AiPD: Autoinhibited Protein Database

Q9Y570

Gene name	PPME1 (PME1, PP2593, PRO0750)
Protein name	Protein phosphatase methylesterase 1
Names	PME-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51400
EC number	3.1.1.89: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-61 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9Y570

Entry ID	Method	Resolution	Chain	Position	Source
3C5V	X-ray	200 A	A	39-386	PDB
3C5W	X-ray	280 A			PDB
7SOY	EM	340 A	P	1-386	PDB
AF-Q9Y570-F1	Predicted				AlphaFoldDB

253 variants for Q9Y570

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1409847400 CA381828942	3	A>T		No	ClinGen gnomAD
rs1282062289 CA381828950	4	L>F		No	ClinGen gnomAD
rs764593205 CA6183385	5	E>K		No	ClinGen ExAC gnomAD
rs1234947884 CA381828975	7	S>R		No	ClinGen gnomAD
rs1256244844 CA381828986	9	H>D		No	ClinGen TOPMed gnomAD
CA6183386 rs752024417	9	H>L		No	ClinGen ExAC gnomAD
CA381828988 rs1256244844	9	H>N		No	ClinGen TOPMed gnomAD
CA381828989 rs752024417	9	H>P		No	ClinGen ExAC gnomAD
CA224528103 rs757643501	9	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA381829018 rs1483330250	11	G>A		No	ClinGen gnomAD
CA381829020 rs1483330250	11	G>V		No	ClinGen gnomAD
rs74755631 CA6183389	12	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381829031 rs755713025	12	R>H		No	ClinGen ExAC gnomAD
rs755713025 CA6183390	12	R>L		No	ClinGen ExAC gnomAD
CA6183392 rs763179389	15	S>C		No	ClinGen ExAC gnomAD
CA6183393 rs768214869	16	R>H		No	ClinGen ExAC gnomAD
CA6183394 rs368008667	17	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs748048802 CA6183395	18	P>L		No	ClinGen ExAC gnomAD
CA224528118 rs748048802	18	P>R		No	ClinGen ExAC gnomAD
rs200494233 CA6183398	20	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765391880 CA6183399	21	G>S		No	ClinGen ExAC gnomAD
CA381829243 rs1225788323	22	S>N		No	ClinGen gnomAD
CA381829272 rs1591002930	23	G>E		No	ClinGen Ensembl
CA6183400 rs775719270	23	G>W		No	ClinGen ExAC
CA6183401 rs762979115	24	G>A		No	ClinGen ExAC gnomAD
CA224528145 rs926088219	25	S>T		No	ClinGen Ensembl
CA381829353 rs1411988209	28	G>A		No	ClinGen TOPMed
TCGA novel	28	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381829357 rs1221636206	29	A>T		No	ClinGen gnomAD
rs764113232 CA6183402	29	A>V		No	ClinGen ExAC gnomAD
rs1389950393 CA381829383	30	K>N		No	ClinGen Ensembl
rs752106296 CA6183403	30	K>R		No	ClinGen ExAC TOPMed gnomAD
rs752106296 CA381829372	30	K>T		No	ClinGen ExAC TOPMed gnomAD
CA381829401 rs1261236408	31	M>I		No	ClinGen gnomAD
rs1210538113 CA381829396	31	M>T		No	ClinGen gnomAD
CA6183404 rs757727370	32	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1258751054 CA381829416	33	M>V		No	ClinGen TOPMed
CA224528161 rs1055937547	34	G>C		No	ClinGen Ensembl
rs1055937547 CA224528158	34	G>R		No	ClinGen Ensembl
CA381822384 rs1327084832	35	P>S		No	ClinGen gnomAD
CA381822407 rs1254581437	36	G>E		No	ClinGen TOPMed
CA224520295 rs749294771	37	R>G		No	ClinGen Ensembl
rs1230341463 CA381822423	37	R>K		No	ClinGen gnomAD
CA6183433 rs766714868	39	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs199766005 CA6183432	39	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1208337187 CA381822511	40	D>H		No	ClinGen gnomAD
rs754675778 CA6183435	42	S>F		No	ClinGen ExAC TOPMed gnomAD
CA381822569 rs148853537	42	S>P		No	ClinGen 1000Genomes ExAC gnomAD
CA6183434 rs148853537	42	S>T		No	ClinGen 1000Genomes ExAC gnomAD
rs765150817 CA6183436	43	P>L		No	ClinGen ExAC gnomAD
CA381822607 rs1216000807	44	V>L		No	ClinGen TOPMed
rs545915245 CA6183437	45	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA6183438 rs201971289	48	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1160767433 CA381822850	51	E>G		No	ClinGen gnomAD
CA381822863 rs1591034002	52	S>A		No	ClinGen Ensembl
rs1017799427 CA224520313	53	M>V		No	ClinGen gnomAD
rs576331375 CA224520314	54	E>*		No	ClinGen 1000Genomes
CA6183441 rs746920933	55	D>E		No	ClinGen ExAC gnomAD
