>G		No	ClinGen TOPMed gnomAD
rs775111083 CA5115561	118	V>A		No	ClinGen ExAC gnomAD
CA5115582 rs547638675	119	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771830768 CA5115584	120	T>I		No	ClinGen ExAC gnomAD
rs11142308 CA196215835 COSM1463490	122	R>*	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA374017309 rs1379087842	123	I>V		No	ClinGen gnomAD
TCGA novel	125	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775305776 CA5115585	126	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1312444320 CA374017335	126	A>V		No	ClinGen gnomAD
rs1037746216 CA374017340	127	H>L		No	ClinGen TOPMed gnomAD
rs1037746216 CA196215836	127	H>R		No	ClinGen TOPMed gnomAD
rs1197705538 CA374017376	132	M>I		No	ClinGen TOPMed
CA5115589 rs762212475	140	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	144	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	144	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374017466 rs1434002749	145	D>N		No	ClinGen gnomAD
rs1026532152 CA196215838	147	S>C		No	ClinGen TOPMed gnomAD
CA374017483 rs1026532152	147	S>F		No	ClinGen TOPMed gnomAD
rs763354957 CA5115592	158	R>C		No	ClinGen ExAC gnomAD
CA374017561 rs1171407650	158	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	165	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201082729 CA196215839	173	D>G		No	ClinGen 1000Genomes
TCGA novel	174	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751757256 CA5115594	183	D>V		No	ClinGen ExAC gnomAD
CA374017800 rs1354814432	191	R>C		No	ClinGen TOPMed
rs371662192 CA5115598	194	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA374017840 rs1412300026	197	N>D		No	ClinGen TOPMed
rs1299616107 CA374017862	197	N>I		No	ClinGen gnomAD
rs1358146798 CA374017864	197	N>K		No	ClinGen gnomAD
CA374017867 rs1587820483	198	D>Y		No	ClinGen Ensembl
rs752700080 CA5115631	200	P>L		No	ClinGen ExAC gnomAD
CA374017886 rs1303477649	201	P>S		No	ClinGen TOPMed
rs1197846251 CA374017921	206	P>S		No	ClinGen gnomAD
CA374018003 rs1587820501	218	V>G		No	ClinGen Ensembl
TCGA novel	219	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_053690 CA196216775 rs34794905	221	A>P		No	ClinGen UniProt Ensembl dbSNP
CA5115636 rs779701197	221	A>V		No	ClinGen ExAC gnomAD
TCGA novel	224	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5115638 rs373183527	226	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5115640 rs747606376	227	K>E		No	ClinGen ExAC gnomAD
rs1431485810 CA374018080	229	T>I		No	ClinGen gnomAD
rs1180597011 CA374018084	230	G>D		No	ClinGen gnomAD
rs1385043784 CA374018088	231	M>V		No	ClinGen gnomAD
CA5115642 rs534075988	239	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA374018148 rs1037928980	239	K>M		No	ClinGen TOPMed
rs1037928980 CA196216776	239	K>R		No	ClinGen TOPMed
rs1587820523 CA374018153	240	P>S		No	ClinGen Ensembl

No associated diseases with Q9Y657

No regional properties for Q9Y657

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9Y657

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

1 GO annotations of molecular function

Name	Definition
methylated histone binding	Binding to a histone in which a residue has been modified by methylation.

8 GO annotations of biological process

Name	Definition
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
gamete generation	The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
meiotic cell cycle	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of Wnt signaling pathway	Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
rRNA transcription	The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MKTPFGKTPG	QRSRADAGHA	GVSANMMKKR	TSHKKHRSSV	GPSKPVSQPR	RNIVGCRIQH
70	80	90	100	110	120
GWKEGNGPVT	QWKGTVLDQV	PVNPSLYLIK	YDGFDCVYGL	ELNKDERVSA	LEVLPDRVAT
130	140	150	160	170	180
SRISDAHLAD	TMIGKAVEHM	FETEDGSKDE	WRGMVLARAP	VMNTWFYITY	EKDPVLYMYQ
190	200	210	220	230	240
LLDDYKEGDL	RIMPDSNDSP	PAEREPGEVV	DSLVGKQVEY	AKEDGSKRTG	MVIHQVEAKP
250	260
SVYFIKFDDD	FHIYVYDLVK	TS