rs1413523426 CA381822962	55	D>H		No	ClinGen gnomAD
CA6183439 rs777607423	55	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1448489714 CA381823003	56	V>I		No	ClinGen gnomAD
CA224520345 rs928862604	57	E>D		No	ClinGen TOPMed gnomAD
CA381823067 rs1348545968	58	V>I		No	ClinGen TOPMed
rs781012190 CA6183442	63	G>V		No	ClinGen ExAC gnomAD
CA381823288 rs201122913	65	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381823278 rs1345039884	65	D>H		No	ClinGen gnomAD
rs201122913 CA6183443	65	D>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	65	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381823643 rs1388079868	66	T>A		No	ClinGen TOPMed gnomAD
rs1565382572 CA381823713	68	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA6183467 rs372101043	68	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1389957931 CA381823764	69	V>A		No	ClinGen gnomAD
rs1292554959 CA381823781	70	Y>C		No	ClinGen TOPMed
CA6183468 rs375196294	70	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6183469 rs369439716	72	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA381823868 rs1434640663	74	S>P		No	ClinGen gnomAD
rs771482802 CA6183470	79	L>V		No	ClinGen ExAC gnomAD
rs777214061 CA6183471	83	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA381824041 rs1229647312	85	G>R		No	ClinGen gnomAD
TCGA novel	91	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6183476 COSM195922 rs79972734	96	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA224520718 rs79972734	96	T>R		No	ClinGen ExAC gnomAD
CA6183486 rs369415883	97	A>T		No	ClinGen ESP ExAC gnomAD
CA381829459 rs1330742033	98	A>E		No	ClinGen gnomAD
rs1330742033 CA381829462	98	A>V		No	ClinGen gnomAD
rs757906428 CA6183487	101	S>G		No	ClinGen ExAC TOPMed gnomAD
CA6183488 rs372623470	101	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA224527455 rs372623470	101	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	104	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1237989877 CA381829534	104	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs746358367 CA6183490	106	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6183491 rs770326611	106	R>K		No	ClinGen ExAC gnomAD
CA6183492 rs775996554	107	I>T		No	ClinGen ExAC
rs1050244648 CA224527471	114	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA224527472 rs780960664	114	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381830116 rs1170957871	117	E>A		No	ClinGen gnomAD
rs1462006827 CA381830172	120	V>F		No	ClinGen gnomAD
rs866562265 CA224528138	121	K>N		No	ClinGen Ensembl
rs757409598 CA6183505	121	K>R		No	ClinGen ExAC gnomAD
CA381830222 rs1389598971	124	E>K		No	ClinGen TOPMed
CA224528142 rs868676041	130	T>K		No	ClinGen Ensembl
rs780646907 CA6183509	131	M>K		No	ClinGen ExAC gnomAD
CA381830315 rs1364112415	131	M>V		No	ClinGen gnomAD
CA6183528 rs368206869	135	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1410632386 CA381831190	137	N>S		No	ClinGen gnomAD
rs1455309198 CA381831195	138	V>M		No	ClinGen gnomAD
CA381831202 rs1160996700	139	V>L		No	ClinGen gnomAD
CA381831217 rs1490717854	141	A>T		No	ClinGen gnomAD
CA381831225 rs1300967498	142	M>I		No	ClinGen gnomAD
CA224530227 rs907097327	142	M>L		No	ClinGen TOPMed gnomAD
CA6183529 rs370581566	142	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA381831222 rs907097327	142	M>V		No	ClinGen TOPMed gnomAD
rs1265994610 CA381831255	146	L>H		No	ClinGen TOPMed gnomAD
CA381831254 rs1265994610	146	L>P		No	ClinGen TOPMed gnomAD
CA381831261 rs1381279041	147	P>L		No	ClinGen gnomAD
CA224530235 rs1015218847	148	P>L		No	ClinGen TOPMed
CA6183532 rs771698562	150	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs772786657 CA6183533	151	M>T		No	ClinGen ExAC gnomAD
rs746553704 CA6183534	157	M>V		No	ClinGen ExAC gnomAD
rs962687227 CA224530262	158	G>C		No	ClinGen TOPMed
rs1285226424 CA381831331	158	G>D		No	ClinGen gnomAD
rs1160706559 CA381831339	159	G>V		No	ClinGen gnomAD
rs973798171 CA224530266	161	I>M		No	ClinGen TOPMed
TCGA novel	163	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6183535 rs770381896	165	T>A		No	ClinGen ExAC gnomAD
CA224530276 rs926614381	165	T>R		No	ClinGen Ensembl
rs776680850 CA6183536	167	S>L		No	ClinGen ExAC gnomAD
CA381831391 rs1234404169	168	S>C		No	ClinGen TOPMed
rs1486269578 CA381831387	168	S>T		No	ClinGen gnomAD
CA381831390 rs1234404169	168	S>Y		No	ClinGen TOPMed
rs1205153772 CA381831393	169	N>H		No	ClinGen gnomAD
rs938028891 CA224530295	169	N>S		No	ClinGen TOPMed gnomAD
CA381831427 rs1371457735	174	L>F		No	ClinGen TOPMed
CA381831437 rs1157162865	175	L>F		No	ClinGen gnomAD
CA224530316 rs561893654	178	C>S		No	ClinGen 1000Genomes
rs1394233458 CA381831460	179	M>K		No	ClinGen TOPMed
rs200677438 CA6183540	179	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA381831470 rs1174195630	180	I>M		No	ClinGen TOPMed
rs1432333635 CA381831465	180	I>V		No	ClinGen gnomAD
TCGA novel	181	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	182	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	182	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6183541 rs767852974	184	E>D		No	ClinGen ExAC gnomAD
TCGA novel	190	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381832025 rs1454553767	192	N>S		No	ClinGen gnomAD
CA381832030 rs1167842127	193	S>C		No	ClinGen gnomAD
CA381832047 rs1388275268	195	Q>E		No	ClinGen gnomAD
rs1411641943 CA381832068	197	F>C		No	ClinGen gnomAD
CA224530599 rs866029443	199	R>L		No	ClinGen gnomAD
CA381832081 rs866029443	199	R>P		No	ClinGen gnomAD
rs1329591884 CA381832079	199	R>W		No	ClinGen TOPMed gnomAD
rs746643845 CA6183554	200	G>C		No	ClinGen ExAC TOPMed gnomAD
rs746643845 CA6183553	200	G>S		No	ClinGen ExAC TOPMed gnomAD
CA381832088 rs1372096928	201	R>C		No	ClinGen TOPMed gnomAD
CA381832089 rs1228165080	201	R>H		No	ClinGen TOPMed gnomAD
CA224530633 rs1046459001	203	K>T		No	ClinGen TOPMed
CA6183556 rs776004013	204	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1206017827 CA381832109	204	T>I		No	ClinGen TOPMed
rs769636964 CA6183558	205	F>L		No	ClinGen ExAC gnomAD
CA381832124 rs1565391841	206	K>N		No	ClinGen Ensembl
rs1342747324 CA381832117	206	K>Q		No	ClinGen TOPMed
rs1320607429 CA381832121	206	K>R		No	ClinGen TOPMed gnomAD
CA6183559 rs775427211	208	L>V		No	ClinGen ExAC gnomAD
CA6183560 rs183405413	212	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA224532890 rs989090156	218	S>T		No	ClinGen Ensembl
rs1439580047 CA381832752	219	G>S		No	ClinGen gnomAD
rs1456909589 CA381832762	220	Q>*		No	ClinGen gnomAD
rs1387513445 CA381832788	222	R>*		No	ClinGen TOPMed gnomAD
CA381832790 rs1387513445	222	R>G		No	ClinGen TOPMed gnomAD
rs756849807 CA6183576	224	L>V		No	ClinGen ExAC TOPMed gnomAD
rs549878530 CA6183577	228	R>C		No	ClinGen ExAC TOPMed gnomAD
CA381832854 rs1440089111	228	R>H		No	ClinGen TOPMed
CA381832890 rs1294594893	231	M>I		No	ClinGen gnomAD
CA6183578 rs572746963	231	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA224532895 rs1014227253	235	V>I		No	ClinGen TOPMed
rs190849735 CA6183600	238	C>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755625023 CA6183601	241	I>V		No	ClinGen ExAC gnomAD
rs749302477 CA6183603	246	G>C		No	ClinGen ExAC gnomAD
CA6183604 rs768700784	249	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1311813633 CA381833671	250	I>T		No	ClinGen gnomAD
rs1203086355 CA381833676	251	V>L		No	ClinGen gnomAD
CA6183605 rs778936164	253	G>R		No	ClinGen ExAC TOPMed gnomAD
rs555905786 CA6183606	254	I>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381833699 rs555905786	254	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381833718 rs1209742146	257	E>*		No	ClinGen TOPMed
TCGA novel	257	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6183608 rs771852576	258	E>K		No	ClinGen ExAC gnomAD
rs776767719 CA6183609	260	E>D		No	ClinGen ExAC gnomAD
rs1440762650 CA381833751	261	D>V		No	ClinGen TOPMed
rs199836683 CA6183611	268	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs375020267 CA6183610	268	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6183612 rs775537086	270	K>R		No	ClinGen ExAC gnomAD
rs762965559 CA6183613	271	R>K		No	ClinGen ExAC gnomAD
CA224534573 rs970804085	272	K>R		No	ClinGen TOPMed
TCGA novel	273	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA224534578 rs750675406	274	E>G		No	ClinGen Ensembl
CA381833839 rs1322490220	274	E>K		No	ClinGen gnomAD
CA381833855 rs1368465978	276	D>H		No	ClinGen gnomAD
rs1303941572 CA381833863	277	M>V		No	ClinGen gnomAD
CA381834866 rs1267876184	279	T>I		No	ClinGen gnomAD
CA224538537 rs929778503	280	K>N		No	ClinGen TOPMed gnomAD
CA6183631 rs768668961	280	K>R		No	ClinGen ExAC gnomAD
rs774766774 CA381834889	281	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1265774042 CA381834903	282	D>E		No	ClinGen TOPMed
rs867519237 CA224538551	283	H>N		No	ClinGen Ensembl
rs1423794976 CA381834911	283	H>R		No	ClinGen gnomAD
CA381834926 rs1186185230	284	P>Q		No	ClinGen gnomAD
CA381834923 rs1186185230	284	P>R		No	ClinGen gnomAD
CA6183634 rs767833918	286	T>A		No	ClinGen ExAC gnomAD
rs773611499 CA6183635	286	T>I		No	ClinGen ExAC TOPMed gnomAD
CA224538571 rs866998019	292	A>T		No	ClinGen Ensembl
rs1387546110 CA381835058	296	K>E		No	ClinGen gnomAD
rs367984063 CA6183637 COSM195924	300	G>S	Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA381835133 rs1364644182	303	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA224538575 rs1048253176	303	R>Q		No	ClinGen gnomAD
CA224538581 rs972443191	304	G>A		No	ClinGen TOPMed gnomAD
CA381835139 rs972443191	304	G>D		No	ClinGen TOPMed gnomAD
CA224538597 rs888354839	307	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	308	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs11537843 CA224538600	310	L>V		No	ClinGen Ensembl
rs1287970554 CA381835206	314	I>T		No	ClinGen gnomAD
rs1315462537 CA381835214	315	P>L		No	ClinGen gnomAD
rs888102620 CA224539045	323	V>I		No	ClinGen TOPMed
CA224540391 rs904700564	338	K>R		No	ClinGen TOPMed
TCGA novel	339	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1565398007 CA381836006	340	Q>E		No	ClinGen Ensembl
rs1156479098 CA381836019	341	M>I		No	ClinGen TOPMed
CA381836017 rs1379410547	341	M>T		No	ClinGen TOPMed
rs754128911 CA6183667	342	Q>E		No	ClinGen ExAC gnomAD
CA381836026 rs1425964111	342	Q>R		No	ClinGen TOPMed gnomAD
CA381836043 rs1191482186	345	P>H		No	ClinGen TOPMed gnomAD
CA381836042 rs1467828212	345	P>S		No	ClinGen TOPMed gnomAD
rs1565398027 CA381836052	346	Q>H		No	ClinGen Ensembl
TCGA novel	348	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1254731515 CA381836068	349	H>Y		No	ClinGen gnomAD
CA6183669 rs778947333	351	V>I		No	ClinGen ExAC gnomAD
rs763885308 CA224540400	355	A>D		No	ClinGen ExAC gnomAD
CA6183670 rs763885308	355	A>V		No	ClinGen ExAC gnomAD
rs1255448294 CA381836242	362	A>G		No	ClinGen TOPMed
rs758544967 CA6183688	364	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1167392781 CA381836333	368	I>T		No	ClinGen TOPMed gnomAD
rs777709827 CA6183689 COSM3769447	369	R>W	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6183690 rs747576476	372	F>I		No	ClinGen ExAC gnomAD
rs1347442378 CA381836434	374	E>G		No	ClinGen TOPMed gnomAD
CA381836446 rs1316697283	375	P>A		No	ClinGen TOPMed
CA6183692 rs373808614	376	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3375948 CA6183694 rs770001714	377	G>S	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs775253017 CA6183695	379	F>L		No	ClinGen ExAC gnomAD
rs762486131 CA6183696	380	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA381836577 rs1335180617	381	C>R		No	ClinGen gnomAD
CA6183746 rs200531037	382	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA381837415 rs1355250692	383	F>L		No	ClinGen TOPMed
CA224541699 rs751225524	384	P>S		No	ClinGen TOPMed gnomAD

No associated diseases with Q9Y570

1 regional properties for Q9Y570

Type	Name	Position	InterPro Accession
domain	Alpha/beta hydrolase fold-1	79 - 362	IPR000073

Functions

		Description
EC Number	3.1.1.89	Carboxylic ester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

9 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
lncRNA binding	Binding to a long noncoding RNA (lncRNA).
protein C-terminal methylesterase activity	Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein methylesterase activity	Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.
protein phosphatase 2A binding	Binding to protein phosphatase 2A.
protein phosphatase binding	Binding to a protein phosphatase.
protein phosphatase inhibitor activity	Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins.
protein phosphatase regulator activity	Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

3 GO annotations of biological process

Name	Definition
G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
protein demethylation	The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSALEKSMHL	GRLPSRPPLP	GSGGSQSGAK	MRMGPGRKRD	FSPVPWSQYF	ESMEDVEVEN
70	80	90	100	110	120
ETGKDTFRVY	KSGSEGPVLL	LLHGGGHSAL	SWAVFTAAII	SRVQCRIVAL	DLRSHGETKV
130	140	150	160	170	180
KNPEDLSAET	MAKDVGNVVE	AMYGDLPPPI	MLIGHSMGGA	IAVHTASSNL	VPSLLGLCMI
190	200	210	220	230	240
DVVEGTAMDA	LNSMQNFLRG	RPKTFKSLEN	AIEWSVKSGQ	IRNLESARVS	MVGQVKQCEG
250	260	270	280	290	300
ITSPEGSKSI	VEGIIEEEEE	DEEGSESISK	RKKEDDMETK	KDHPYTWRIE	LAKTEKYWDG
310	320	330	340	350	360
WFRGLSNLFL	SCPIPKLLLL	AGVDRLDKDL	TIGQMQGKFQ	MQVLPQCGHA	VHEDAPDKVA
370	380
EAVATFLIRH	RFAEPIGGFQ	CVFPGC